Regulatory Factor X1

A regulatory factor X transcription factor that is required for the expression of MHC CLASS II GENES. It also binds to inverted repeats of HEPATITIS B VIRUS DNA and is required for viral gene expression. RFX1 functions as a monomer or heterodimer with other RFX transcription factors.

Also Known As:

MHC Class II Regulatory Factor RFX; RF-X Binding Protein; RFX Regulatory Factor; RFX1 Protein; RFX1 Transcription Factor; Regulatory Factor X; Regulatory Factor-X; X Box Binding Protein (RF-X); RF X Binding Protein; Regulatory Factor, RFX; Transcription Factor, RFX1

Networked: 21 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Winged-Helix Transcription Factors: 6
      - Regulatory Factor X Transcription Factors: 3
        Regulatory Factor X1: 21
        human RFX1 protein
        mouse Rfx1 protein
        rat Rfx1 protein
  - DNA-Binding Proteins: 2009
    - Winged-Helix Transcription Factors: 6
      - Regulatory Factor X Transcription Factors: 3
        Regulatory Factor X1: 21
        human RFX1 protein
        mouse Rfx1 protein
        rat Rfx1 protein

Experts

1.	Zhao, Ming: 4 articles (01/2019 - 01/2010)
2.	Lu, Qianjin: 3 articles (01/2018 - 01/2010)
3.	Guo, Yu: 2 articles (01/2018 - 01/2016)
4.	Liang, Gongping: 2 articles (01/2018 - 01/2010)
5.	Tan, Yixin: 2 articles (01/2018 - 01/2010)
6.	Bernhart, Stephan H: 1 article (01/2021)
7.	Coronel, Luis: 1 article (01/2021)
8.	Fischer, Martin: 1 article (01/2021)
9.	Förste, Silke: 1 article (01/2021)
10.	Hoffmann, Steve: 1 article (01/2021)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/2018 - "Previous studies have demonstrated that pancreatic cancer-derived microRNA (miR)-212-3p can inhibit the expression of regulatory factor X-associated protein (RFXAP), an important transcription factor for major histocompatibility complex (MHC) class II, and thereby lead to downregulation of MHC class II in dendritic cells. "
2.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 06/01/2000 - "Mutations in the bare lymphocyte syndrome define critical steps in the assembly of the regulatory factor X complex." 12/15/1999 - "MHC class II deficiency found in bare lymphocyte syndrome patients results from the absence or dysfunction of MHC class II transcriptional regulators, such as regulatory factor X (RFX) and class II transactivator (CIITA). " 05/09/2008 - "After purification to near homogeneity, the stimulatory factor is associated with three polypeptides with apparent molecular masses of 68, 36, and 30 kDa. Peptide sequencing analysis by tandem mass spectrometry identified the stimulatory factor as the heterotrimeric regulatory factor X (RFX) complex, which regulates transcription of the class II major histocompatibility complex by facilitating histone acetylation and is defective in the human hereditary immunodeficiency syndrome called bare lymphocyte syndrome. " 06/15/1997 - "Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex."
3.	Neoplasms (Cancer) 01/01/2021 - "Recently, the regulatory factor X 7 (RFX7) emerged as a suppressor of lymphoid neoplasms, but its regulation and target genes mediating tumor suppression remain unknown. " 01/01/2020 - "Alterations in the Regulatory factor X 7 (RFX7) gene have recurrently been reported in lymphoid cancers. " 01/01/2020 - "Regulatory Factor X 7 and its Potential Link to Lymphoid Cancers." 01/01/2018 - "Regulatory factor X1 (RFX1) deletion has been reported to be correlated with poor prognosis of some types of cancer. " 08/01/2014 - "Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma."
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/2016 - "Transcription factor RFX1 is ubiquitinated by E3 ligase STUB1 in systemic lupus erythematosus." 01/01/2018 - "Here we show reduced expression of the transcription factor RFX1 in CD4+ T cells from patients with systemic lupus erythematosus, which leads to IL-17A overexpression through increased histone H3 acetylation and decreased DNA methylation and H3K9 tri-methylation. " 01/01/2010 - "Regulatory factor X-box 1 (RFX1) can interact with DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1), and RFX1 down-regulation contributes to DNA hypomethylation and histone H3 hyperacetylation at the cluster of differentiation (CD) 11a and CD70 promoters in CD4(+) T cells of patients with systemic lupus erythematosus (SLE). "
5.	Glioblastoma (Glioblastoma Multiforme) 11/28/2016 - "After transfection of pITA-RFX1, the RFX1 protein were over-expressed, which significantly inhibited the proliferation of F98 cells.  Conclusion: The overexpression lentivirus vector for RFX1 was constrcted successfully, and the up-regulation of RFX1 can prevent the proliferation of glioblastoma cells. " 08/01/2014 - "Regulatory factor X1 bound to the CD44 gene in glioblastoma cells. " 08/01/2014 - "Regulatory factor X1 was overexpressed in 4 human glioblastoma cell lines. " 08/01/2014 - "Finally, CD44 protein levels were inversely correlated with RFX1 protein levels in human glioblastoma tissues. " 08/01/2014 - "Regulatory factor X1 is a new tumor suppressive transcription factor that acts via direct downregulation of CD44 in glioblastoma."

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Proteins (Proteins, Gene)
3.	MicroRNAs (MicroRNA)
4.	Histones (Histone)
5.	Regulatory Factor X Transcription Factors
6.	MHC class II transactivator protein
7.	Histone Deacetylase 1
8.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
9.	Interleukin-17 (Interleukin 17)
10.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)