Splicing Factor U2AF

An RNA splicing factor that performs a critical function in both constitutive and enhancer-dependent RNA SPLICING. It recruits RIBONUCLEOPROTEIN, U2 SMALL NUCLEAR to the splice site and mediates interactions between it, the RNA molecule, and other splicing factors for accurate 3'-splice site selection.

Also Known As:

U2AF 65; U2AF Splicing Factor; U2AF(65); Factor U2AF, Splicing; Factor, U2AF Splicing; Splicing Factor, U2AF; U2AF, Splicing Factor

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cho, Sunghee: 1 article (08/2015)
2.	Jang, Ha Na: 1 article (08/2015)
3.	Liu, Yongchao: 1 article (08/2015)
4.	Loh, Tiing Jen: 1 article (08/2015)
5.	Moon, Heegyum: 1 article (08/2015)
6.	Ohn, Takbum: 1 article (08/2015)
7.	Shen, Haihong: 1 article (08/2015)
8.	Zheng, Xuexiu: 1 article (08/2015)
9.	Zhou, Jianhua: 1 article (08/2015)
10.	Agrawal, Anant A: 1 article (12/2014)

Related Diseases

1.	Inborn Genetic Diseases (Disease, Hereditary) 12/09/2014 - "The D231V amino acid change restores U2AF(65) affinity for two mutated splice sites that cause human genetic diseases and successfully promotes splicing of a defective retinitis pigmentosa-causing transcript. "
2.	Neurofibromatoses (Neurofibromatosis) 12/09/2014 - "We found that neurofibromatosis- or retinitis pigmentosa-causing mutations in the 5' regions of Py tracts severely reduce U2AF(65) affinity. "
3.	Retinitis Pigmentosa (Pigmentary Retinopathy) 12/09/2014 - "We found that neurofibromatosis- or retinitis pigmentosa-causing mutations in the 5' regions of Py tracts severely reduce U2AF(65) affinity. " 12/09/2014 - "The D231V amino acid change restores U2AF(65) affinity for two mutated splice sites that cause human genetic diseases and successfully promotes splicing of a defective retinitis pigmentosa-causing transcript. "
4.	Neoplasms (Cancer) 05/01/2009 - "The expression profile of a panel of RNA-binding proteins (heterogeneous ribonucleoprotein (hnRNP) A1, hnRNP C1/C2, hnRNP H, hnRNP I, ASF/SF2, SR proteins, HuR and U2AF(65)) and markers of differentiation, proliferation and neoplasia (cytokeratin (CK) 13, CK-14, proliferating cell nuclear antigen (PCNA), Syndecan-1 and p16INK4a) were analyzed in 50 formalin fixed paraffin embedded cervical tissues using immunohistochemistry. "
5.	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 08/11/2015 - "In this report, we show that U2AF(65) stimulates alternative exon skipping in spinal muscular atrophy (SMA)-related survival motor neuron (SMN) pre-mRNA. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Splicing Factor U2AF
3.	Syndecan-1 (Syndecan 1)
4.	Dioxygenases
5.	Small Interfering RNA (siRNA)
6.	Heterogeneous-Nuclear Ribonucleoproteins (Informatin)
7.	Proliferating Cell Nuclear Antigen (PCNA)
8.	RNA-Binding Proteins (RNA-Binding Protein)
9.	RNA Precursors (Precursor, mRNA)
10.	Ribonucleoproteins