Myocardial Contusions

Bruise to the heart muscle due to blunt thoracic trauma.

Also Known As:

Blunt Cardiac Injury; Cardiac Contusion; Contusio Cordis; Heart Contusions; Myocardial Contusion; Blunt Cardiac Injuries; Cardiac Contusions; Cardiac Injuries, Blunt; Cardiac Injury, Blunt; Contusion, Cardiac; Contusion, Heart; Contusion, Myocardial; Contusions, Cardiac; Contusions, Heart; Contusions, Myocardial; Cordis, Contusio; Heart Contusion; Injuries, Blunt Cardiac; Injury, Blunt Cardiac

Networked: 209 relevant articles (6 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Wounds and Injuries: 176426
- Thoracic Injuries: 736
  - Heart Injuries: 645
    - Myocardial Contusions: 209
      - Commotio Cordis: 38
- Nonpenetrating Wounds: 315
  - Contusions: 2776
    - Myocardial Contusions: 209
      - Commotio Cordis: 38

Related Diseases

1.	Wounds and Injuries (Trauma)
2.	Aortic Rupture
3.	Abdominal Injuries
4.	Hypotension (Low Blood Pressure)
5.	Hypertension (High Blood Pressure)

Experts

1.	Ismailov, Rovshan M: 3 articles (06/2010 - 09/2005)
2.	Ieki, Yohei: 2 articles (10/2021 - 01/2017)
3.	Du, Ding-Yuan: 2 articles (04/2020 - 01/2020)
4.	Gao, Jin-Mou: 2 articles (04/2020 - 01/2020)
5.	Kong, Ling-Wen: 2 articles (04/2020 - 01/2020)
6.	Li, Chang-Hua: 2 articles (04/2020 - 01/2020)
7.	Li, Hui: 2 articles (04/2020 - 01/2020)
8.	Liu, Chao-Pu: 2 articles (04/2020 - 01/2020)
9.	Wei, Gong-Bin: 2 articles (04/2020 - 01/2020)
10.	Yang, Jun: 2 articles (04/2020 - 01/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myocardial Contusions:

