Invasive Fungal Infections

Mycoses which manifest as infections of deep tissue or blood.

Also Known As:

Invasive Mycoses; Disseminated Fungal Infections; Fungal Infection, Disseminated; Fungal Infection, Invasive; Infection, Disseminated Fungal; Infection, Invasive Fungal; Invasive Fungal Infection; Mycoses, Invasive; Disseminated Fungal Infection

Networked: 2693 relevant articles (211 outcomes, 364 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Bacterial Infections and Mycoses: 1
  - Mycoses: 11300
    - Invasive Fungal Infections: 2693

Related Diseases

1.	Neutropenia
2.	Infections
3.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
4.	Candidiasis (Moniliasis)
5.	Mycoses (Diseases, Fungus)

Experts

1.	Walsh, Thomas J: 42 articles (01/2021 - 01/2002)
2.	Cornely, Oliver A: 40 articles (03/2022 - 05/2003)
3.	Perfect, John R: 34 articles (03/2020 - 03/2002)
4.	Kontoyiannis, Dimitrios P: 32 articles (10/2022 - 10/2003)
5.	Groll, Andreas H: 22 articles (10/2019 - 03/2002)
6.	Lass-Flörl, Cornelia: 21 articles (10/2022 - 04/2004)
7.	Ullmann, Andrew J: 21 articles (02/2020 - 05/2003)
8.	Wiederhold, Nathan P: 17 articles (02/2021 - 12/2007)
9.	Lewis, Russell E: 16 articles (01/2022 - 08/2002)
10.	Maertens, Johan: 16 articles (12/2021 - 09/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Invasive Fungal Infections:

