Metal-Organic Frameworks

Supramolecular networks that consist of ordered arrangements of organic electron donor linkers (usually ditopic or polytopic organic carboxylates) and metal cations. They can have an extremely high surface area and adjustable pore size that allows for the insertion of other molecules capable of various functions such as catalysis, capture of carbon dioxide, and drug delivery.

Also Known As:

Covalent Organic Framework; Porous Coordination Networks; Porous Coordination Polymers; Coordination Networks, Porous; Coordination Polymer, Porous; Coordination Polymers, Porous; Framework, Covalent Organic; Framework, Metal Organic; Framework, Metal-Organic; Frameworks, Metal-Organic; Metal Organic Frameworks; Networks, Porous Coordination; Organic Framework, Covalent; Organic Framework, Metal; Polymer, Porous Coordination; Polymers, Porous Coordination; Metal Organic Framework; Metal-Organic Framework; Porous Coordination Polymer

Networked: 891 relevant articles (21 outcomes, 54 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lin, Wenbin: 16 articles (01/2021 - 04/2014)
2.	Li, Na: 14 articles (07/2022 - 06/2019)
3.	Tang, Bo: 14 articles (07/2022 - 10/2017)
4.	Meng, Xianwei: 11 articles (09/2022 - 01/2018)
5.	Wu, Qiong: 11 articles (09/2022 - 01/2018)
6.	Ni, Kaiyuan: 11 articles (10/2020 - 01/2016)
7.	Tan, Longfei: 10 articles (09/2022 - 01/2018)
8.	Pan, Wei: 10 articles (07/2022 - 06/2019)
9.	Zhang, Xian-Zheng: 10 articles (01/2022 - 10/2015)
10.	Xie, Zhigang: 9 articles (05/2022 - 11/2016)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2023 - "Functionalized metal-organic frameworks (MOFs) that integrate targeted tumor imaging and drug delivery are expected to significantly enhance the therapeutic efficacy of cancer. " 01/01/2019 - "Though metal-organic frameworks (MOFs) have been emerged as promising delivery vehicles, the therapeutic efficacy of MOFs in cancer treatment is limited by the lack of a general approach for the preparation of stimuli-responsive multifunctional MOFs. " 01/01/2020 - "Herein, we report the design of a mitochondria-targeted metal-organic framework (MOF) that greatly increases the efficacy of a model cancer drug, reducing the required dose to less than 1% compared to the free drug and ca. 10% compared to the nontargeted MOF. " 01/01/2023 - "Although the potential of metal-organic framework (MOF) nanoparticles as drug delivery systems (DDS) for cancer treatment has been established by numerous studies, their clinical applications are still limited due to relatively poor biocompatibility. " 04/01/2018 - "In this study, we have reported a biocompatible metal-organic framework (MOF) with ultra-high surface area, which we have shown to have uses as both a cancer treatment delivery system and for environmental applications. "
2.	Poisoning 01/01/2018 - "Considering the insufficient efficacy of the currently available detoxification treatments, a pioneering oral detoxifying adsorbent agent based on a single biocompatible metal-organic framework (MOF) is here proposed for the efficient decontamination of drugs commonly implicated in accidental or voluntary poisoning. " 09/02/2020 - "Copper Metal-Organic Framework Surface Catalysis: Catalyst Poisoning, IR Spectroscopic, and Kinetic Evidence Addressing the Nature and Number of the Catalytically Active Sites En Route to Improved Applications." 04/25/2015 - "Self-standing thiol (-SH) groups within a Zr(IV)-based metal-organic framework (MOF) anchor Pd(II) atoms for catalytic applications: the spatial constraint prevents the thiol groups from sealing off/poisoning the Pd(II) center, while the strong Pd-S bond precludes Pd leaching, enabling multiple cycles of heterogeneous catalysis to be executed." 