DNA Ligase ATP

ATP-dependent cellular enzyme which catalyzes DNA replication, repair and recombination through formation of internucleotide ester bonds between phosphate and deoxyribose moieties. Vertebrate cells encode three well-characterized DNA ligases, DNA ligase I, III and IV, all of which are related in structure and sequence. DNA ligases either require ATP or NAD. However, archaebacterial, viral, and some eubacterial DNA ligases are ATP-dependent.

Also Known As:

DNA Ligase I; DNA Ligase II; DNA Ligase III; DNA Ligase IIIalpha; DNA Ligase IV; DNA Ligases, ATP-Dependent; LIGIIIalpha Protein; Polydeoxyribonucleotide Synthase ATP; ATP Dependent DNA Ligase; ATP, DNA Ligase; ATP, Polydeoxyribonucleotide Synthase; ATP-Dependent DNA Ligases; DNA Ligase, ATP-Dependent; DNA Ligases, ATP Dependent; IIIalpha, DNA Ligase; Ligase ATP, DNA; Ligase I, DNA; Ligase II, DNA; Ligase III, DNA; Ligase IIIalpha, DNA; Ligase IV, DNA; Ligase, ATP-Dependent DNA; Ligases, ATP-Dependent DNA; Synthase ATP, Polydeoxyribonucleotide; ATP-Dependent DNA Ligase

Networked: 171 relevant articles (3 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tomkinson, Alan E: 6 articles (10/2016 - 01/2006)
2.	Jeggo, Penny A: 5 articles (10/2015 - 10/2004)
3.	Jeggo, P A: 5 articles (06/2008 - 08/2001)
4.	Gennery, Andrew R: 4 articles (01/2018 - 04/2014)
5.	Imai, Kohsuke: 3 articles (11/2020 - 10/2015)
6.	Banerjee, Dibyendu: 3 articles (01/2019 - 01/2017)
7.	Woodbine, Lisa: 3 articles (05/2014 - 06/2009)
8.	Ketner, Gary: 3 articles (07/2012 - 07/2007)
9.	McKinnon, Peter J: 3 articles (06/2011 - 11/2002)
10.	O'Driscoll, M: 3 articles (06/2008 - 12/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/15/2019 - "Recent advances in the targeting of human DNA ligase I as a potential new strategy for cancer treatment." 07/15/2019 - "DNA ligase III (LIG3) has been implicated in the etiology of cancer. " 01/01/2018 - "As compared to normal cells, elevated levels of human DNA ligase I (hLigI) is reported in some cancers. " 09/01/2017 - "In this review, we discuss the importance of coordination between pol β and DNA ligase I during BER, and how this could be a fundamental mechanism underlying human diseases such as cancer and neurodegeneration. " 01/01/2017 - "Hence, we identify two promising DNA Ligase I inhibitors, which can be used in biochemical and cellular assays, and could be further modified and optimised to target cancer cells. "
2.	Bloom Syndrome 06/01/1993 - "Biochemical studies with Bloom's syndrome cells have revealed an abnormal DNA ligase I activity. " 12/11/1995 - "XRCC1-His interacted equally well with DNA ligase III from Bloom syndrome, HeLa and MRC5 cells, indicating that Bloom syndrome DNA ligase III is normal in this respect. " 01/01/1994 - "Bloom syndrome and a clinically related syndrome represented by the cell line 46BR have been associated with reduction in DNA ligase I activity. " 06/20/1992 - "The patient had features similar to those of Bloom's syndrome (BS), but cell lines from BS patients do not have mutations in the DNA ligase I gene. " 12/01/1991 - "Despite this, no difference in growth between wild-type (WT) and mutant virus was detectable even in Bloom's syndrome cells which have reduced DNA ligase I activity. "
3.	LIG4 Syndrome 10/07/2016 - "DNA ligase IV deficiency is a rare primary immunodeficiency, LIG4 syndrome, often associated with other systemic features. " 02/16/2010 - "Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome." 01/01/2010 - "LIG4 syndrome arises from hypomorphic mutations in the LIG4 gene encoding DNA ligase IV; a component of the nonhomologous end-joining machinery, which represents a major mechanism of repair of double strand DNA breaks in mammals. " 07/13/2006 - "LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead to impaired but not ablated activity. " 10/15/2004 - "LIG4 syndrome patients have hypomorphic mutations in DNA ligase IV. Although four of the five identified patients display immunodeficiency and developmental delay, one patient was developmentally normal. "
4.	Genetic Translocation (Chromosomal Translocation) 06/01/2011 - "DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation." 06/01/2011 - "The canonical NHEJ pathway, including DNA ligase IV (Lig4), suppresses genomic instability and chromosomal translocations, leading to the notion that a poorly defined, alternative NHEJ (alt-NHEJ) pathway generates these rearrangements. " 01/01/2013 - "In addition to microhomology-mediated end-joining events, recent studies in mammalian cells point toward the existence of a distinct and still ill defined alternative end-joining pathway that does not appear to rely on pre-existing microhomologies and may possibly involve DNA Ligase I. Whether dependent on microhomologies or not, alternative DNA end-joining mechanisms are likely to be highly mutagenic in vivo, being able to drive telomere fusion events and cancer-associated chromosomal translocations in mouse models. "
5.	Pancreatic Neoplasms (Pancreatic Cancer) 10/15/2002 - "Induction of DNA ligase I by 1-beta-D-arabinosylcytosine and aphidicolin in MiaPaCa human pancreatic cancer cells." 11/08/2002 - "The effect of the broad-spectrum anticancer agent, cisplatin, on the expression of DNA ligase I in human pancreatic carcinoma MiaPaCa cells was examined in this study, since DNA ligase I is known to be involved in various DNA repair pathways. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)
3.	Enzymes
4.	Proteins (Proteins, Gene)
5.	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
6.	DNA Ligases (Ligases, DNA)
7.	Chromatin
8.	Antineoplastic Agents (Antineoplastics)
9.	Transforming Growth Factor beta (TGF-beta)
10.	Nucleosides

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Radiotherapy
5.	Aftercare (After-Treatment)