Abstract | PURPOSE OF REVIEW: RECENT FINDINGS: Several Th2 biomarkers exist for the detection of eosinophilic disease; however, the best biomarker for clinical practice is debatable depending upon local resources. Currently, there are three federal drug agency-approved biologic agents ( omalizumab, mepolizumab and reslizumab) to treat severe asthma with frequent exacerbations despite standard medical therapy. Several others are either in clinical trials or in the development phase for the treatment of eosinophilic asthma. To date, agents targeting neutrophilic inflammation have been largely unsuccessful. Bronchial thermoplasty has emerged as an option for the treatment of severe asthma. SUMMARY: The appropriate selection of patients through the use of eosinophilic biomarkers has led to significant reductions in exacerbations with the use of mAb therapy. Bronchial thermoplasty has also shown reductions in asthma exacerbations and improved quality of life; however, it is unclear which patients may respond best to this intervention.
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Authors | Amber J Oberle, Praveen Mathur |
Journal | Current opinion in pulmonary medicine
(Curr Opin Pulm Med)
Vol. 23
Issue 3
Pg. 254-260
(05 2017)
ISSN: 1531-6971 [Electronic] United States |
PMID | 28319473
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Anti-Asthmatic Agents
(therapeutic use)
- Asthma
(drug therapy, surgery)
- Bronchial Thermoplasty
- Humans
- Precision Medicine
- Quality of Life
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