Connexin 30

A gap junction beta subunit that forms heteromeric hemichannels when paired with alpha subunits such as connexin-40 or CONNEXIN 43. Mutations in the connexin 30 gene (GJ6B) are associated with CLOUSTON'S SYNDROME and some hereditary forms of deafness.

Also Known As:

Networked: 70 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Schrijver, Iris: 4 articles (12/2014 - 06/2009)
2.	Crispino, Giulia: 3 articles (11/2017 - 12/2008)
3.	Mammano, Fabio: 3 articles (11/2017 - 12/2008)
4.	Rodriguez-Paris, Juan: 3 articles (12/2014 - 11/2009)
5.	Wonkam, Ambroise: 2 articles (10/2019 - 01/2019)
6.	Fujita, Atsushi: 2 articles (08/2018 - 01/2018)
7.	Kira, Jun-Ichi: 2 articles (08/2018 - 01/2018)
8.	Yamaguchi, Hiroo: 2 articles (08/2018 - 01/2018)
9.	Yamasaki, Ryo: 2 articles (08/2018 - 01/2018)
10.	Oghalai, John S: 2 articles (09/2016 - 12/2014)

Related Diseases

1.	Hearing Loss (Hearing Impairment) 01/01/2019 - "The connexin 30 A88V mutant reduces cochlear gap junction expression and confers long-term protection against hearing loss." 01/01/2022 - "Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss." 01/01/2020 - "Mutations in connexin 30 (Cx30) are known to cause severe congenital hearing impairment; however, the mechanism by which Cx30 mediates homeostasis of endocochlear gap junctions is unclear. " 12/20/2014 - "GJB6, OTOA, and STRC, encoding connexin 30, otoancorin, and stereocilin, respectively), supporting CNV contributions to hearing loss phenotypes. " 06/01/2013 - "Mouse otocyst transuterine gene transfer restores hearing in mice with connexin 30 deletion-associated hearing loss."
2.	Disease Progression 12/16/2022 - "Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation."
3.	Inflammation (Inflammations) 12/16/2022 - "Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation."
4.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 12/16/2022 - "Connexin 30 Deficiency Ameliorates Disease Progression at the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by Suppressing Glial Inflammation."
5.	Deafness (Deaf Mutism) 11/15/2002 - "Functional studies of human skin disease- and deafness-associated connexin 30 mutations." 12/15/2010 - "The human deafness-associated connexin 30 T5M mutation causes mild hearing loss and reduces biochemical coupling among cochlear non-sensory cells in knock-in mice." 11/01/2017 - "Using mutant mouse models for the most common form of congenital deafness in humans, which are knock-outs for the gap-junction channels connexin 26 and connexin 30 genes, we show that defects in nonsensory cells prevented the functional maturation of inner hair cells. " 01/01/2012 - "Connexin 26 and connexin 30 mutations are the most prevalent causes of deafness. " 06/10/2009 - "Mutations in the genes that encode Connexin 26 (GJB2) and Connexin 30 (GJB6) are the most common known cause of hereditary nonsyndromic sensorineural deafness. "

Related Drugs and Biologics

1.	Connexin 26
2.	Proteins (Proteins, Gene)
3.	Connexin 43 (Connexin43)
4.	Membrane Proteins (Integral Membrane Proteins)
5.	Gadolinium
6.	Connexins
7.	Epithelial Sodium Channels
8.	Metalloproteases (Metalloproteinases)
9.	Somatomedin Receptors (Somatomedin Receptor)
10.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)

Related Therapies and Procedures

1.	Cochlear Implantation
2.	Radiotherapy
3.	Cochlear Implants (Cochlear Implant)