Salter-Harris Fractures

Fractures involving a GROWTH PLATE.

Also Known As:

Growth Plate Fractures; Growth Plate Injuries; Fracture, Growth Plate; Fractures, Growth Plate; Fractures, Salter-Harris; Growth Plate Fracture; Growth Plate Injury; Salter Harris Fractures

Networked: 50 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Joint Diseases: 6509
  - Joint Dislocations: 216
    - Fracture Dislocation: 710
      - Salter-Harris Fractures: 50
Wounds and Injuries: 176426
- Bone Fractures: 3857
  - Fracture Dislocation: 710
    - Salter-Harris Fractures: 50
- Joint Dislocations: 216
  - Fracture Dislocation: 710
    - Salter-Harris Fractures: 50

Related Diseases

1.	Congenital Abnormalities (Deformity)
2.	Lacerations
3.	Inflammation (Inflammations)
4.	Infections

Experts

1.	Xian, Cory J: 7 articles (11/2018 - 07/2006)
2.	Chung, Rosa: 5 articles (11/2018 - 05/2009)
3.	Foster, Bruce K: 5 articles (11/2018 - 07/2006)
4.	Payne, Karin A: 3 articles (01/2022 - 01/2021)
5.	Krebs, Melissa D: 2 articles (01/2022 - 01/2022)
6.	Stager, Michael A: 2 articles (01/2022 - 01/2022)
7.	Chen, Lin: 2 articles (11/2018 - 08/2014)
8.	Xie, Yangli: 2 articles (11/2018 - 08/2014)
9.	Zhou, Xin-Fu: 2 articles (11/2018 - 07/2006)
10.	Milbrandt, Todd A: 2 articles (12/2015 - 01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Salter-Harris Fractures:

1.	HydrogelsIBA 01/01/2023 - "Finally, in vivo studies indicated that the composite hydrogel reduced bone bridge formation and improved cartilage regeneration in the rabbit model of proximal tibial growth plate injury. " 02/08/2023 - "A rat model of growth plate injury was developed to validate the effect of the GMOCS hydrogels encapsulated with BMSCs on the repair of growth plate injury. " 02/08/2023 - "Biodegradable Dual-Cross-Linked Hydrogels with Stem Cell Differentiation Regulatory Properties Promote Growth Plate Injury Repair via Controllable Three-Dimensional Mechanics and a Cartilage-like Extracellular Matrix." 01/01/2023 - "Moreover, the addition ofPCL to the scaffold provided good mechanical support, significantly reducing limbdeformities after growth plate injury compared with directly injected hydrogel. " 04/01/2022 - "Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair."
2.	Caspase 3 (Caspase-3)IBA 07/29/2013 - "Post-traumatic caspase-3 expression in the adjacent areas of growth plate injury site: a morphological study."
3.	Therapeutic UsesIBA 01/01/2022 - "The objective of this study was to examine the therapeutic effects of human mesenchymal stromal/stem cell (MSC) exosomes in a rat model of growth plate injury. "
4.	MelatoninIBA 10/01/2008 - "We observed a superior radioprotective function of melatonin over amifostine in preventing radiation-induced epiphyseal growth plate injury, without any increase in radioprotective effect by adding amifostine to melatonin." 10/01/2008 - "We compared the effects of amifostine and melatonin in preventing radiation-induced epiphyseal growth plate injury in rats. " 11/01/2003 - "The effects of melatonin, a free-radical scavenger and a general antioxidant, on radiation-induced growth plate injury have not been studied previously. "
5.	Insulin-Like Growth Factor I (IGF-1)IBA 12/01/2015 - "Treatment of growth plate injury using IGF-I-loaded PLGA scaffolds." 12/01/2015 - "The goal of this research was to develop an in vivo tissue-engineering approach for the treatment of growth plate injury via localized delivery of insulin-like growth factor I (IGF-I) from cell-free poly(lactic-co-glycolic acid) (PLGA) scaffolds. " 01/01/2023 - "Conclusion: This bilayer microsphere-based composite hydrogel with sequential controlled release of Bevacizumab and IGF-1 has promising potential for growth plate injury repair."
6.	Biocompatible Materials (Biomaterials)IBA 01/01/2022 - "Results indicate that hydrogel composition and material properties affect the differentiation tendency of MSCs in vitro, and the PEC hydrogels show promise as an injectable biomaterial for growth plate injuries." 01/01/2021 - "Biomaterials such as chitosan microgels could be a potential treatment for growth plate injuries due to their chondrogenic properties, which can be enhanced through loading with biologics. "
7.	MicrogelsIBA 01/01/2022 - "These microgels have been employed in a rat growth plate injury model and were demonstrated to promote increased cartilage tissue repair and to show complete degradation at 28 days in vivo. " 01/01/2021 - "To assess the applicability of the microgels for growth plate cartilage regeneration, they were injected into a rat growth plate injury. " 01/01/2021 - "This work demonstrates that chitosan microgels can be fabricated without solvent rinses and demonstrates their potential for the treatment of growth plate injuries." 01/01/2021 - "Biomaterials such as chitosan microgels could be a potential treatment for growth plate injuries due to their chondrogenic properties, which can be enhanced through loading with biologics. "
8.	Polylactic Acid-Polyglycolic Acid CopolymerIBA 01/01/2015 - "Treating Proximal Tibial Growth Plate Injuries Using Poly(Lactic-co-Glycolic Acid) Scaffolds." 12/01/2015 - "The goal of this research was to develop an in vivo tissue-engineering approach for the treatment of growth plate injury via localized delivery of insulin-like growth factor I (IGF-I) from cell-free poly(lactic-co-glycolic acid) (PLGA) scaffolds. "
9.	Bevacizumab (Avastin)FDA Link 04/01/2014 - "Using a rat tibial growth plate injury repair model with anti-VEGF antibody, Bevacizumab, as a single i.p. " 01/01/2023 - "Conclusion: This bilayer microsphere-based composite hydrogel with sequential controlled release of Bevacizumab and IGF-1 has promising potential for growth plate injury repair."
10.	Matrilin ProteinsIBA 04/01/2022 - "Following growth plate injury, the direct loss of extracellular matrix (ECM) coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration. "

