Bronchial Thermoplasty

Thermal destruction of the excess bronchial SMOOTH MUSCLE tissue with heat delivered through a catheter assembly attached to a BRONCHOSCOPE. It is often used to control BRONCHIAL HYPERREACTIVITY in severe ASTHMA for better AIRWAY MANAGEMENT.

Also Known As:

Networked: 313 relevant articles (50 outcomes, 28 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Castro, Mario: 22 articles (01/2022 - 01/2010)
2.	Laviolette, Michel: 16 articles (01/2022 - 03/2007)
3.	Cox, Gerard: 15 articles (07/2021 - 06/2005)
4.	Langton, David: 14 articles (04/2022 - 01/2017)
5.	Facciolongo, Nicola: 12 articles (05/2022 - 07/2014)
6.	Bonta, Peter I: 12 articles (12/2021 - 01/2017)
7.	Thomson, Neil C: 12 articles (01/2019 - 03/2007)
8.	Annema, Jouke T: 11 articles (11/2021 - 01/2017)
9.	Chanez, Pascal: 10 articles (01/2019 - 12/2014)
10.	Galeone, Carla: 9 articles (05/2022 - 07/2014)

Related Diseases

1.	Asthma (Bronchial Asthma) 09/24/2018 - "In randomized controlled trials, bronchial thermoplasty (BT) has been proven to reduce symptoms in severe asthma, but the mechanisms by which this is achieved are uncertain as most studies have shown no improvement in spirometry. " 01/01/2017 - "Bronchial thermoplasty has also shown reductions in asthma exacerbations and improved quality of life; however, it is unclear which patients may respond best to this intervention." 01/01/2017 - "Several recent studies have shown significant improvement in clinical outcomes of bronchial thermoplasty for asthma, including symptom control, reduction in exacerbation and hospitalization rates, improved quality of life, and reduction in number of working days or school days lost due to asthma. " 03/01/2023 - "Bronchial thermoplasty (BT) is effective in some severe asthma patients; however, the specific asthma phenotypes that produce a good response to BT are not fully understood. " 01/01/2022 - "All subgroups demonstrated clinically significant improvement, suggesting that bronchial thermoplasty improves asthma control in different asthma phenotypes. "
2.	Cough 03/01/2020 - "Although bronchial thermoplasty was performed in the both upper lobes, cough and dyspnoea gradually appeared 2 weeks later. " 01/01/2018 - "Bronchial Thermoplasty for Severe Asthmatic Cough." 01/01/2023 - "Bronchial thermoplasty (BT) may be effective in improving cough severity and cough-related quality of life in severe uncontrolled asthma. " 01/01/2023 - "Despite the relatively short follow-up period in our previous study, we had reported that increased cough reflex sensitivity (CRS) may predict the efficacy of bronchial thermoplasty (BT) for treating asthma. " 01/01/2023 - "Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics."
3.	Emphysema 01/01/2022 - "Leading the charge are bronchial thermoplasty for severe refractory asthma and uni-directional valves for severe emphysema with hyperinflation: both have received regulatory approvals in the United Kingdom and United States. " 12/01/2014 - "Interventional pulmonology for asthma and emphysema: bronchial thermoplasty and bronchoscopic lung volume reduction." 11/01/2011 - "The guideline covers transbronchial needle aspiration and endobronchial ultrasound-guided transbronchial needle aspiration, electrocautery/diathermy, argon plasma coagulation and thermal laser, cryotherapy, cryoextraction, photodynamic therapy, brachytherapy, tracheobronchial stenting, electromagnetic navigation bronchoscopy, endobronchial valves for emphysema and bronchial thermoplasty for asthma." 03/31/2021 - "The main techniques with available data from randomised controlled trials are: 1) bronchial thermoplasty in asthma; 2) valves, coils and thermal vapor ablation in emphysema; and 3) targeted lung denervation in COPD. " 11/01/2011 - "Distal airway obstruction has also been targeted with bronchial thermoplasty treatment of refractory asthma and with bronchoscopic lung volume reduction for the management of severe emphysema. "
4.	Inflammation (Inflammations) 01/01/2017 - "Data from these recent studies have shown reduction in ASM following bronchial thermoplasty and changes in inflammation patterns. " 01/01/2019 - "The place of bronchial thermoplasty in the management of severe asthma is not certain, although some experts propose that bronchial thermoplasty should be considered for patients with severe asthma associated with non-type 2 inflammation or who fail to respond favorably to biologic therapies targeting type 2 inflammation. " 01/01/2022 - "Airway Inflammation Before and After Bronchial Thermoplasty in Severe Asthma." 11/01/2021 - "These differences are linked with inflammation and asthma severity, and they can be reversed by bronchial thermoplasty." 11/01/2021 - "We determined whether transcriptomes of BECs reflect heterogeneity in inflammation and severity in asthma, and whether this was affected in BECs from patients with severe asthma after their regeneration by bronchial thermoplasty. "
5.	Airway Remodeling 12/01/2019 - "Bronchial thermoplasty (BT) is to date the only therapy that provides a lasting reduction in airway wall remodelling. " 07/01/2017 - "For the patients with severe asthma who are unresponsive to maximum medical therapy and have evidence of airway remodeling, bronchial thermoplasty has demonstrated long-term improvement in quality of life and reduction in severe exacerbations and health care utilization. " 10/05/2023 - "Bronchial thermoplasty (BT), a bronchoscopic treatment for severe asthma, targets airway remodeling. " 01/01/2022 - "Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty." 05/26/2020 - "Objective: To investigate the effects of bronchial thermoplasty (BT) on airway remodeling, asthma control and quality of life in patients with severe asthma. "

Related Drugs and Biologics

1.	Adrenal Cortex Hormones (Corticosteroids)
2.	salicylhydroxamic acid (SHAM)
3.	Bronchodilator Agents (Bronchodilators)
4.	Sclerosing Solutions (Sclerosing Agents)
5.	Dexmedetomidine
6.	3- (2- (4- azidobenzamidino)ethyl)- 5- hydroxyindole (SABA)
7.	prednylidene (Pred)
8.	Azithromycin (Zithromax)
9.	Roflumilast
10.	Omalizumab (Xolair)

Related Therapies and Procedures

1.	Therapeutics
2.	Denervation
3.	Biological Therapy
4.	Aftercare (After-Treatment)
5.	Anesthesia