Metallocenes

03/01/2012 - "Novel potent metallocenes against liver stage malaria."
08/01/2005 - "[Metallocenes and malaria: a new therapeutic approach]."
01/01/2017 - "This area has attracted many researchers as well as the pharmaceutical industry due to the promising results of some metallocenes, in particular ferrocene compounds, in breast cancer and malaria."

02/01/2015 - "Cytokinesis-block micronucleus assay (CBMN) was performed on these ferrocenes and it was determined they induce micronucleus formation on binucleated cells and moderate genotoxic effects on the MCF-7 breast cancer cell line. "
08/01/2009 - "The growth inhibition of the antitumour metallocenes (eta(5)-C5H5)2TiCl2 and (eta(5)-C5H5)2VCl2 and four ring-substituted derivatives in HT-29 (colon cancer) and MCF-7 (breast cancer) cell lines is reported. "
01/01/2017 - "This area has attracted many researchers as well as the pharmaceutical industry due to the promising results of some metallocenes, in particular ferrocene compounds, in breast cancer and malaria."

01/01/2018 - "Bent metallocenes (BM) have anti-tumor properties but they face a serious drug efficacy problem due to poor aqueous solubility and rapid hydrolysis under physiological conditions. "
01/01/2017 - "Bent metallocenes Cp2MCl2 (M = Ti, V, Nb, Mo) are known to exhibit cytotoxic activity against a variety of cancer types. "
12/01/2012 - "Metallocenes as Target Specific Drugs for Cancer Treatment."
01/01/2023 - "Self-Immolative Amphiphilic Poly(ferrocenes) for Synergistic Amplification of Oxidative Stress in Tumor Therapy."
06/01/1981 - "Tumor inhibition by metallocenes: activity against leukemias and detection of the systemic effect."

08/16/2016 - "In order to examine whether the length of the bridging chain in ansa-ferrocenes affects their antiproliferative activity against MDA-MB-231 triple negative breast cancer cell lines (TNBC), we synthesized derivatives of the type 1-[bis-(4-hydroxyphenyl)]methylidene-[n]ferrocenophane and 1-[(4-hydroxyphenyl)-phenyl]methylidene-[n]ferrocenophane with n = 3, 4, 5. We found that the derivatives of [3]ferrocenophane, the compounds with the shortest bridging chains, are the most active. "
08/16/2016 - "The length of the bridging chain in ansa-metallocenes influences their antiproliferative activity against triple negative breast cancer cells (TNBC)."

03/01/1994 - "[Protective action of 5-hydroxy-6-methyluracil and ferrocenes in nitrite-ion poisoning]."