RNA Splicing Factors

05/31/2023 - "Our approach should be helpful in the assessment of potential cancer drug candidates which target splicing factors. "
05/12/2023 - "Our approach should be helpful in the assessment of potential cancer drug candidates which target splicing factors. "
01/01/2022 - "Hence, an in-depth study of splicing factor genes mutations' impact on pan-cancer is meaningful. "
01/01/2022 - "Many studies have proven that splicing factors are crucial for human malignant tumor development. "
02/01/2021 - "In this study, we found that G4 binding to splicing factor 3B subunit 2 (SF3B2) down-regulated STAT1 phosphorylation and ISG expression in 3D-cultured cancer cells. "

01/01/2021 - "Many studies have shown that aberrant alternative splicing (AS) can lead to tumorigenesis, and splicing factors (SFs) serve as an important function during AS. "
12/01/2006 - "The study concludes that regulation of splicing factors is likely to be important in RET-mediated thyroid carcinogenesis."
08/15/2022 - "Changes in alternative splicing (AS) and splicing factor (SF) can affect gene expression, thus playing an essential role in tumorigenesis. "
01/01/2022 - "We show that the splicing factor SRSF1 controls the plasticity of tumour cells by controlling Kras splicing and is required for CRC invasion in a mouse model of carcinogenesis. "
01/01/2022 - "ARS is mainly regulated by splicing factors, whose expression is also often dysregulated in OSCC and involved in tumorigenesis. "

01/01/2023 - "This study establishes PUF60 as a cell cycle regulator and an oncogenic splicing factor in lung cancer."
12/16/2022 - "Oncogenic KRAS alters splicing factor phosphorylation and alternative splicing in lung cancer."
01/01/2022 - "Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR-mutant lung cancer."
12/01/2020 - "Antibody-based biosensor to detect oncogenic splicing factor Sam68 for the diagnosis of lung cancer."
11/01/2019 - "The expanding list of genes known to be aberrantly spliced in lung cancer along with the altered expression of splicing factors that regulate them are providing new clues as to how lung cancer develops, and how these events can be exploited for better treatment. "

01/01/2021 - "However, compared to our understanding of splicing factor mutations in hematological malignancies, studies of splicing components and alternative splicing in normal hematopoiesis have been less well investigated. "
10/01/2020 - "Previous studies demonstrated that splicing factor mutations are recurrent events in hematopoietic malignancies with both clinical and functional implications. "
01/01/2023 - "Here, we combine current knowledge of the mechanistic and functional effects of frequently mutated splicing factors in normal hematopoiesis and the effects of their mutations in hematologic malignancies. "
01/01/2023 - "RNA splicing factors in normal hematopoiesis and hematologic malignancies: novel therapeutic targets and strategies."
12/13/2022 - "Our findings reveal a conserved vulnerability of splicing factor mutant HSPCs that could allow for their selective targeting in hematologic malignancies."

11/30/2018 - "Aberrant splicing is a hallmark of leukemias with mutations in splicing factor (SF)-encoding genes. "
10/30/2018 - "Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1."
01/01/2023 - "Although seminal studies show that splicing factor mutations and mis-splicing fuel therapy-resistant leukemia stem cell (LSC) generation in adults, splicing deregulation has not been extensively studied in pAML. "
12/01/2019 - "Cancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias, as well as in a variety of solid tumors, and confer dependence on wild-type splicing. "
01/01/2023 - "Loss of the splicing factor RBM10 augments response to venetoclax in leukemia yet is completely dispensable for normal hematopoiesis. "