1.	Troponin IIBA 02/01/1996 - "Improved detection of cardiac contusion with cardiac troponin I." 09/01/2022 - "The highest troponin I level during admission is associated with mortality in blunt cardiac injury patients." 12/01/2004 - "Sensitivity, specificity, and positive and negative predictive values of troponin I for the diagnosis of myocardial contusion were 63, 98, 40, and 98%, respectively. " 01/01/2003 - "Normal electrocardiography and serum troponin I levels preclude the presence of clinically significant blunt cardiac injury." 09/01/2000 - "Cardiac troponin I and myocardial contusion in the rabbit."
2.	trans-crotonin (CTN)IBA 05/01/2000 - "Although improved specificity of cTn-I and cTn-T compared with conventional markers, it should be emphasized that the main problem with cTn-I and cTn-T is low sensitivity as well as low predictive values in diagnosing myocardial contusion. " 05/01/2000 - "cTn-I and cTn-T measurement is currently not an improved method in diagnosing blunt cardiac injury in hemodynamically stable patients. " 05/01/2000 - "The percentage of patients with elevated circulating cTn-I and cTn-T (> or = 0.1 microg/L) was significantly higher in patients with myocardial contusion (23% vs. 3%; p = 0.01 and 12% vs. 0%; p = 0.03, respectively). " 05/01/2000 - "Sensitivity, specificity, and negative and positive predictive values of cTn-I and cTn-T in predicting a myocardial contusion in blunt trauma patients were 23%, 97%, and 77%, 75%, and 12%, 100%, and 74%, 100%, respectively. " 05/01/2023 - "One hundred thirty-five patients were evaluated for cardiac ischemia based on elevated cTn. In 91 (66.4%) cases, the elevated cTn was attributed to a cardiac oxygen supply/demand mismatch. The etiology was cardiac contusion for 26 (19.0%), with the rest attributed to various other trauma-related causes. The cardiology consult changed management for 90 (65.7%) patients, mainly consisting of further evaluation by echocardiogram for 78 (57.0%) patients. Elevated cTn was a significant independent predictor of death with an adjusted odds ratio of 2.6 (p=0.002). "
3.	Methylprednisolone FDA LinkGeneric 09/01/2014 - "We conclude that a combination of quercetin and methylprednisolone can be used for the specific treatment of cardiac contusion." 09/01/2014 - "A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats." 09/01/2014 - "The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. " 01/01/2014 - "Thirty-five female Wistar albino rats were randomly assigned to five groups (n = 7) including: sham controls (S); only cardiac contusion (CONT); cardiac contusion treated with methylprednisolone (CONT+MP); cardiac contusion treated with aminoguanidine (CONT+AG); and cardiac contusion treated with methylprednisolone and aminoguanidine (CONT+MP+AG). " 09/01/2014 - "Thirty-five female Sprague-Dawley rats were divided into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg·kg(-1)·day(-1)), and treated with a combination of methylprednisolone and quercetin. "
4.	QuercetinIBA 09/01/2014 - "We conclude that a combination of quercetin and methylprednisolone can be used for the specific treatment of cardiac contusion." 09/01/2014 - "A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats." 09/01/2014 - "The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. " 09/01/2014 - "Thirty-five female Sprague-Dawley rats were divided into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg·kg(-1)·day(-1)), and treated with a combination of methylprednisolone and quercetin. "
5.	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/01/2005 - "Nitric oxide inhalation is useful in the management of right ventricular failure caused by myocardial contusion."
6.	NitratesIBA 07/01/1994 - "[An evaluation of the efficacy of nitrates (transdermal and peroral) in the management of the patient with a myocardial contusion]." 07/01/1994 - "In order to compare safety and efficacy between two nitrates and placebo on myocardial contusion resulting from thoracic trauma, we carried out a comparative, prospective, single blind study. "
7.	2- benzylidene- 3- (cyclohexylamino)- 2,3- dihydro- 1H- inden- 1- oneIBA 01/01/2023 - "Our study aims to identify predictors of concomitant cardiac contusion among BTI patients and the predictors of mortality among patients presenting with BCI on a national level. " 05/01/2017 - "The aim of this study was to evaluate the incidence and severity of blunt cardiac injury (BCI) as determined by cardiac magnetic resonance imaging (CMR), and to compare this to currently used diagnostic methods in severely injured patients. " 01/01/1996 - "The goal of this study was to describe the epidemiology, clinical presentation, diagnostic methods, and outcome in a large series of children with blunt cardiac injury (BCI). " 10/01/2023 - "Blunt cardiac injury (BCI) has a variety of symptoms that may be a potentially life-threatening injury that can lead to death. " 05/09/2023 - "Unlike adults, less is known of the etiology and risk factors for blunt cardiac injury (BCI) in children. "
8.	IsoenzymesIBA 08/01/1993 - "Cardiac isoenzyme patterns were consistent with myocardial contusion in 18 patients (12%). " 08/01/1993 - "From July 1988 to July 1990, 159 consecutive cases of major blunt chest injury were evaluated prospectively for myocardial contusion with serial electrocardiographic monitoring, cardiac isoenzyme studies, and two-dimensional echocardiography. " 05/01/1983 - "All patients had multiple blunt injuries with cardiac contusion documented electrocardiographically, by CPK isoenzyme determinations, and clinically. " 09/01/2001 - "Many studies advocate creatine-kinase-MB (CK-MB) isoenzyme levels as a sensitive test for cardiac contusion. " 05/01/1987 - "Surface ECG in conjunction with creatinine phosphokinase (CPK) isoenzyme assay, has been an accepted standard for diagnosis of posttraumatic cardiac dysfunction, or "cardiac contusion." Studies employing recently developed noninvasive cardiac imaging techniques have called this practice into question and have shed new light on the pathophysiology of this clinical entity. "
9.	EnzymesIBA 05/01/2000 - "A review of the management of isolated sternal fractures in a regional cardiothoracic unit reveals that, in a 2 year period, 37 consecutive patients were admitted for observation and further investigation, including echocardiography and cardiac enzyme measurements to exclude blunt cardiac injury. " 01/01/2000 - "Criteria of heart contusion diagnosis by electrocardiography, integral body rheography, ultrasonic diagnosis, heart enzymes analysis were covered. " 12/01/1994 - "Cardiac enzyme determinations have no useful role in the evaluation of patients with suspected myocardial contusion. " 12/01/1994 - "Cardiac enzymes are irrelevant in the patient with suspected myocardial contusion." 11/01/1994 - "Neither clinical findings, cardiac enzymes values, serial ECG's nor TTE predicted all the patients who had traumatic cardiac injury and those would subsequently developed complications related to cardiac contusion. "
10.	MB Form Creatine KinaseIBA 09/01/2001 - "On the other hand, a myocardial contusion was shown by ECHO examination only while echocardiogram and creatine kinase MB tests remained normal in that patient. " 04/01/1994 - "Cardiac contusion and creatine kinase-MB: a pertinent case history and brief review of the utility of CK-MB." 12/01/1990 - "A diagnosis of a myocardial contusion was made if patients had an ECG consistent with acute injury, increased creatine kinase-MB, or an abnormal echocardiogram consistent with acute injury. " 11/01/1989 - "Myocardial contusion without creatine kinase--MB elevation." 01/01/1985 - "Creatine kinase MB and M-mode echocardiographic changes in cardiac contusion."

