An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.
Also Known As:
Placenta Growth Factor, PLGF-1 Isoform; Placenta Growth Factor, PLGF-2 Isoform; Placenta Growth Factor, PLGF-3 Isoform; Placenta Growth Factor, PLGF-4 Isoform; Factor, Placenta Growth; Growth Factor, Placenta; Placenta Growth Factor, PLGF 1 Isoform; Placenta Growth Factor, PLGF 2 Isoform; Placenta Growth Factor, PLGF 3 Isoform; Placenta Growth Factor, PLGF 4 Isoform