Aldo-Keto Reductase Family 1 Member C2

Aldo-keto reductase that functions with 5-alpha and 5-beta-steroid reductases to convert steroid hormones into the 3-alpha or 5-alpha and 3-alpha or 5-beta-tetrahydrosteroid, including 5-ALPHA-DIHYDROTESTOSTERONE to ANDROSTANE-3,17-DIOL. It also binds to BILE ACIDS. Mutations in the AKR1C2 gene are associated with Type 8 DISORDER OF SEX DEVELOPMENT, 46,XY (SRXY8).

Also Known As:

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Qian, Li-Hua: 1 article (06/2018)
2.	Ren, Ding-Yu: 1 article (06/2018)
3.	Shao, Jie-Bao: 1 article (06/2018)
4.	Wang, Yu-Chao: 1 article (06/2018)
5.	Xu, Chun-Hua: 1 article (06/2018)
6.	Zhang, Qian: 1 article (06/2018)
7.	Zhang, Xiu-Wei: 1 article (06/2018)
8.	Higashiyama, Shigeki: 1 article (03/2014)
9.	Kikugawa, Tadahiko: 1 article (03/2014)
10.	Miura, Noriyoshi: 1 article (03/2014)

Related Diseases

1.	Urinary Bladder Neoplasms (Bladder Cancer) 03/01/2014 - "Cisplatin resistance by induction of aldo-keto reductase family 1 member C2 in human bladder cancer cells." 03/01/2014 - "To clarify the mechanism underlying cisplatin resistance in bladder cancer, the present study examined the role of the aldo-keto reductase family 1 member C2 (AKR1C2) protein on chemoresistance using a human bladder cancer cell line. "
2.	Neoplasms (Cancer) 02/01/2023 - "In vitro wound healing, proliferation, migration, and invasion assays and in vivo tumor xenograft and metastasis assays were performed to determine the functional importance of aldo-keto reductase family 1 member C2 (AKR1C2). " 06/01/2023 - "Aldo-keto reductase family 1 member C2 (AKR1C2) as a member of the human ARKs family, can regulate steroid hormones and is abnormally expressed in many cancers. "
3.	Neoplasm Metastasis (Metastasis) 02/01/2023 - "In vitro wound healing, proliferation, migration, and invasion assays and in vivo tumor xenograft and metastasis assays were performed to determine the functional importance of aldo-keto reductase family 1 member C2 (AKR1C2). "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 06/01/2018 - "Dihydrodiol dehydrogenase 2 (DDH2) plays an important role in pathogenesis of non-small-cell lung cancer (NSCLC). " 06/01/2018 - "Diagnostic value of serum dihydrodiol dehydrogenase 2 levels in patients with non-small-cell lung cancer."

Related Drugs and Biologics

1.	Aldo-Keto Reductase Family 1 Member C2
2.	Cisplatin (Platino)
3.	Steroids
4.	Hormones (Hormone)