Therapies and Procedures

1.	Chest Tubes (Chest Tube) 08/01/1987 - "The following occurred with significantly greater frequency in patients with thoracic aortic rupture than in those without: history of significant hypotension (mean arterial pressure less than 80 mm Hg) (p less than 0.04); the presence of upper extremity hypertension, bilateral lower extremity pulse pulse deficits, or an initial chest tube output greater than 750 ml of blood (p less than 0.05); and greater incidence of myocardial contusions, intra-abdominal injuries, and pelvic fractures compared with patients without thoracic aortic rupture (p less than 0.05). " 01/01/2023 - "The secondary outcomes were the association of age and sex, concomitant head injury, lung and cardiac contusions, the onset of mechanical ventilation (MV) and chest tubes insertion, the length of mechanical ventilation and ICU stay in days, injury severity score (ISS), associated surgeries, pneumonia, sepsis, the implication of standard fluid therapy and steroid therapy, and the systemic and regional analgesia, with the overall mortality rates. "
2.	Cardiac Catheters 06/01/2002 - "To study changes and rules of the left ventricular functions in rabbits with myocardial contusion through parallel functional analysis by using echocardiography combined with cardiac catheter intervention. "
3.	Therapeutics 11/01/2022 - "This evidence-based review aims to provide an overview of the topic by focusing on etiopathogenesis, classification and clinical presentation of patients with cardiac contusions, as well as on the diagnostic work-up and therapy options available for this subset population in the acute care setting. " 01/01/1999 - "Of the total number of injured persons in 150 with heart contusion (basic group) the cardiotropic therapy conduction was started from the hospitalization moment and in 134 (control group)--from the second day and later. " 01/01/1998 - "A rational program of intensive therapy for heart contusions is proposed aimed at the maintenance and development of compensatory abilities in the hemodynamic system. " 09/01/1995 - "No patient developed any complications of myocardial contusion requiring therapy. " 03/01/1988 - "[Clinical picture, diagnosis and combined therapy of cardiac contusions]."
4.	Counterpulsation (External Counterpulsation) 12/01/1990 - "This report describes the successful application of intra-aortic balloon counterpulsation in a critically injured patient requiring emergent repair of a thoracic aortic tear complicated by ventricular failure due to cardiac contusion." 05/01/1983 - "Intra-aortic balloon counterpulsation in blunt cardiac injury." 10/01/1978 - "Myocardial contusion: effect of intra-aortic balloon counterpulsation on cardiac output." 12/01/2002 - "The use of intra-aortic balloon counterpulsation (IABCP) as a mechanical means of augmenting cardiac function following cardiac contusion is rare with case reports largely limited to its use in young trauma patients. " 11/01/1987 - "A case of successful management of a patient with post-traumatic myocardial contusion complicated by refractory cardiogenic shock using intra-aortic balloon pump counterpulsation is presented. "
5.	Length of Stay 06/01/2008 - "There is worsened morbidity with a 2-fold increase in ICU LOS and hospital stay, and a 1.5-fold increase in mortality in the severe myocardial contusion group. " 05/01/2000 - "Patients with myocardial contusion had a significantly higher Injury Severity Score at the time of admission (p = 0.001) and a significantly longer hospital stay (p = 0.0008). " 02/01/2022 - "Hemothorax, displaced SF and decreased MuA were predictors of prolonged hospital stay, and the presence of cardiac contusion, displaced SF, hemothorax, and vertebra body fracture were independent factors for death. " 01/01/2020 - "Blunt cardiac injuries after trauma are associated with a longer hospital stay and a poor overall outcome. " 06/01/2008 - "They presented with moderate to severe trauma acuity defined as mean GCS of 8.6, TS of 11.3, and ISS of 34 with an increased mean hospital stay of 15 days versus 6 days in the ICU; and a 26 days versus 10 days overall stay for those with myocardial contusion (p < 0.05). "