Ku Autoantigen

An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.

Also Known As:

G22P1 Antigen; Ku Antigen; Ku Autoantigen, 70 kDa; Ku Autoantigen, 80 kDa; Ku Heterodimer; Ku Protein; Ku70 Antigen; Ku80 Antigen; X-ray Repair Cross-Complementing Protein 5; X-ray Repair Cross-Complementing Protein 6; XRCC5 Protein; XRCC6 Protein; Antigen, G22P1; Antigen, Ku; Antigen, Ku70; Antigen, Ku80; Autoantigen, Ku; Heterodimer, Ku; X ray Repair Cross Complementing Protein 5; X ray Repair Cross Complementing Protein 6

Networked: 73 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fritzler, M J: 2 articles (08/2016 - 02/2008)
2.	Hasty, P: 2 articles (03/2015 - 04/2009)
3.	Di Paola, Domenic: 2 articles (01/2013 - 03/2008)
4.	Rampakakis, Emmanouil: 2 articles (01/2013 - 03/2008)
5.	Zannis-Hadjopoulos, Maria: 2 articles (01/2013 - 03/2008)
6.	Hosoi, Yoshio: 2 articles (07/2005 - 09/2002)
7.	Komuro, Yasuhiro: 2 articles (07/2005 - 09/2002)
8.	Matsumoto, Yoshihisa: 2 articles (07/2005 - 09/2002)
9.	Nagawa, Hirokazu: 2 articles (07/2005 - 09/2002)
10.	Nakagawa, Keiichi: 2 articles (07/2005 - 09/2002)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2013 - "Ku protein levels, localization and association to replication origins in different stages of breast tumor progression." 08/01/2004 - "Targeting Ku protein for sensitizing of breast cancer cells to DNA-damage." 08/01/2004 - "In the present study, we have tested the efficacy of RNA aptamers against the Ku protein as molecular sensitizer of MCF-7 breast carcinoma cells to DNA-damage. " 08/01/2004 - "Thus, RNA aptamers against Ku protein show potential to sensitize MCF-7 breast carcinoma cells to DNA-damaging agents." 08/01/2004 - "We found that the presence of RNA aptamers against Ku protein enhanced etoposide-induced growth inhibition of MCF-7 breast cancer. "
2.	Asthma (Bronchial Asthma) 10/01/2020 - "Ku protein expression was dramatically reduced in the bronchial epithelium of patients with asthma as well as in human bronchial epithelial cells exposed to oxidative stress. "
3.	Neoplasms (Cancer) 01/01/2021 - "Our study demonstrates that a functional loss of Ku protein promotes an adaptive, opportunistic switch to a parasitic lifestyle in human cancer cells, providing evidence for a previously unknown mechanism of cell survival in response to severe genomic stress. " 11/01/2015 - "Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. " 04/23/2009 - "Thus, Ku80 may function outside the Ku heterodimer to influence DNA damage repair presenting the possibility that Ku80 influenced the open coding ends in a manner that suppressed a cancer-causing translocation." 09/01/2006 - "[Role of Ku protein in normal and cancer cells]." 09/15/2002 - "The expression pattern of Ku protein was correlated not only with tumor radiosensitivity but also with disease free survival. "
4.	Carcinoma (Carcinomatosis) 09/15/2002 - "The authors examined the possible role of Ku protein in determining tumor radiosensitivity and disease free survival in patients with rectal carcinoma. " 11/01/2001 - "The objective of the current study was to investigate the expression and DNA-binding activity of the Ku protein in fresh tissues from patients with bladder carcinoma and to compare it with that in nontumor tissues obtained from the same organ. " 11/01/2001 - "Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma." 10/28/2013 - "To determine the expression of the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and the Ku70/Ku80 heterodimer (Ku 70/80) in gastric carcinoma. "
5.	Neoplasm Metastasis (Metastasis) 09/01/2019 - "The aim of the present study is to explore the metastasis correlation between the expression level of XRCC5 protein in HCC cell lines with different metastatic potentials and the prognosis of patients with HCC. " 12/08/2004 - "These include six known genes, 67-kDa laminin receptor (67LR), endothelin receptor B (ENDRB), Na+/K+-ATPase, Ku antigen, interleukin-receptor-associated kinase-1 (IRAK-1) and ribosomal protein RPLA, which may contribute to the complex process of melanoma metastasis. "

Related Drugs and Biologics

1.	Nucleotide Aptamers
2.	DNA (Deoxyribonucleic Acid)
3.	Chromatin
4.	Proteins (Proteins, Gene)
5.	Autoantibodies
6.	Antibodies
7.	Autoantigens
8.	A-Form DNA (A-DNA)
9.	Topoisomerase II Inhibitors
10.	DNA-Activated Protein Kinase