2-Hydroxypropyl-beta-cyclodextrin

Derivative of beta-cyclodextrin that is used as an excipient for steroid drugs and as a lipid chelator.

Also Known As:

2 Hydroxypropyl-beta-cyclodextrin; HP-beta-CD; HPbetaCD; Hydroxypropyl Betadex; Hydroxypropyl-beta-cyclodextrin; beta-Hydroxypropylcyclodextrin; 2 Hydroxypropyl beta cyclodextrin; Betadex, Hydroxypropyl; Hydroxypropyl beta cyclodextrin; beta Hydroxypropylcyclodextrin

Networked: 82 relevant articles (13 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ito, Yoshimasa: 4 articles (01/2010 - 07/2004)
2.	Bácskay, Ildikó: 2 articles (02/2019 - 01/2019)
3.	Fehér, Pálma: 2 articles (02/2019 - 01/2019)
4.	Fenyvesi, Ferenc: 2 articles (02/2019 - 01/2019)
5.	Fenyvesi, Éva: 2 articles (02/2019 - 01/2019)
6.	Malanga, Milo: 2 articles (02/2019 - 01/2019)
7.	Rusznyák, Ágnes: 2 articles (02/2019 - 01/2019)
8.	Szente, Lajos: 2 articles (02/2019 - 01/2019)
9.	Ujhelyi, Zoltán: 2 articles (02/2019 - 01/2019)
10.	Vasvári, Gábor: 2 articles (02/2019 - 01/2019)

Related Diseases

1.	Poisoning 10/01/2016 - "The aim of this study was to investigate the efficacy of 2-hydroxypropyl-beta-cyclodextrin (HPBCD) as an antidotal treatment for the in vivo cardiovascular effects of amitriptyline poisoning. " 12/01/2004 - "Sprague-Dawley rats were used to evaluate the efficacy of hydroxypropyl-beta-cyclodextrin as treatment of aldicarb poisoning in rats. " 10/01/2016 - "Effects of 2-Hydroxypropyl-Beta-Cyclodextrin on Cardiovascular Signs of Amitriptyline Poisoning in a Rat Model." 12/01/2004 - "Evaluation of hydroxypropyl-beta-cyclodextrin in the treatment of aldicarb poisoning in rats."
2.	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 02/01/2019 - "2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the formulation of drugs and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. " 01/01/2019 - "2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is utilized in the formulation of pharmaceutical products and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. " 09/01/2018 - "A new methodology, based on high resolution liquid chromatography with light scatterin detector, is applied to analyze Hydroxypropyl-beta-Cyclodextrin (HPβCD) in urine samples of a child affected by Niemann-Pick Type C disease. " 05/01/2017 - "Early experience with compassionate use of 2 hydroxypropyl-beta-cyclodextrin for Niemann-Pick type C disease: review of initial published cases." 01/01/2017 - "2-Hydroxypropyl-beta-cyclodextrin (HPβCD) has gained recent attention as a potential therapeutic intervention in the treatment of the rare autosomal-recessive, neurodegenerative lysosomal storage disorder Niemann-Pick Disease Type C1 (NPC1). "
3.	Pain (Aches) 01/01/2008 - "* Single-dose HPbetaCD diclofenac 3.75, 9.4, 18.75, 25, 37.5, 50 and 75 mg administered by intravenous bolus injection produced significantly greater responses than placebo for total pain relief (TOTPAR) over 6 hours or pain intensity at 4 hours in the treatment of moderate or severe postoperative dental pain in randomized, double-blind trials. " 10/01/2009 - "The significantly lower pain response at the 100 microg dose in the Tween compared with the HP-beta-CD formulation is likely to be due to limitations in solubility at the 100 microg level. " 07/01/2007 - "At 15 minutes, more patients given HPbetaCD diclofenac sodium than PG-BA diclofenac sodium reported 30% reduction in pain intensity (52% vs. 21%, P = .0022). " 07/01/2007 - "Primary endpoints were superiority of HPbetaCD diclofenac sodium to placebo and noninferiority of HPbetaCD diclofenac sodium to PG-BA diclofenac sodium with respect to total pain relief over 4 hours (TOTPAR4) on a 0 to 100-mm visual analog scale (VAS). " 07/01/2007 - "We compared the efficacy and safety of an IV HPbetaCD diclofenac sodium bolus, a 30-minute PG-BA diclofenac sodium infusion, and placebo in post-molar extraction pain. "
4.	Wounds and Injuries (Trauma) 04/27/2021 - "In this study, we prepared an antibacterial wound dressing, consisting of visible light-cured methacrylated collagen (ColMA) hydrogel and a 2-hydroxypropyl-beta-cyclodextrin (HP-β-CD)/triclosan (TCS) complex (CD-ic-TCS), and evaluated its wound healing effects in vivo. "
5.	Herpes Labialis (Fever Blister) 01/01/2013 - "A randomized, double-blind, placebo-controlled study to test the efficacy of topical 2-hydroxypropyl-Beta-cyclodextrin in the prophylaxis of recurrent herpes labialis."

Related Drugs and Biologics

1.	Itraconazole (Sporanox)
2.	2-Hydroxypropyl-beta-cyclodextrin
3.	Diclofenac (SR 38)
4.	zinc- tetrakis(p- sulfonatophenyl)porphyrin
5.	Hydrogels
6.	Triclosan (pHisoHex)
7.	Cyclodextrins
8.	Collagen
9.	Amitriptyline (Elavil)
10.	Cholesterol

Related Therapies and Procedures

1.	Therapeutics
2.	Investigational Therapies (Experimental Therapy)
3.	Spinal Injections
4.	General Anesthesia
5.	Intravenous Infusions