Therapies and Procedures

1.	Transplantation 01/01/2017 - "Costal cartilage transplantation for treatment of growth plate injury in a rabbit model." 07/01/2007 - "Transplantation of tissue engineered cartilage and chondrocytes might be a choice for repair of growth plate injury. " 01/01/2017 - "Transplantation of costal cartilage improved angular deformities and decreased bony bridge formation in the partial growth plate injury. " 01/01/2017 - "The purpose of this study is to evaluate the effects of allogenic costal cartilage transplantation on preventing bony bridge formation and angular deformities for the treatment of partial growth plate injury using a rabbit model. " 03/01/2016 - "In this study, CTA transplantation minimized deformity in the rabbit growth plate injury model, probably via the attenuation of bone bridge formation."
2.	Therapeutics 01/01/2023 - "Discussion: Accordingly, our study demonstrates the feasibility of using 3D printed scaffolds for treating growth plate injuries and could offer a new strategy for the development of growth plate tissue engineering therapy." 02/08/2023 - "Accordingly, GMOCS/BMSC therapy can be engineered as a promising therapeutic candidate for growth plate injury." 01/01/2017 - "In particular, the changes in proliferative and hypertrophic zone heights seen following injury may impact growth and could be targeted when developing therapies for growth plate injury." 01/01/2016 - "We would suggest that the high prevalence of growth plate fracture in the rabbit may represent a potential additional adverse risk to those already established for children treated with antiangiogenic therapy." 08/01/2014 - "Recent research on the growth plate: Mechanisms for growth plate injury repair and potential cell-based therapies for regeneration."
3.	Conservative Treatment 01/01/2005 - "The purpose of this study was to compare the results of Rush pin fixation with those of conservative treatment, and to evaluate the sequels of growth plate injury by internal fixation. "
4.	Phototherapy (Light Therapy) 08/01/2007 - "We demonstrated previously that receiving long-term phototherapy was associated with early impairment of growth plate structure in neonatal rats, and oxidative stress may be the main risk factor for growth plate injury. " 01/01/2006 - "These results suggest that in newborn rats, receiving phototherapy is associated with early impairment of growth plate structure, and oxidative stress may be the main risk factor for growth plate injury."
5.	Injections 01/01/2023 - "Injectable hydrogel loaded with bilayer microspheres to inhibit angiogenesis and promote cartilage regeneration for repairing growth plate injury." 01/01/2022 - "Results indicate that hydrogel composition and material properties affect the differentiation tendency of MSCs in vitro, and the PEC hydrogels show promise as an injectable biomaterial for growth plate injuries."