Breast Cancer Lymphedema

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical treatment (e.g., MASTECTOMY) or radiation treatment of breast cancer.

Also Known As:

Breast Cancer Related Lymphedema; Breast Cancer Treatment-Related Lymphedema; Breast Cancer-Related Arm Lymphedema; Post-mastectomy Lymphedema; Postmastectomy Lymphedema; Breast Cancer Lymphedemas; Breast Cancer Related Arm Lymphedema; Breast Cancer Treatment Related Lymphedema; Lymphedema, Breast Cancer; Lymphedema, Post-mastectomy; Lymphedema, Postmastectomy; Lymphedemas, Postmastectomy; Post mastectomy Lymphedema; Post-mastectomy Lymphedemas; Postmastectomy Lymphedemas

Networked: 328 relevant articles (32 outcomes, 79 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Lymphedema (Milroy Disease)
2.	Edema (Dropsy)
3.	Pain (Aches)
4.	Second Primary Neoplasms (Neoplasms, Second)
5.	Weight Loss (Weight Reduction)

Experts

1.	Chang, Edward I: 6 articles (03/2022 - 02/2018)
2.	Schaverien, Mark V: 5 articles (01/2021 - 01/2017)
3.	Akita, Shinsuke: 4 articles (01/2022 - 08/2016)
4.	Kubota, Yoshitaka: 4 articles (01/2022 - 08/2016)
5.	Mitsukawa, Nobuyuki: 4 articles (01/2022 - 08/2016)
6.	Ridner, Sheila H: 4 articles (01/2022 - 04/2006)
7.	Tokumoto, Hideki: 4 articles (01/2022 - 08/2016)
8.	Donahue, Manus J: 4 articles (01/2022 - 01/2016)
9.	Jeong, Ho Joong: 4 articles (01/2022 - 10/2013)
10.	Eyigör, Sibel: 4 articles (06/2021 - 12/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Breast Cancer Lymphedema:

1.	Cytidine Diphosphate (CDP)IBA 12/01/2018 - "Complex decongestive physiotherapy (CDP) is an effective treatment for patients with breast cancer-related lymphedema (BCRL). " 12/01/2019 - "Background: The purpose of the study was to investigate the effect of using Kinesio Taping® (KT) on anastomotic regions along with complex decongestive physiotherapy (CDP) in patients with breast cancer-related lymphedema (BCRL). " 10/01/2013 - "The efficacy of complex decongestive physiotherapy (CDP) and predictive factors of lymphedema severity and response to CDP in breast cancer-related lymphedema (BCRL)." 12/01/2022 - "Background: This study compared rates of progression to chronic breast cancer-related lymphedema (defined as ≥ 10% arm volume change from baseline requiring complex decongestive physiotherapy [CDP]) following an intervention for subclinical lymphedema (S-BCRL) triggered by bioimpedance spectroscopy (BIS) or by tape measurement (TM). "
2.	phytobacteriomycin (PBM)IBA 08/30/2022 - "This research investigated the efficacy of clinical use of LLLT (PBM) in the treatment of metastatic breast cancer-related lymphedema. " 01/01/2018 - "This study aimed to determine the feasibility of conducting a full scale randomized controlled trial investigating the effectiveness of low level laser therapy (LLLT), also known as photobiomodulation (PBM) therapy, used in addition to conventional therapy, for managing breast cancer related lymphedema (BCRL). " 06/01/2021 - "There is limited evidence that PBM therapy is cost-effective in the prevention and treatment of specific cancer treatment-related toxicities, namely, OM and breast cancer-related lymphedema. "
3.	Proteins (Proteins, Gene)FDA Link 01/01/2016 - "Assessment of lymphatic impairment and interstitial protein accumulation in patients with breast cancer treatment-related lymphedema using CEST MRI." 01/01/2019 - "Breast cancer related lymphedema (BCRL) is a chronic condition characterized by an abnormal accumulation of protein-rich fluid in tissues resulting in swelling of the upper limb or trunk after treatment. " 05/01/2004 - "The aim of the study was to use dual-isotope lymphoscintigraphy in healthy volunteers and women with breast cancer-related lymphedema (BCRL) to detect and quantify transport of radiolabeled protein from a subcutaneous injection depot to local blood vessels as a potential mechanism of protection against edema resulting from treatment to the axilla. "
4.	Neutralizing AntibodiesIBA 09/18/2021 - "The aim of this study was to test the efficacy of QBX258, a monoclonal IL4/IL13 neutralizing antibody, in women with breast cancer-related lymphedema (BCRL). "
5.	Interleukin-13IBA 09/18/2021 - "The aim of this study was to test the efficacy of QBX258, a monoclonal IL4/IL13 neutralizing antibody, in women with breast cancer-related lymphedema (BCRL). "
6.	Interleukin-4 (Interleukin 4)IBA 09/18/2021 - "The aim of this study was to test the efficacy of QBX258, a monoclonal IL4/IL13 neutralizing antibody, in women with breast cancer-related lymphedema (BCRL). "
7.	IsotopesIBA 05/01/2004 - "The aim of the study was to use dual-isotope lymphoscintigraphy in healthy volunteers and women with breast cancer-related lymphedema (BCRL) to detect and quantify transport of radiolabeled protein from a subcutaneous injection depot to local blood vessels as a potential mechanism of protection against edema resulting from treatment to the axilla. "
8.	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 11/09/2020 - "This study attempts to verify both the efficacy of activity-oriented proprioceptive antiedema therapy (TAPA), as compared to conventional treatments such as DLT or Complex Physical Therapy (CPT), as well as its efficiency in terms of cost-effectiveness, for patients affected by breast cancer-related arm lymphedema. "
9.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 10/26/2021 - "Indocyanine green lymphangiography is superior to clinical staging in breast cancer-related lymphedema." 01/01/2023 - "The authors reviewed indocyanine green (ICG) lymphography images of all patients who presented to their institution for evaluation of breast cancer-related lymphedema. " 01/01/2023 - "Accessory Lymphatic Drainage Pathways on Indocyanine Green Lymphography in Patients with Breast Cancer-Related Lymphedema." 01/01/2022 - "Relationship Between the Circumference Difference and Findings of Indocyanine Green Lymphography in Breast Cancer-Related Lymphedema." 03/26/2021 - "Prospective Validation of Indocyanine Green Lymphangiography Staging of Breast Cancer-Related Lymphedema."
10.	Therapeutic UsesIBA 03/01/2020 - "Although there have been some reports that hyperbaric oxygen therapy (HBOT) is effective in treating breast cancer-related lymphedema (BCRL), controversy regarding its therapeutic effects remains.We" 10/01/2013 - "Ultrasonographic evaluation of therapeutic effects of complex decongestive therapy in breast cancer-related lymphedema." 06/15/2020 - "It can be concluded that both virtual reality and proprioceptive neuromuscular facilitation have a beneficial therapeutic effect on edema in patients with unilateral postmastectomy lymphedema; neither method was found to be superior, except virtual reality was found to be superior to proprioceptive neuromuscular facilitation in motivating patients and providing visual feedback. "

