rhoC GTP-Binding Protein

A rho GTP-binding protein that is prenylated (see PROTEIN PRENYLATION) at its C-terminus and cycles between the cytoplasm and plasma membrane, linking receptor signaling pathways with assembly of FOCAL ADHESIONS; STRESS FIBERS; and contractile ring formation during CYTOKINESIS. It is overexpressed in proliferating and metastatic tumor cells.

Also Known As:

ras Homolog Family Member C; rhoC GTPase; GTP-Binding Protein, rhoC; rhoC GTP Binding Protein

Networked: 43 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Merajver, Sofia D: 16 articles (01/2021 - 01/2002)
2.	van Golen, Kenneth L: 14 articles (01/2017 - 01/2002)
3.	Kleer, Celina G: 6 articles (01/2012 - 01/2004)
4.	Bao, Liwei: 5 articles (01/2021 - 10/2011)
5.	Wu, Zhi-Fen: 4 articles (06/2010 - 01/2004)
6.	Wu, Zhifen: 3 articles (01/2021 - 10/2011)
7.	Yates, Joel A: 3 articles (01/2021 - 06/2016)
8.	Keller, Evan T: 3 articles (01/2020 - 09/2006)
9.	Lehman, Heather L: 3 articles (01/2017 - 10/2012)
10.	Wu, Zhi Fen: 3 articles (12/2016 - 01/2002)

Related Diseases

1.	Inflammatory Breast Neoplasms 07/01/2011 - "Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overexpressing inflammatory breast cancer (IBC) cells however, RhoC activity was increased. " 12/19/2016 - "Macrophages Enhance Migration in Inflammatory Breast Cancer Cells via RhoC GTPase Signaling." 10/01/2012 - "Regulation of inflammatory breast cancer cell invasion through Akt1/PKBα phosphorylation of RhoC GTPase." 06/01/2010 - "This work shows that RHOC and RHOA play different roles in cell-matrix adhesion, motility, and invasion of MDA-MB-231 and reaffirms the crucial role of RHOC-GTPase in inflammatory breast cancer cell invasion." 10/15/2000 - "RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype."
2.	Neoplasms (Cancer) 01/01/2021 - "Thus, we set out to study how RhoA- and RhoC-GTPase influence the cell-cell junctions in aggressive breast cancers. " 01/01/2002 - "In a comprehensive study aimed at identifying the molecular mechanisms responsible for the unique IBC phenotype, our laboratory identified overexpression of RhoC GTPase in over 90% of IBC tumors in contrast to 36% of stage-matched non-IBC tumors. " 08/22/2010 - "However, RhoC GTPase is expressed in metastatic cancer cells at relatively low levels. " 12/01/2008 - "Recent IBC research has examined two genes, RhoC GTPase and WISP3, which are concordantly altered in the majority of IBC tumors but not in non-IBC specimens. " 03/01/2004 - "In our laboratory, overexpression of RhoC GTPase was observed to be specific for IBC tumors, but not for stage-matched, non-IBC tumors. "
3.	Neoplasm Metastasis (Metastasis) 01/01/2012 - "Here we identify RhoC GTPase as an important regulator of BCSC metastasis, and present evidence suggesting that RhoC also modulates the frequency of BCSCs within a population. " 09/01/2006 - "LNCaP(col) cells were found to express increased levels of the metastasis-promoting RhoC GTPase compared with parental LNCaP. " 12/01/2008 - "This study investigated the effect of RhoC GTPase on the proliferation and metastasis of cervical cancer cells, SiHa cells, in vitro. " 01/01/2021 - "Ras homolog family member C (RhoC) is an important component of intracellular signal transduction and its overexpression has been reported to be involved in regulating tumor proliferation, invasion, and metastasis in various malignant tumors. " 07/01/2016 - "Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. "
4.	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/01/2008 - "This study investigated the effect of RhoC GTPase on the proliferation and metastasis of cervical cancer cells, SiHa cells, in vitro. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2020 - "In the present study, we found CNF1 induced bladder cancer cells to secrete vascular endothelial growth factor (VEGF) through activating Ras homolog family member C (RhoC), leading to subsequent angiogenesis in the bladder cancer microenvironment. "

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