Histidine Kinase

A member of the transferase superfamily of proteins. In the activated state, protein-histidine kinase autophosphorylates at a histidine residue, subsequently transferring high-energy phosphoryl groups to an aspartate residue of the response-regulator domain, which results in a conformational shift in the effector domain. Histidine kinases mediate signal transduction in a wide range of processes involving cellular adaptation to environmental stress.

Also Known As:

Histidine Protein Kinase; Histone H4 Histidine Kinase; Protein Histidine Pros-Kinase; Protein Kinase (Histidine), Pros-Kinase; Protein-Histidine Kinase; Protein-Histidine Pros-Kinase; Protein-Histidine Tele-Kinase; Sensor Histidine Kinase; Histidine Kinase, Sensor; Histidine Pros-Kinase, Protein; Kinase, Histidine; Kinase, Histidine Protein; Kinase, Protein-Histidine; Kinase, Sensor Histidine; Pros-Kinase, Protein Histidine; Pros-Kinase, Protein-Histidine; Protein Histidine Kinase; Protein Histidine Pros Kinase; Protein Histidine Tele Kinase; Protein Kinase, Histidine; Tele-Kinase, Protein-Histidine

Networked: 94 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fillinger, Sabine: 4 articles (10/2020 - 07/2008)
2.	Steeg, Patricia S: 4 articles (02/2018 - 08/2002)
3.	Kaetzel, David M: 3 articles (01/2011 - 08/2006)
4.	Yang, Mengmeng: 3 articles (01/2011 - 08/2006)
5.	Qu, Di: 2 articles (03/2012 - 11/2006)
6.	Wu, Yang: 2 articles (03/2012 - 11/2006)
7.	Attwood, Paul V: 2 articles (02/2012 - 11/2004)
8.	Besant, Paul G: 2 articles (02/2012 - 11/2004)
9.	Leroux, Pierre: 2 articles (01/2012 - 07/2008)
10.	Eswaramoorthy, Prahathees: 2 articles (11/2011 - 08/2010)

Related Diseases

1.	Infections 09/01/2023 - "LytS/LytTR-type histidine kinase/response regulator systems regulate crucial host-specific mechanisms during infection of human or plant hosts. " 05/17/2023 - "Targeting multidrug resistant Staphylococcus infections with bacterial histidine kinase inhibitors." 01/01/2023 - "We found that factors associated with the type IV pilus, including the histidine kinase subunit of a chemotactic two-component signaling system (chpA), had increased transcript levels during dual-species infection. " 01/01/2020 - "Previously it was shown that the cognate histidine kinase HK2 is not required for Rrp2 activation in vitro, nor for mammalian infection upon needle inoculation, raising the question whether HK2 has any role in the enzootic cycle of B. " 10/01/2017 - "Furthermore, we evaluated Arabidopsis histidine kinase receptor mutant lines ahk2/3, ahk2/4 and ahk3/4 in response to RKN infection. "
2.	Branchiootic syndrome 04/01/2014 - "Sequence analysis of the target gene bos1, which codes for a class III histidine kinase, revealed that the MR phenotype was associated with Q369P and N373S mutations and that the LR phenotype was associated with either a I365S or a I365N mutation. " 05/01/2010 - "In the present study, the complete two-component histidine kinase gene (Bos1) was sequenced for 10 procymidone-resistant and 3 procymidone-sensitive B. " 01/04/2023 - "Based on RNA-sequence analysis, it was found that hybrid histidine kinase, fungal HHKs, such as BOS1, BcHHK2, and BcHHK17, probably involved in the fludioxonil resistance of B. " 10/01/2020 - "We studied the mutants of the sensor histidine kinase Bos1 and of the MAP kinase Sak1. " 01/01/2018 - "Since one or several allelic mutations in the histidine kinase (Bos1) and β-tubulin genes generally confer the resistance to fungicides, the sequences of these target genes were investigated in the selected isolates, which allowed the identification of two different haplotypes. "
3.	Mastitis 09/26/2023 - "Our results suggest that the selected natural compounds have the potential to serve as effective inhibitors of transmembrane histidine kinase and can be utilized for the development of novel antibacterial veterinary medicine for mastitis after further validation through clinical studies." 09/26/2023 - "Identification of histidine kinase inhibitors through screening of natural compounds to combat mastitis caused by Streptococcus agalactiae in dairy cattle."
4.	Neoplasm Metastasis (Metastasis) 02/01/2003 - "We hypothesize that a histidine protein kinase activity of Nm23 underlies its suppression of metastasis, and identify candidate substrates. " 08/30/2002 - "The metastasis-suppressive activity of Nm23-H1 was previously correlated with its in vitro histidine protein kinase activity, but physiological substrates have not been identified. " 01/01/2014 - "NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity. " 08/30/2002 - "Nm23-H1 metastasis suppressor phosphorylation of kinase suppressor of Ras via a histidine protein kinase pathway." 01/01/2011 - "Although the histidine kinase has been implicated in suppression of motility in breast carcinoma cell lines, potential relevance of the NDPK and 3'-5' exonuclease to metastasis suppressor function has not been addressed in detail. "
5.	Starvation 11/01/2011 - "It is believed that the N-terminal sensor domain of the cytoplasmic histidine kinase KinA is responsible for detection of the sporulation-specific signal(s) that appears to be produced only under starvation conditions. " 01/01/2019 - "The typical two-component regulatory systems (TCSs), consisting of response regulator and histidine kinase, play a central role in survival of pathogenic bacteria under stress conditions such as nutrient starvation, hypoxia, and nitrosative stress. " 08/01/2010 - "Upon nutrient starvation, the Gram-positive bacterium Bacillus subtilis switches from growth to sporulation by activating a multicomponent phosphorelay consisting of a major sensor histidine kinase (KinA), two phosphotransferases (Spo0F and Spo0B) and a response regulator (Spo0A). " 12/01/1997 - "This gene is predicted to encode a sensor histidine protein kinase that appears to be a key element in the transduction of starvation and cell density inputs. " 08/01/1990 - "PhoR protein is a histidine protein kinase, induced in Pi starvation and is a transmembrane protein. "

Related Drugs and Biologics

1.	procymidone
2.	homocysteine-thiolactone-nicotinamide (ST 22)
3.	Proteins (Proteins, Gene)
4.	Phosphotransferases (Kinase)
5.	Nucleoside-Diphosphate Kinase
6.	Histidine (L-Histidine)
7.	Phosphoric Monoester Hydrolases (Phosphatases)
8.	Pheromones (Semiochemicals)
9.	Exonucleases (3' 5' Exonuclease)
10.	Enzymes