Histamine H4 Receptors

G-Protein-coupled histamine receptors that are expressed primarily in BONE MARROW as well as in peripheral tissues and organs. They are expressed by immune cells that include EOSINOPHILS; T-CELLS; DENDRITIC CELLS; and MAST CELLS.

Also Known As:

Networked: 150 relevant articles (8 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thurmond, Robin L: 17 articles (11/2018 - 09/2005)
2.	Medina, Vanina A: 12 articles (01/2022 - 01/2011)
3.	Stark, Holger: 10 articles (01/2021 - 01/2009)
4.	Dunford, Paul J: 9 articles (07/2014 - 10/2005)
5.	Nicoud, Melisa B: 7 articles (01/2022 - 04/2017)
6.	Masini, Emanuela: 7 articles (02/2020 - 11/2014)
7.	Werfel, Thomas: 7 articles (01/2020 - 01/2009)
8.	Táquez Delgado, Mónica A: 6 articles (01/2022 - 01/2019)
9.	Neumann, Detlef: 6 articles (06/2021 - 01/2010)
10.	Kieć-Kononowicz, Katarzyna: 6 articles (01/2021 - 01/2015)

Related Diseases

1.	Inflammation (Inflammations) 08/01/2016 - "The aim of this study was to determine if the histamine H4 receptor (H4R) mediates NK cell chemotaxis and whether it influences interplay between NK cells and dendritic cells during the early phase of allergic inflammation. " 03/01/2012 - "Several studies underlined the critical role of histamine H4 receptor (H4R) in inflammation, thus H4 modulators have been suggested as promising drug candidates in inflammatory diseases. " 10/17/2023 - "The histamine H4 receptor (H4R) is mainly expressed in cellular populations and plays a vital role in inflammation and immunological responses. " 06/06/2021 - "The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut." 06/01/2019 - "Emerging evidence supports the important role of histamine H4 receptor (H4R) in allergic inflammation. "
2.	Allergic Rhinitis 10/01/2010 - "To observe expression and distribution of histamine H4 receptor in nasal mucosa in normal people and allergic rhinitis patients,and understand role of histamine H4 receptor in allergic rhinitis. " 10/01/2010 - "[Different expression of histamine H4 receptor in nasal mucosa in allergic rhinitis patients]." 06/01/2010 - "[Effect of histamine H4 receptor and its antagonist on allergic rhinitis in rats]." 06/01/2009 - "Effect of histamine H4 receptor antagonist on allergic rhinitis in mice." 01/01/2017 - "Histamine H4 receptor gene polymorphisms: a potential predictor of oral H1 antihistamine efficacy for allergic rhinitis."
3.	Melanoma (Melanoma, Malignant) 10/01/2011 - "The aim of this study was to investigate the presence of histamine H4 receptor (H4R) in human melanoma cells and its associated biological processes. " 12/01/2013 - "Functional presence of histamine H4 receptor (H4R) was demonstrated in human melanoma cell lines and biopsies. " 04/18/2017 - "Histamine therapeutic efficacy in metastatic melanoma: Role of histamine H4 receptor agonists and opportunity for combination with radiation."
4.	Triple Negative Breast Neoplasms 01/01/2022 - "Histamine H4 Receptor Expression in Triple-negative Breast Cancer: An Exploratory Study." 01/01/2020 - "The aim of this work was to improve the knowledge of the role of histamine in breast cancer by assessing the therapeutic efficacy of histamine and histamine H4 receptor (H4R) ligands in a triple-negative breast cancer (TNBC) model developed in immunocompetent hosts. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2021 - "Impact of histamine H4 receptor deficiency on the modulation of T cells in a murine breast cancer model." 10/01/2020 - "Though preclinical evidence suggests a role for histamine H4 receptor (H4R) in breast cancer growth, its function in the EMT is less known. " 10/01/2020 - "Histamine H4 receptor agonists induce epithelial-mesenchymal transition events and enhance mammosphere formation via Src and TGF-β signaling in breast cancer cells." 01/01/2019 - "Immunomodulatory role of histamine H4 receptor in breast cancer." 01/01/2015 - "Histamine H4 receptor: insights into a potential therapeutic target in breast cancer."

Related Drugs and Biologics

1.	Histamine (Histamine Dihydrochloride)
2.	Ligands
3.	Histamine Antagonists (Antihistamines)
4.	1- ((5- chloro- 1H- indol- 2- yl)carbonyl)- 4- methylpiperazine
5.	Pyrimidines
6.	toreforant
7.	Histamine H3 Receptors (Histamine H3 Receptor)
8.	Biomarkers (Surrogate Marker)
9.	Histamine Receptors (Histamine Receptor)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Analgesia