Transcription Factor 4

A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.

Also Known As:

Networked: 377 relevant articles (2 outcomes, 42 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Baratz, Keith H: 8 articles (01/2021 - 01/2012)
2.	Wieben, Eric D: 8 articles (01/2021 - 01/2012)
3.	Fautsch, Michael P: 6 articles (01/2021 - 01/2017)
4.	Aleff, Ross A: 5 articles (01/2021 - 01/2012)
5.	Maher, Brady J: 5 articles (01/2021 - 01/2016)
6.	Maier, Wolfgang: 5 articles (07/2015 - 01/2011)
7.	Mössner, Rainald: 5 articles (07/2015 - 01/2011)
8.	Rujescu, Dan: 5 articles (07/2015 - 08/2009)
9.	Patel, Sanjay V: 4 articles (01/2021 - 08/2014)
10.	Sepp, Mari: 4 articles (10/2020 - 11/2015)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 01/01/2019 - "This study aimed to investigate the synergistic effect of octamer-binding transcription factor 4 and sex determining region Y-box 2 (OCT4&SOX2)-specific cytotoxic T lymphocytes (CTLs) and programmed cell death protein 1 (PD-1) inhibitor on killing lung cancer stem-like cells (LCSCs) and their efficacy in treating drug-resistant lung cancer (DRLC) mice. " 01/01/2018 - "We find that it directly affects the stability and function of octamer-binding transcription factor 4 (Oct4), known to drive the stemness of lung cancer cells. " 01/01/2018 - "CD133, octamer-binding transcription factor 4 (OCT-4) and Nanog have been suggested to be markers of CICs in lung cancer. " 04/20/2008 - "The fluorescence signal of TCF-4 protein was conspicuous in lung cancer cells, primarily in cell nuclei, but extremely low in HBE. " 04/20/2008 - "Immunofluorescence was used to examine the TCF-4 protein expression level and subcellular localization in lung cancer cells and HBE (human normal bronchi epithelium) cells. "
2.	Lymphoma (Lymphomas) 02/01/2014 - "Cisplatin promoted self-renewal and survival of CSCs in vitro, as seen by an increase in the number of orospheres in ultralow attachment plates and induction in B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) and octamer-binding transcription factor 4 expression. " 11/19/2019 - "The most frequently activated pathways in eCSC are Wingless-INT (Wnt)/β-catenin, Notch1, and Hedghog, with a high expression of self-renewal transcription factors like Octamer binding transcription factor 4 (OCT), B Lymphoma Mo-MLV Insertion Region 1 Homolog (BMI1), North American Network Operations Group Homebox protein (NANOG), and SRY-Box 2 (SOX2). " 01/01/2018 - "Western blot analysis indicated that IDB increased the expression of B‑cell lymphoma 2 (Bcl‑2), signal transducer and activator of transcription‑3, Nanog, octamer‑binding transcription factor 4, E‑cadherin, proliferating cell nuclear antigen, cyclinD1 and cyclinD3, and decreased the expression of Bcl‑2‑associated X protein, cleaved caspase‑3, N‑cadherin, vimentin and α‑smooth muscle actin. " 08/15/2023 - "Also, cotadutide enhanced transcriptional factors related to islet cell transdifferentiation, decreasing aristaless-related homeobox and increasing the paired box 4 and 6, pancreatic and duodenal homeobox 1, v-maf musculoaponeurotic fibrosarcoma oncogene family protein A, neurogenin 3, and neurogenic differentiation 1. In addition, cotadutide improved the proliferating cell nuclear antigen, NK6 homeobox 1, B cell leukemia/lymphoma 2, but lessening caspase 3. Furthermore, cotadutide mitigated the endoplasmic reticulum (ER) stress-responsive genes, reducing transcription factor 4, DNA-damage-inducible transcript 3, and growth arrest and DNA-damage-inducible 45. "
3.	Fibrosarcoma 11/10/2023 - "The mRNA and protein expression levels of β-cell-specific factors [Pancreatic duodenal homeobox-1 (Pdx1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog A(MafA)] and endocrine progenitor cell-specific factors [Octamer binding transcription factor 4(Oct4), Nanog] were measured by Real Time-PCR and Western blot. " 08/15/2023 - "Also, cotadutide enhanced transcriptional factors related to islet cell transdifferentiation, decreasing aristaless-related homeobox and increasing the paired box 4 and 6, pancreatic and duodenal homeobox 1, v-maf musculoaponeurotic fibrosarcoma oncogene family protein A, neurogenin 3, and neurogenic differentiation 1. In addition, cotadutide improved the proliferating cell nuclear antigen, NK6 homeobox 1, B cell leukemia/lymphoma 2, but lessening caspase 3. Furthermore, cotadutide mitigated the endoplasmic reticulum (ER) stress-responsive genes, reducing transcription factor 4, DNA-damage-inducible transcript 3, and growth arrest and DNA-damage-inducible 45. "
4.	B-Cell Leukemia (Leukemia, B Cell) 08/15/2023 - "Also, cotadutide enhanced transcriptional factors related to islet cell transdifferentiation, decreasing aristaless-related homeobox and increasing the paired box 4 and 6, pancreatic and duodenal homeobox 1, v-maf musculoaponeurotic fibrosarcoma oncogene family protein A, neurogenin 3, and neurogenic differentiation 1. In addition, cotadutide improved the proliferating cell nuclear antigen, NK6 homeobox 1, B cell leukemia/lymphoma 2, but lessening caspase 3. Furthermore, cotadutide mitigated the endoplasmic reticulum (ER) stress-responsive genes, reducing transcription factor 4, DNA-damage-inducible transcript 3, and growth arrest and DNA-damage-inducible 45. "
5.	Neoplasms (Cancer) 09/01/2014 - "In this study, we investigated the expression of Octamer-binding transcription factor 4 (Oct4) and Nanog, two stem cell markers, in 47 neuroblastic tumors by immunohistochemistry and correlated their expression by other prognostic factors especially with NMYC amplification using both fluorescent and chromogenic in situ hybridization methods. " 10/01/2023 - "Spalt-like transcription factor 4 (SALL4), as a proto-oncogene, is expressed in various tumors and correlates with poor prognosis of patients. " 01/01/2023 - "Octamer-binding transcription factor 4 (Oct4) is closely related to the occurrence and development of cancer. " 01/01/2023 - "Increasing evidence supports a relationship between E twenty-six variant transcription factor 4 (ETV4) and several cancers, but no pan-cancer analysis has been reported. " 01/01/2023 - "Octamer-binding transcription factor 4 (Oct-4) and its activation targets are overexpressed in the tumor stem cells of various types of tumors, and this expression is associated with the pathogenesis, development, and poor prognosis of tumors. "

Related Drugs and Biologics

1.	Proliferating Cell Nuclear Antigen (PCNA)
2.	Caspase 3 (Caspase-3)
3.	Staphylococcal Protein A (Protein A)
4.	cotadutide
5.	Proteins (Proteins, Gene)
6.	Transcription Factors (Transcription Factor)
7.	Catenins
8.	Basic Helix-Loop-Helix Transcription Factors
9.	Biomarkers (Surrogate Marker)
10.	Tumor Biomarkers (Tumor Markers)

Related Therapies and Procedures

1.	Adjuvant Chemotherapy
2.	Therapeutics
3.	Drug Therapy (Chemotherapy)
4.	Chemoradiotherapy
5.	Radiotherapy