Therapies and Procedures

1.	Therapeutics 01/01/2020 - "To determine whether complete decongestive therapy (CDT) used in breast cancer-related lymphedema affects muscle strength in the affected arm while assessing the efficacy of the therapy itself. " 05/01/2019 - "Efficacy of self-administered complex decongestive therapy on breast cancer-related lymphedema: a single-blind randomized controlled trial." 02/01/2019 - "The aim of this prospective clinical study was to compare the long-term efficacy of complex decongestive therapy (CDT) in obese and nonobese patients with breast cancer-related lymphedema (BCRL). " 11/01/2018 - "Efficacy of scrambler therapy on breast cancer-related lymphedema." 07/01/2022 - "The aims of this study were to compare the effects of compression therapy and routine nursing during the treatment of breast cancer-related lymphedema and to provide a basis for better clinical decision-making. "
2.	Mammaplasty (Breast Reconstruction) 07/01/2023 - "Our results suggest that the method of immediate breast reconstruction might be associated with the development of postmastectomy lymphedema." 07/01/2023 - "Whether the breast reconstruction modality could influence the long-term development of post-mastectomy lymphedema has been little investigated. " 07/01/2023 - "Association of the breast reconstruction modality with the development of postmastectomy lymphedema: A long-term follow-up study." 06/13/2023 - "In this review, we highlight the most recent research on the current practices of omental-based breast reconstruction techniques and their use in postmastectomy lymphedema. " 06/13/2023 - "Current Research on the Use of the Omental Flap in Breast Reconstruction and Post-Mastectomy Lymphedema: A Focus on Omental-Vascularized Lymph Node Transfer."
3.	Mastectomy (Mammectomy) 01/01/2018 - "The aim of this study was to analyse the effect of a nursing intervention in increasing the therapeutic self-care demand in patients with breast cancer-related lymphedema after a mastectomy. " 08/14/2023 - "Breast cancer-related lymphedema is a condition occurring after a partial or full mastectomy, where there is a buildup of interstitial fluid in the body, particularly in the upper limb. " 08/01/2023 - "The Development of Breast Cancer-Related Lymphedema After Mastectomy in a Rural Population." 08/30/2022 - "Breast cancer-related lymphedema (BCRL) is a frequent issue that arises after mastectomy surgery in women and compromises physical and mental function. " 01/01/2021 - "The association of breast cancer-related lymphedema after unilateral mastectomy with shoulder girdle kinematics and upper extremity function."
4.	Manual Lymphatic Drainage 01/01/2022 - "Manual Lymphatic Drainage for Breast Cancer-related Lymphedema: A Systematic Review and Meta-analysis of Randomized Controlled Trials." 01/24/2013 - "Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials." 01/01/2000 - "Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage--a randomized study." 10/01/2023 - "The Effect of Manual Lymph Drainage and Compression Bandaging for Stage 2 Breast Cancer-Related Lymphedema: A Randomized Controlled Trial." 05/22/2023 - "Materials and Methods: Ten women and men with stage II breast cancer-related lymphedema underwent a CDT intensive phase for 12 days, combining Mobiderm Autofit compression garment with manual lymphatic drainage. "
5.	Physical Therapy Modalities (Physical Therapy Technique) 09/01/2022 - "The objective of this study is to compare the effectiveness of complex physical therapy combined with intermittent pneumatic compression (CPT + IPC) versus Kinesio taping (KT) for breast cancer-related lymphedema. " 03/01/2021 - "Physical therapy enhances functions and quality of life in older patients with breast cancer-related lymphedema: A prospective experimental study." 06/01/2014 - "Eight patients being followed by physical therapy for clinically diagnosed breast cancer-related lymphedema were recruited to participate in this study. " 02/01/1998 - "Pneumatic compression is a frequently prescribed physical therapy for patients affected by postmastectomy lymphedema but, despite its wide use, its efficacy has not been demonstrated in phase III studies. " 08/22/2023 - "Complex physical therapy employing self-adjusting garment (ReadyWrap®) in breast cancer-related lymphedema cases in Brazilian women: a protocol for a randomized controlled trial."