Deubiquitinating Enzyme CYLD

A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.

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Networked: 34 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Naumann, Michael: 3 articles (01/2017 - 01/2013)
2.	Nishanth, Gopala: 3 articles (01/2017 - 01/2013)
3.	Schlüter, Dirk: 3 articles (01/2017 - 01/2013)
4.	Jono, Hirofumi: 3 articles (02/2014 - 08/2007)
5.	Hayashi, Hiroki: 2 articles (01/2019 - 03/2008)
6.	Nakagami, Hironori: 2 articles (01/2019 - 03/2008)
7.	Rakugi, Hiromi: 2 articles (01/2019 - 03/2008)
8.	Takami, Yoichi: 2 articles (01/2019 - 03/2008)
9.	Schmid, Ursula: 2 articles (01/2017 - 05/2015)
10.	Wang, Xu: 2 articles (01/2017 - 05/2015)

Related Diseases

1.	Neuroinflammatory Diseases 01/01/2021 - "Therefore, we explored whether EA improved CYLD protein expression to regulate microglial polarization-mediated neuroinflammation and the potential mechanisms in an ischemic stroke model. "
2.	Ischemic Stroke 01/01/2021 - "Therefore, we explored whether EA improved CYLD protein expression to regulate microglial polarization-mediated neuroinflammation and the potential mechanisms in an ischemic stroke model. "
3.	Neoplasms (Cancer) 09/01/2015 - "The CYLD protein is also dysfunctional in various sporadic cancers and we discuss how such dysfunction relates to the role of CYLD in regulating key cellular pathways. " 05/01/2015 - "The deubiquitinating enzyme CYLD is an important tumor suppressor and inhibitor of immune responses. " 03/01/2013 - "The findings showed that CYLD protein expression in tumor tissue was associated with CYLD gene expression (P=0.031). " 04/01/2018 - "miR-501 overexpression and CYLD protein downregulation were positively correlated with poor differentiation, tumor size, International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis. " 04/01/2014 - "Multiple familial trichoepithelioma: report of a Chinese family not associated with a mutation in the CYLD gene and CYLD protein expression in the trichoepithelioma tumor tissue."
4.	Retinal Detachment (Retinal Detachments) 08/01/2017 - "This study was designed to evaluate the coregulatory effects of the deubiquitinating enzyme cylindromatosis on the apoptosis and necroptosis of photoreceptor cells in experimental retinal detachment. "
5.	Familial cylindromatosis 03/01/2008 - "Here, we examined the potential role of the deubiquitinating enzyme CYLD (cylindromatosis), mutation of which has been reported to cause familial cylindromatosis. " 10/01/2007 - "A novel mutation of CYLD in a Chinese family with multiple familial trichoepithelioma and no CYLD protein expression in the tumour tissue." 08/14/2003 - "Familial cylindromatosis is caused by mutations in a gene encoding the CYLD protein of previously unknown function. " 04/01/2014 - "Multiple familial trichoepithelioma: report of a Chinese family not associated with a mutation in the CYLD gene and CYLD protein expression in the trichoepithelioma tumor tissue." 03/12/2010 - "Here, we identify the deubiquitinating enzyme CYLD, the familial cylindromatosis tumor suppressor gene, as a negative regulator of proximal events in Wnt/beta-catenin signaling. "

Related Drugs and Biologics

1.	NF-kappa B (NF-kB)
2.	Transcription Factors (Transcription Factor)
3.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
4.	Ubiquitin
5.	Amyloid Precursor Protein Secretases (beta-Secretase)
6.	Catenins
7.	beta Catenin
8.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
9.	Cadherins (E-Cadherin)
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)