Retinoic Acid Receptor alpha

A nuclear receptor protein which belongs to a family of transcription regulators of ligand-responsive regulatory proteins which include steroid hormone receptors. In addition to a C-terminal ligand-binding domain, these nuclear receptors contain a highly-conserved N-terminal zinc-finger domain that mediates binding ligand-responsive elements.

Also Known As:

Networked: 563 relevant articles (16 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pandolfi, P P: 14 articles (01/2007 - 01/2001)
2.	Ley, Timothy J: 7 articles (02/2011 - 06/2002)
3.	Kogan, Scott C: 5 articles (03/2013 - 02/2003)
4.	Chen, Zhu: 5 articles (02/2010 - 02/2002)
5.	Waxman, Samuel: 5 articles (03/2009 - 02/2002)
6.	Zelent, Arthur: 5 articles (03/2009 - 07/2005)
7.	Montesinos, Pau: 4 articles (10/2021 - 08/2008)
8.	Chen, Guo-Qiang: 4 articles (01/2019 - 12/2010)
9.	Chomienne, Christine: 4 articles (10/2015 - 11/2003)
10.	Puccetti, Elena: 4 articles (01/2012 - 04/2004)

Related Diseases

1.	Leukemia 07/01/2023 - "Total 71 patients were included in the study; among these patients, 3 were negative for both FISH for t (15,17) and RT-PCR for promyelocytic leukemia retinoic acid receptor alpha, and 36 patients with APL had white blood cell count at diagnosis >10 × 109/l. " 05/01/1993 - "Molecular studies showed rearrangements of the retinoic acid receptor alpha (RAR alpha) gene but no rearrangement of the promyelocytic leukemia gene consistent with the cytogenetic data. " 09/01/2023 - "The subsequent bone marrow biopsy confirmed the diagnosis of APL, displaying the characteristic positive promyelocytic leukemia (PML)-retinoic acid receptor alpha (RARA) t(15;17) translocation. " 10/01/2022 - "Moreover, electrochemical biosensors, developed based on various nanomaterials (NMs), can increase sensitivity to the detection of leukemia-related genes, e.g., BCR/ABL as a fusion gene and promyelocytic leukemia/retinoic acid receptor alpha (PML/RARα). " 04/01/2021 - "However, rare cases of APL show a cryptic insertion of retinoic acid receptor alpha (RARA) gene into promyelocytic leukemia (PML) gene which is negative both by fluorescence in situ hybridization (FISH) and conventional cytogenetics (CC). "
2.	Acute Promyelocytic Leukemia 10/01/1994 - "We analyzed seven patients with acute promyelocytic leukemia (APL) in hematological remission for PML-retinoic acid receptor alpha (PML-RAR alpha) fusion transcripts by RT-PCR with the sensitivity level of one APL cell in 10(5) bone marrow mononuclear cells. " 04/01/1992 - "[Retinoic acid receptor alpha gene rearrangement as specific marker of acute promyelocytic leukemia and its use in the study of cell differentiation]." 05/21/2020 - "It has been suggested that 1-2% of acute promyelocytic leukemia (APL) patients present variant rearrangements of retinoic acid receptor alpha (RARα) fusion gene, with the promyelocytic leukaemia zinc finger (PLZF)/RARα being the most frequent. " 01/22/2015 - "Acute promyelocytic leukemia (APL) is largely caused by the t(15,17) chromosome translocation, leading to the production of the PML/retinoic acid receptor alpha fusion. " 01/01/2015 - "A case of acute promyelocytic leukemia (APL) with RUNX1T1 insertion to 7q is described and compared to reported cases of APL with negative retinoic acid receptor alpha (RARA) abnormality. "
3.	Neoplasms (Cancer) 01/01/2020 - "Post-translational modification of retinoic acid receptor alpha and its roles in tumor cell differentiation." 02/01/2012 - "The bioassays indicated that compounds 1 and 2 could significantly inhibit the proliferation of cancer cell, and showed the agonist effect on the transactivity of retinoic acid receptor-alpha (RARalpha). " 03/01/1999 - "Alterations of the retinoic acid receptor alpha (RAR alpha) gene in myeloid and lymphoid malignancies." 04/10/2015 - "Retinoic acid receptor alpha (RARα) plays an essential role in the regulation of many biological processes, such as hematopoietic cell differentiation, while abnormal RARα function contributes to the pathogenesis of certain diseases including cancers, especially acute promyelocytic leukemia (APL). " 04/01/2012 - "Acute promyelocytic leukemia (APL) results from a reciprocal translocation that fuses the gene for the PML tumor suppressor to that encoding the retinoic acid receptor alpha (RARα). "
4.	Residual Neoplasm 11/01/2006 - "Patients should be assessed for minimal residual disease using polymerase chain reaction testing for promyelocytic leukemia-retinoic acid receptor alpha. " 02/01/2001 - "We studied retrospectively the clinical feasibility of minimal residual disease (MRD) monitoring by reverse transcription-polymerase chain reaction (RT-PCR) detecting the PML/retinoic acid receptor alpha (RARalpha) chimeric gene in children with acute promyelocytic leukemia (APL). " 04/01/1992 - "Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia." 05/01/1995 - "Molecular monitoring of minimal residual disease in acute promyelocytic leukemia by the polymerase chain reaction assay for the PML/RAR alpha (retinoic acid receptor-alpha) fusion transcript in patients treated with all-trans retinoic acid followed by chemotherapy." 04/01/1995 - "Minimal residual disease (MRD) was prospectively monitored at the 10(-5) level by the reverse transcriptase-polymerase chain reaction (RT-PCR) of PML-retinoic acid receptor alpha (RARA) transcripts from 27 acute promyelocytic leukemia (APL) patients who achieved complete remission (CR) with all-trans retinoic acid and chemotherapy (previously untreated patients, 15; refractory to chemotherapy or relapsed, 12). "
5.	Prostatic Neoplasms (Prostate Cancer) 01/05/2013 - "These data suggest that RASP is more effective than atRA in decreasing angiogenesis and prostate cancer cell growth and identify retinoic acid receptor alpha as the receptor through which it causes retinoic acid receptor beta up-regulation and decrease of prostate cancer cell growth." 01/01/2002 - "The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukaemia."

Related Drugs and Biologics

1.	Tretinoin (Retinoic Acid)
2.	Proteins (Proteins, Gene)
3.	Arsenic Trioxide (Trisenox)
4.	promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein
5.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
6.	Oncogene Proteins (Oncogene Protein)
7.	retinoic acid receptor beta
8.	A-Form DNA (A-DNA)
9.	Vaccines
10.	Aligeron (AS 2)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Blood Component Removal (Apheresis)