Tumor Suppressor p53-Binding Protein 1

A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.

Also Known As:

Networked: 22 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Choubey, Divaker: 4 articles (01/2017 - 05/2006)
2.	Pawlowska, Elzbieta: 2 articles (05/2020 - 07/2019)
3.	Panchanathan, Ravichandran: 2 articles (01/2017 - 10/2014)
4.	Swisher, Elizabeth M: 2 articles (10/2013 - 03/2013)
5.	Wickramanayake, Anneka: 2 articles (10/2013 - 03/2013)
6.	Arimura-Omori, Masako: 1 article (04/2021)
7.	Furuie, Hironobu: 1 article (04/2021)
8.	Hamada, Naoki: 1 article (04/2021)
9.	Kiyohara, Chikako: 1 article (04/2021)
10.	Yanagihara, Toyoshi: 1 article (04/2021)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "Phospho-ATM and 53BP1 protein expressions were determined in human breast cancer tissues by immunohistochemistry (IHC). " 03/01/2013 - "BRCA1-mutated ovarian carcinomas have higher 53BP1 protein expression than wildtype or BRCA2-mutated carcinomas, in opposition to previous findings in breast carcinomas. " 07/01/2014 - "We review novel and exciting crosstalk mechanisms between ubiquitination and other post-translational modifications, many of which work synergistically with each other to activate signaling events and help recruit important DNA damage effector proteins, particularly BRCA1 (breast cancer 1, early onset) and 53BP1 (tumor protein p53 binding protein 1), to sites of DNA damage. " 11/05/2013 - "BRCA1 promoter hypermethylation, 53BP1 protein expression and PARP-1 activity as biomarkers of DNA repair deficit in breast cancer." 05/23/2020 - "In a fraction of TNBCs that harbor mutations that cause the loss of function of the DNA repair-associated breast cancer type 1 susceptibility (BRCA1) gene, 1,25(OH)2D may induce protective effects by activating its receptor and inactivating cathepsin L-mediated degradation of tumor protein P53 binding protein 1 (TP53BP1), preventing deficiency in DNA double-strand break repair and contributing to genome stability. "
2.	Genomic Instability 05/23/2020 - "In a fraction of TNBCs that harbor mutations that cause the loss of function of the DNA repair-associated breast cancer type 1 susceptibility (BRCA1) gene, 1,25(OH)2D may induce protective effects by activating its receptor and inactivating cathepsin L-mediated degradation of tumor protein P53 binding protein 1 (TP53BP1), preventing deficiency in DNA double-strand break repair and contributing to genome stability. "
3.	Neoplasms (Cancer) 04/01/2021 - "The tumor suppressor p53 (TP53), which has been shown to interact with tumor protein p53-binding protein 1 (TP53BP1), is implicated in the response to telomere shortening and aging.  Polymorphisms in the TP53 and TP53BP1 genes are associated with various types of cancer. " 01/01/2017 - "PAXIP1 and 53BP1 protein levels followed gene expression results, i.e., are intrinsically correlated, and also reduced in more advanced tumors. " 11/05/2013 - "Breast cancers that harbour simultaneously high 53BP1 protein level and BRCA1 promoter hypermethylation and are the putative target population of drugs targeting DNA repair appear to be restricted to a small subgroup of TN tumours." 09/06/2010 - "In this review we discuss how increased levels of the p202 protein (and its human functional homologue IFI16 protein) in B cells increase lupus susceptibility and are likely to increase the risk of developing certain B cell malignancies. " 01/01/2014 - "The study investigated several common SNPs in the tumor protein p53 binding protein 1 gene and tumor protein p53 gene in 640 lung cancer cases and 685 controls in Han Chinese to determine if these single nucleotide polymorphisms (SNPs) were associated with lung cancer risk. "
4.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "The study investigated several common SNPs in the tumor protein p53 binding protein 1 gene and tumor protein p53 gene in 640 lung cancer cases and 685 controls in Han Chinese to determine if these single nucleotide polymorphisms (SNPs) were associated with lung cancer risk. "
5.	Carcinoma (Carcinomatosis) 03/01/2013 - "BRCA1-mutated (but not BRCA2-mutated) ovarian carcinomas had significantly higher 53BP1 protein expression than wildtype carcinomas. " 03/01/2013 - "Higher 53BP1 protein, which promotes NHEJ, could explain the frequent chromosomal aberrations that are characteristic of BRCA1-mutated ovarian carcinomas. " 03/01/2013 - "BRCA1-mutated ovarian carcinomas have higher 53BP1 protein expression than wildtype or BRCA2-mutated carcinomas, in opposition to previous findings in breast carcinomas. " 10/15/2013 - "Finally, concomitant increased mutant BRCA1 and decreased 53BP1 protein expression occur in clinical samples of BRCA1-mutated recurrent ovarian carcinomas that have developed resistance to platinum. " 09/01/2007 - "In 3 human esophageal carcinoma cell lines, TE-1, TE-13 and Eca109 cells, the expressions of MDC1 and 53BP1 mRNA were detected with RT-PCR, and MDC1 and 53BP1 protein expressions were measured with immunohistochemistry, indirect immunofluorescence and Western blotting, respectively. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	Cathepsin L
3.	hydroxide ion
4.	Proteins (Proteins, Gene)
5.	Histones (Histone)
6.	Messenger RNA (mRNA)
7.	Ubiquitin-Specific Proteases
8.	Lysosomal-Associated Membrane Protein 2
9.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
10.	Ubiquitin