Chemokine CCL18

A CC-type chemokine highly expressed in the lungs, lymph nodes, placenta, and bone marrow; it is also expressed by DENDRITIC CELLS in the GERMINAL CENTER, and peripheral blood MACROPHAGES. It functions as a chemotactic factor that specifically attracts LYMPHOCYTES, especially B-Cells, into lymph node follicles, and naive T-cells towards dendritic cells and activated T-cells. It does not attract MONOCYTES or GRANULOCYTES.

Also Known As:

Networked: 40 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tsicopoulos, Anne: 2 articles (01/2018 - 07/2003)
2.	Song, Erwei: 2 articles (01/2017 - 01/2014)
3.	Su, Shicheng: 2 articles (01/2017 - 01/2014)
4.	Hallman, Mikko: 2 articles (01/2015 - 09/2010)
5.	Kallankari, Hanna: 2 articles (01/2015 - 09/2010)
6.	Kaukola, Tuula: 2 articles (01/2015 - 09/2010)
7.	Kingsmore, Stephen F: 2 articles (01/2015 - 09/2010)
8.	Ojaniemi, Marja: 2 articles (01/2015 - 09/2010)
9.	Mantovani, Alberto: 2 articles (04/2011 - 07/2002)
10.	Aerts, Johannes M F G: 2 articles (10/2006 - 01/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "In the present study, we focus on the role of the chemokine CCL18 and its receptors in the GBM tumor. " 02/27/2023 - "TME deconvolution and cell interaction analyses allow us to identify the chemokine CCL18 secreted by tumor associated macrophages could promote tumor cell proliferation via JAK2/STAT3 signaling pathway and lead to poor prognosis of ESCC. " 01/01/2018 - "The chemokine CCL18 is constitutively expressed in human lung and serum, and is further elevated during pathologic conditions such as allergy, fibrosis and cancer, suggesting that it may participate in both homeostatic and inflammatory processes. " 04/12/2011 - "In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and correlates with metastasis in human breast cancer. " 11/01/2016 - "These findings suggest that the CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. "
2.	Neoplasm Metastasis (Metastasis) 12/01/2018 - "Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis, but the underlying mechanisms remain less clear. " 04/12/2011 - "In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and correlates with metastasis in human breast cancer. " 11/01/2016 - "These findings suggest that the CCL18 chemokine has an important role in chemokine-mediated tumor metastasis, and may serve as a potential predictor for poor survival outcomes for ovarian cancer. " 01/01/2014 - "We recently identified a vicious cycle between granulocyte macrophage colony stimulating factor (GM-CSF) arising from breast cancer cells that have undergone epithelial-mesenchymal transition (EMT) and the tumor-associated macrophage (TAM)-derived chemokine CCL18, a signaling loop that promotes tumor metastasis. "
3.	Breast Neoplasms (Breast Cancer) 12/01/2018 - "Our recent study showed that chemokine CCL18 secreted from tumor-associated macrophages regulates breast tumor metastasis, but the underlying mechanisms remain less clear. " 04/12/2011 - "In this issue of Cancer Cell, Chen et al. report that the chemokine CCL18, produced by tumor-associated macrophages, promotes malignant behavior and correlates with metastasis in human breast cancer. " 01/01/2014 - "We recently identified a vicious cycle between granulocyte macrophage colony stimulating factor (GM-CSF) arising from breast cancer cells that have undergone epithelial-mesenchymal transition (EMT) and the tumor-associated macrophage (TAM)-derived chemokine CCL18, a signaling loop that promotes tumor metastasis. "
4.	Peritonitis 01/01/2018 - "In conclusion, our study suggests that the chemokine CCL18 can be a mediator of peritoneal membrane failure associated with peritonitis episodes as well as providing a new potential therapeutic target." 01/01/2018 - "Prominent Levels of the Profibrotic Chemokine CCL18 during Peritonitis: In Vitro Downregulation by Vitamin D Receptor Agonists."
5.	Parapsoriasis 09/01/2011 - "In this study, we show by PCR analysis and immunofluorescence staining that the chemokine CCL18 is present in skin biopsy specimens of patients with MF and its precursor form parapsoriasis en plaque but not in healthy tissue. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Chemokines
3.	Proteins (Proteins, Gene)
4.	Ligands
5.	Interleukins
6.	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)
7.	CC Chemokines
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	Interleukin-10 (Interleukin 10)
10.	Interleukin-8 (Interleukin 8)