Cytochrome P450 Family 46 (CYP46)

01/01/2003 - "To study the association of polymorphic sites on CYP46 with Alzheimer disease (AD) traits and with the risk of the development of AD. "
04/01/2013 - "Association of CYP46 gene polymorphism with sporadic Alzheimer's disease in Chinese Han populations: a meta-analysis."
11/01/2009 - "Cyp46 polymorphisms in Alzheimer's disease: a review."
05/01/2006 - "Lack of association between the CYP46 gene polymorphism and Italian late-onset sporadic Alzheimer's disease."
03/01/2006 - "Association of CYP46 intron 2 polymorphism in Finnish Alzheimer's disease samples and a global scale summary."

07/01/2004 - "The aim of this study was to evaluate an intronic variation in CYP46 (intron 2, T --> C ) along with ApoE genotype as risk factors for AD and to establish the correlation between CYP46/ApoE polymorphism and disease progression. "

08/01/2010 - "The results of this study clearly demonstrate that in pathological conditions, like brain injury, Cyp46 displayed atypical expression, being expressed not only in neuronal cells, but also in microglia and astrocytes. "
08/01/2010 - "Since cholesterol homeostasis is disrupted following brain injury, in this study we examined the effect of right sensorimotor cortex suction ablation on cellular and temporal pattern of Cyp46 expression in the rat brain. "
08/01/2010 - "Brain injury induces cholesterol 24-hydroxylase (Cyp46) expression in glial cells in a time-dependent manner."

01/01/2012 - "In this research paper, our aim is to evaluate the association between the APOE, CYP46, PRNP and PRND genes and the profile of neuropsychiatric symptoms in Polish subjects with AD and mild cognitive impairment (MCI). "
11/01/2011 - "The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. "
07/01/2004 - "These findings provide direct evidence that CYP46 and ApoE polymorphisms synergically increase the risk for AD development, and influence on the rate of cognitive decline."
07/01/2004 - "In AD patients, CYP46*C along with ApoE epsilon4 genotype were associated with a higher cognitive decline at 1-year follow-up (P<0.02). "
07/01/2014 - "The combined effects of metabolic syndrome and the apolipoprotein E and CYP46 genotypes on the risk of cognitive decline has yet to be determined among Taiwanese Chinese. "

09/02/2004 - "Further, in an autopsy confirmed subset of this cohort, the proposed CYP46 risk genotype was not associated with any increase in the brain levels of amyloid-beta40, amyloid-beta42 or in the levels of amyloid plaques and neurofibrillary tangles. "