1.	Amphotericin B (Amphotericin)FDA LinkGeneric 01/01/2015 - "Amphotericin B (AmB) is a highly efficacious therapeutic for invasive fungal infections and protozoal diseases. " 03/01/2009 - "Amphotericin B (AmB) is the gold standard of antifungal treatment for the most severe invasive mycoses. " 01/01/2022 - "Early diagnosis and treatment with Amphotericin B are potentially curative options for this invasive fungal infection and can led to better outcome." 06/15/2017 - "Amphotericin B can play a key role in treating severe invasive mycoses as the incidence of antifungal resistance is very low combined with a high efficacy against a wide range of fungi. " 04/01/2006 - "Amphotericin B is an important therapeutic agent for the treatment of invasive fungal infections but is associated with significant toxicities and high acquisition costs. "
2.	Fluconazole (Zonal)FDA LinkGeneric 04/01/2010 - "Efficacy of fluconazole prophylaxis for prevention of invasive fungal infection in extremely low birth weight infants." 10/17/2007 - "Meta-analysis of data from four trials that compared prophylactic fluconazole versus placebo revealed a statistically significant reduction in the risk of invasive fungal infection in the infants who received prophylaxis [typical relative risk: 0.23 (95% confidence interval 0.11, 0.46); typical risk difference: -0.11 (95% confidence interval -0.16, -0.06); number needed to treat: 9 (95% confidence interval 6, 17)]. " 02/01/2013 - "Targeted fluconazole prophylaxis may be beneficial in VLBW neonates who receive care in NICUs with lower rates of invasive fungal infections. " 08/01/2005 - "Fluconazole prophylaxis appeared to be beneficial in preventing invasive fungal infection in VLBW infants." 04/27/2023 - "Fluconazole is effective in preventing invasive fungal infections in very low birth weight infants without serious adverse effects. "
3.	posaconazole FDA Link 01/01/2018 - "Posaconazole was ranked highest in effectiveness for primary prophylaxis, being the most favorable in terms of (i) the RR for reduction of invasive fungal infection (0.19; 95% confidence interval [CI], 0.11 to 0.36) and (ii) the probability of being the best option (94% of the cumulative ranking). " 12/01/2011 - "Posaconazole prophylaxis has proven highly effective in preventing invasive fungal infections, despite relatively low serum concentrations. " 01/01/2006 - "A large number of experimental animal models of invasive fungal infections has demonstrated the potent and broad-spectrum efficacy of posaconazole in vivo, both in normal and in immunocompromised animals. " 02/01/2015 - "Due to sustained, higher drug concentrations, the new posaconazole formulations hold promise for greater efficacy in antifungal prophylaxis and bring opportunity for further study in the treatment of invasive mycoses. " 01/01/2022 - "Prophylaxis with posaconazole (PP) is effective in the prevention of invasive fungal infections in immunocompromised adult patients. "
4.	Antifungal AgentsIBA 12/29/1995 - "Identification of state-of-the-art management is also a difficult task for the clinical scientist involved in the assessment of optimal strategies to prevent and to treat those invasive fungal infections, although major progress has occurred in the last 5 years with the development of new, safe, and effective antifungal agents. " 01/01/2020 - "Despite the high morbidity and mortality of invasive fungal infections (IFIs), effective and safe antifungal agents are rather limited. " 02/01/2014 - "For neonates with invasive fungal infections, the development of new antifungal agents has significantly improved therapeutic outcomes in recent years. " 04/01/2012 - "However, in the last several years, the range of antifungal agents has been significantly extended, which have led to an improvement in the treatment of invasive fungal infection in this population. " 09/01/1993 - "In view of the above, the study of improved and less toxic antifungal agents, and the evaluation of new clinical and laboratory methods for an early diagnosis, have been the major goals in research on the opportunistic invasive fungal infections in the last years."
5.	Voriconazole (Vfend)FDA LinkGeneric 08/01/2012 - "Challenging recommended oral and intravenous voriconazole doses for improved efficacy and safety: population pharmacokinetics-based analysis of adult patients with invasive fungal infections." 10/01/2012 - "The effect of therapeutic drug monitoring on safety and efficacy of voriconazole in invasive fungal infections: a randomized controlled trial." 05/01/2003 - "Voriconazole is an effective and well-tolerated treatment for refractory or less-common invasive fungal infections." 04/01/2013 - "There are increasing insights into voriconazole concentrations that are safe and effective for treatment of invasive fungal infections. " 11/01/2023 - "Current study aims to explore the correlation between the administered dose and efficacy of voriconazole in the treatment of invasive fungal infection (IFI). "
6.	liposomal amphotericin B FDA Link 12/01/2007 - "with L-AmB, can be a safe and effective strategy to reduce the frequency of invasive fungal infections in selected high-risk patients and to obtain significant cost savings for the hospital." 01/01/2006 - "Based on existing evidence from animal models of invasive fungal infections and the earlyclinical experience, L-AmB used athigher doses for invasive fungal infections is a new treatment option." 02/01/2001 - "Efficacy of amphotericin B lipid complex in the treatment of invasive fungal infections in immunosuppressed paediatric patients." 07/01/2012 - "There have been no published studies evaluating the efficacy and safety of weekly liposomal amphotericin B as secondary prophylaxis in leukemic patients with invasive fungal infections (IFIs). " 02/01/2008 - "Safety of a weekly high dose of liposomal amphotericin B for prophylaxis of invasive fungal infection in immunocompromised patients: PROPHYSOME Study."
7.	Itraconazole (Sporanox)FDA LinkGeneric 12/01/2006 - "Itraconazole intravenously followed by oral capsules is thus tolerated and effective in severely ill patients with proven invasive fungal infection." 12/15/2003 - "New evidence and the anti-Aspergillus efficacy of itraconazole prompted a new look at the data for the prevention of invasive fungal infections. " 12/01/2006 - "An open-labeled, non-competitive, multicenter phase IV study was conducted to investigate the efficacy and safety of itraconazole administered intravenously for the treatment of invasive fungal infections in Chinese patients. " 08/01/2021 - "SUBA®-itraconazole is well-tolerated, associated with rare breakthrough invasive fungal infection, and lower cost. " 07/01/2013 - "Itraconazole remains a useful drug for the management of allergic and invasive mycoses worldwide. "
8.	Caspofungin (Cancidas)FDA Link 12/01/2010 - "Caspofungin was found to be an effective treatment of probable and proven invasive fungal infections in patients following SOT in Germany." 02/01/2013 - "These results suggest that caspofungin, either alone or in combination, should be considered an effective and safe option for the treatment of invasive mycoses in patients with severe hematological disorders." 12/01/2012 - "In routine clinical practice conditions, caspofungin is effective and safe for the treatment of invasive fungal infections (IC/IA). " 06/01/2010 - "This study was designed to determine clinical outcomes with caspofungin in patients with proven or probable invasive fungal infection (IFI) after a solid organ transplant (SOT) procedure. " 10/11/2023 - "She was treated with caspofungin due to developing invasive fungal infection of Candida tropicalis. "
9.	EchinocandinsIBA 05/01/2006 - "The echinocandins are a new class of antifungals, developed in response to the need for safe and effective antifungals for the treatment of invasive fungal infections. " 06/01/2017 - "The majority of invasive fungal infections observed in non-neutropenic patients hospitalized in an intensive care unit are caused by Candida spp and current guidelines recommend echinocandins as the first-line treatment. " 11/01/2004 - "As little is known about the relationship between the pharmacokinetics and the pharmacodynamics of the echinocandins, increased incorporation of these principles in experimental and clinical studies is an important objective that will benefit the treatment and prophylaxis of life-threatening invasive fungal infections in immunocompromised patients." 06/12/2023 - "Despite a targeted antimycotic prophylaxis using echinocandins, invasive fungal infections occurred in 12% (26/214) of the patients. " 01/01/2023 - "When invasive fungal infections occur, echinocandins still represent the first therapeutic choice. "
10.	Micafungin (FK463)FDA Link 03/31/2009 - "Micafungin is a new and very useful pharmacological tool for the treatment of invasive mycoses with a wide antifungal spectrum for the most common pathogenic fungi. " 12/01/2014 - "Efficacy of micafungin in pediatric immunocompromised patients with invasive fungal infection." 05/01/2020 - "Treatment of invasive fungal infections in intensive care units with micafungin: The MYRIADE study." 06/01/2019 - "Effectiveness and Safety of Micafungin in Managing Invasive Fungal Infections among Patients in Greece with Hematologic Disorders: The ASPIRE Study." 01/01/2019 - "Use of Micafungin for the Prevention and Treatment of Invasive Fungal Infections in Everyday Pediatric Care in France: Results of the MYRIADE Study."

