Janus Kinase Inhibitors

Agents that inhibit JANUS KINASES.

Also Known As:

JAK Inhibitors; Inhibitor, JAK; Inhibitor, Janus Kinase; Inhibitors, JAK; Inhibitors, Janus Kinase; Kinase Inhibitor, Janus; Kinase Inhibitors, Janus; JAK Inhibitor; Janus Kinase Inhibitor

Networked: 2371 relevant articles (327 outcomes, 397 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Enzyme Inhibitors: 1659
      - Protein Kinase Inhibitors: 571
        Janus Kinase Inhibitors: 2371

Experts

1.	Verstovsek, Srdan: 44 articles (07/2022 - 01/2009)
2.	Tanaka, Yoshiya: 39 articles (07/2022 - 01/2012)
3.	Su, Chinyu: 28 articles (07/2022 - 08/2012)
4.	Mesa, Ruben A: 24 articles (01/2022 - 01/2013)
5.	Krishnaswami, Sriram: 24 articles (12/2020 - 04/2009)
6.	Gruben, David: 22 articles (01/2022 - 04/2009)
7.	Zwillich, Samuel H: 20 articles (01/2020 - 07/2009)
8.	Harrison, Claire N: 18 articles (07/2022 - 01/2013)
9.	Lawendy, Nervin: 18 articles (06/2022 - 04/2009)
10.	Curtis, Jeffrey R: 18 articles (02/2022 - 05/2014)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2018 - "Thus, JAK inhibitors can be potentially clinically effective not only in rheumatoid arthritis but other immune-related diseases." 11/01/2023 - "Real-world comparative study of the efficacy of Janus kinase inhibitors in patients with rheumatoid arthritis: the ANSWER cohort study." 05/01/2023 - "Efficacy of Janus kinase inhibitors in rheumatoid arthritis." 05/01/2022 - "In this longitudinal study, we assessed the role of musculoskeletal ultrasound (US) in predicting the efficacy of JAK inhibitors (JAKi) in rheumatoid arthritis (RA) patients. " 03/01/2022 - "Over the past two decades, the clinical outcomes of rheumatoid arthritis have improved substantially with the development of biological agents and Janus kinase inhibitors. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 11/01/2022 - "Our study confirmed that JAK inhibitors had promising treatment efficacy for moderate-to-severe plaque psoriasis. " 09/27/2022 - "The objective of this study was to determine the efficacy of several JAK inhibitors in treating psoriasis and PsA and examine safety concerns. " 01/01/2022 - "Our search was expanded from clinical trials to further investigate the pathophysiology, standard of care, and safety and efficacy of JAK inhibitors in psoriasis. " 09/22/2021 - "Oral JAK inhibitors show promise for efficacy and safety in the treatment of psoriasis. " 05/01/2021 - "Besides, psoriasis-related dermal lesions could also be improved by JAK inhibitors. "
3.	Atopic Dermatitis (Atopic Eczema) 01/01/2020 - "JAK inhibitors appear to be effective in treating atopic dermatitis. " 07/01/2021 - "Janus kinase inhibitors for atopic dermatitis: a promising treatment modality." 01/01/2023 - "The treatment of atopic dermatitis (AD) patients with insufficient response or intolerance to topical medication remains clinical challenges, and there is a paucity of head-to-head trials comparing the efficacy of novel biological agents such as JAK inhibitor and antibody. " 08/24/2022 - "However, further studies are needed to determine the long-term efficacy of Janus kinase inhibitors in adults with moderate-to-severe atopic dermatitis." 01/01/2021 - "The efficacy of Janus kinase inhibitors in patients with atopic dermatitis: A systematic review and network meta-analysis."
4.	Alopecia Areata 01/01/2020 - "Clinical trials with topical and systemic JAK inhibitors for alopecia areata are ongoing, and hopefully will provide us with better understanding of the safety and efficacy of these medications. " 07/15/2017 - "Despite the promising potential in alopecia areata treatment, research evaluating the efficacy of different Janus kinase inhibitors and possible prognostic factors related with a more favorable response are warranted." 01/01/2023 - "JAK inhibitors are effective in alopecia areata, although associated with an increased risk." 01/01/2021 - "However, the question remains, "Are JAK inhibitors effective and safe in the management of Alopecia Areata?". " 04/04/2023 - "Recently, the impressive efficacy of JAK-inhibitors (JAK-I) in alopecia areata (AA) has been described in several studies; however, to date, there is limited information on the safety of JAK-I in AA patients. "
5.	Ulcerative Colitis 08/01/2020 - "Efficacy of JAK inhibitors in Ulcerative Colitis." 01/27/2020 - "Oral Janus kinase inhibitors for maintenance of remission in ulcerative colitis." 11/16/2023 - "In this study, we integrated machine learning (ML), structure-tissue selectivity-activity-relationship (STAR), - and wet lab synthesis/testing to design a gastrointestinal (GI) locally activating JAK inhibitor for ulcerative colitis treatment. " 01/01/2023 - "Tofactinib is a JAK inhibitor approved for ulcerative colitis in humans. " 01/01/2023 - "Risk minimization of JAK inhibitors in ulcerative colitis following regulatory guidance."

Related Drugs and Biologics

1.	tofacitinib
2.	Janus Kinases
3.	ruxolitinib
4.	baricitinib
5.	upadacitinib
6.	Cytokines
7.	Janus Kinase Inhibitors
8.	peficitinib
9.	Antirheumatic Agents (DMARD)
10.	Tumor Necrosis Factor Inhibitors

Related Therapies and Procedures

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3.	Aftercare (After-Treatment)
4.	Phototherapy (Light Therapy)
5.	Precision Medicine