10/01/2021 - "Transition metal and nitrogen co-doped carbon-based catalysts (TM-N-C) have become the most promising catalysts for Pt/C due to their wide range of sources, low cost, high catalytic activity, excellent stability and strong resistance to poisoning, especially Fe-N-C metal-organic frameworks (MOFs), which are some of the most promising precursors for the preparation of Fe-N-C catalysts due to their inherent properties, such as their highly ordered three-dimensional framework structure, controlled porosity, and tuneable chemistry. " 09/15/2023 - "Herein, a highly dispersed N-doped carbon nanofibers (CNFs) -loaded NiCo non-precious metal alloy electrocatalyst based on metal-organic frameworks (MOFs) was prepared, which conferred excellent methanol oxidation activity and resistance to carbon monoxide (CO) poisoning through a surface electronic structure modulation strategy. "
3.	Breast Neoplasms (Breast Cancer) 11/15/2022 - "Therefore, the growing search for the development of new treatments for breast cancer has been developed lately as well as drug delivery systems such as biocompatible metal-organic Frameworks (bio-MOFs). " 01/01/2022 - "Reversing breast cancer bone metastasis by metal organic framework-capped nanotherapeutics via suppressing osteoclastogenesis." 01/01/2021 - "Functional metal-organic framework-based nanocarriers for accurate magnetic resonance imaging and effective eradication of breast tumor and lung metastasis." 12/01/2020 - "Metal-Organic Framework Nanoparticles for Ameliorating Breast Cancer-Associated Osteolysis." 06/11/2023 - "To overcome this challenge, researchers have developed PIP@MIL-100(Fe), an organic metal-organic framework (MOF) that encapsulates PIP for breast cancer treatment. "
4.	Ovarian Neoplasms (Ovarian Cancer) 04/09/2014 - "We report here the first use of nanoscale metal-organic frameworks (NMOFs) for the co-delivery of cisplatin and pooled small interfering RNAs (siRNAs) to enhance therapeutic efficacy by silencing multiple drug resistance (MDR) genes and resensitizing resistant ovarian cancer cells to cisplatin treatment. " 04/09/2014 - "Nanoscale metal-organic frameworks for the co-delivery of cisplatin and pooled siRNAs to enhance therapeutic efficacy in drug-resistant ovarian cancer cells." 06/29/2023 - "Metal-organic framework-encapsulated dihydroartemisinin nanoparticles induces apoptotic cell death in ovarian cancer by blocking ROMO1-mediated ROS production." 01/01/2022 - "GSK-J1-loaded, hyaluronic acid-decorated metal-organic frameworks for the treatment of ovarian cancer." 01/01/2022 - "In this study, we designed and prepared hyaluronic acid-decorated metal-organic frameworks for the targeted delivery of GSK-J1, a JMJD3 demethylase inhibitor (HA@MOF@GSK-J1) for the synergistic treatment of carboplatin-resistant ovarian cancer. "
5.	Melanoma (Melanoma, Malignant) 01/01/2023 - "Multifunctional Covalent Organic Framework-Based Microneedle Patch for Melanoma Treatment." 05/01/2023 - "DDTC-Cu(I) based metal-organic framework (MOF) for targeted melanoma therapy by inducing SLC7A11/GPX4-mediated ferroptosis." 04/25/2022 - "In this study, the potential of using MIL-100(Fe) metal-organic framework (MOF) for loading and controlling the release of dacarbazine (DTIC) was evaluated for in vitro treatment of melanoma. " 01/01/2023 - "Microneedle-Assisted Transdermal Delivery of 2D Bimetallic Metal-Organic Framework Nanosheet-Based Cascade Biocatalysts for Enhanced Catalytic Therapy of Melanoma." 01/01/2022 - "It is discovered that ZIF-8 (zinc imidazolate metal-organic frameworks ) can induce abrupt intracellular Zn2+ elevation preferentially in melanoma cells, and then achieve effective glycolysis blockade through "Zn2+ interference"-triggered decrease of NAD+ and inactivation of GAPDH, making it a powerful tumor energy nanoinhibitor. "

Related Drugs and Biologics

1.	Copper
2.	1-phenyl-3,3-dimethyltriazene (PDT)
3.	Hyaluronic Acid (Hyaluronan)
4.	Iron
5.	Enzymes
6.	Folic Acid (Vitamin M)
7.	Porphyrins
8.	Drug Carriers
9.	Cisplatin (Platino)
10.	Cannabidiol

Related Therapies and Procedures

1.	Therapeutics
2.	Photothermal Therapy
3.	Immunotherapy
4.	Photochemotherapy (Photodynamic Therapy)
5.	Precision Medicine