Therapies and Procedures

1.	Therapeutics 12/30/2020 - "Invasive fungal infections (IFIs) are associated with high mortality rates and timely appropriate antifungal therapy is essential for good outcomes. " 06/01/2011 - "Invasive fungal infections are associated with significant morbidity and mortality and preemptive antifungal therapy has been found to improve survival. " 02/01/2009 - "Improvement in microbiology and histopathology specimen processing as well as rapid interventions such as initiation of anti-fungal therapy or CVC line removal could improve diagnostic rates and clinical outcomes of invasive fungal infections." 01/01/2021 - "Prophylactic antifungal therapy is widely adopted clinically for critical patients and effective in reducing the morbidity of invasive fungal infection and improves outcomes of those diagnosed patients; however, it is not associated with higher overall survival. " 01/01/2022 - "While mammalian models remain the gold standard to study invasive mycoses, mini-host invertebrate models have provided complementary platforms for explorative investigations of fungal pathogenesis, host-pathogen interplay, and antifungal therapy. "
2.	Drug Therapy (Chemotherapy) 01/01/2017 - "Despite the relatively high efficacy of antifungal drugs, invasive fungal infections (IFIs) are still associated with tremendous morbidity and mortality, since late diagnosis makes an antifungal drug therapy inefficient. " 04/01/2004 - "Evidence-based studies using these new agents are accumulating, and they are assuming important roles in the pharmacotherapy of invasive fungal infections in seriously ill and complex patients." 04/01/1993 - "The study drug was started at initiation of chemotherapy and continued until recovery of neutrophil count, development of proven or suspected invasive fungal infection, or the occurrence of a drug-related toxicity. " 12/29/2022 - "Due to an increasing number of patients at risk (i.e., those with a highly compromised immune system and/or receiving aggressive chemotherapy treatment), invasive fungal infections (IFI) are increasingly being reported and associated with high mortality rates. " 12/01/2022 - "Invasive fungal infections (IFI) are life-threatening complications of intensive chemotherapy treatment, with the incidence in pediatric patients ranging from 2% to 21%. "
3.	Liver Transplantation 11/01/2008 - "This strategy is also effective for the prevention of invasive fungal infection in liver transplant recipients. " 08/01/2021 - "Breakthrough invasive fungal infection after liver transplantation in patients on targeted antifungal prophylaxis: A prospective multicentre study." 01/01/2020 - "The aim of the present study was to describe the prevalence of invasive fungal infections and their predisposing factors in a singlecenter cohort of patients who received liver transplant. " 12/01/2015 - "As part of a randomized, double-blind trial of antifungal prophylaxis in liver transplant recipients at risk for invasive fungal infections (IFIs), GM and BG were assessed in 199 patients at baseline (enrollment) and weekly thereafter for the duration of study drug. " 06/12/2023 - "Invasive Fungal Infections: The Early Killer after Liver Transplantation."
4.	Stem Cell Transplantation 05/01/2016 - "This case shows that molecular genetic-based methods may be effective for detecting undetermined invasive fungal infections in stem cell transplantation settings." 10/01/2006 - "The aim of the study was to assess whether polymorphisms of these genes are associated with invasive fungal infections (IFIs) following allogeneic stem cell transplantation (allo-SCT). " 01/01/2019 - "Invasive fungal infections are one of the main infectious complications in allogeneic stem cell transplantation (SCT). " 01/01/2019 - "Outcome of non-mold effective anti-fungal prophylaxis in patients at high-risk for invasive fungal infections after allogenic stem cell transplantation." 07/01/2017 - "Paediatric recipients of haematopoietic stem cell transplantation (HSCT) have a high risk for invasive fungal infections. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/01/2021 - "Invasive fungal infections (IFI) remain a major challenge among immune compromised patients, particularly those undergoing allogeneic hematopoietic bone marrow transplantation (HSCT) or solid organ transplant (SOT) both presenting high morbidity and mortality rates. " 08/01/2014 - "Risk factors for higher mortality were allogeneic bone-marrow transplantation, modified SOFA, NIV failure, severe ARDS, and invasive fungal infection. " 11/01/2003 - "Invasive fungal infections have became one of the principal obstacles to successful solid organ and bone marrow transplantation. " 12/01/2000 - "Among the serious complications associated with bone marrow transplantation are invasive fungal infections caused by organisms such as Candida and Aspergillus species and end-organ disease caused by cytomegalovirus (CMV). " 11/01/2000 - "Invasive fungal infections after bone marrow transplantation have an extremely poor prognosis. "