Sequestosome-1 Protein

A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alafuzoff, Irina: 3 articles (12/2011 - 04/2008)
2.	Hartikainen, Päivi: 3 articles (12/2011 - 04/2008)
3.	Pikkarainen, Maria: 3 articles (12/2011 - 04/2008)
4.	Decheng, Bai: 1 article (01/2022)
5.	Lixia, Zhao: 1 article (01/2022)
6.	Wei, Sun: 1 article (01/2022)
7.	Duan, Ning: 1 article (06/2018)
8.	Hu, Bin: 1 article (06/2018)
9.	Li, Ming: 1 article (06/2018)
10.	Li, Zhong: 1 article (06/2018)

Related Diseases

1.	Motor Neuron Disease (Primary Lateral Sclerosis) 01/09/2009 - "In this study, we examined the extent of motor neuron disease-related changes in the brain of 9 subjects using ubiquitin-binding protein p62/sequestosome 1 (p62) immunohistochemistry. " 01/09/2009 - "Expression of collagen XVII and ubiquitin-binding protein p62 in motor neuron disease."
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/01/2006 - "Immunoreactivity of ubiquitin-binding protein p62 has been reported in various neurodegenerative diseases, but it has not been studied in NFID. " 11/01/2006 - "An ubiquitin-binding protein, p62, is one of the components of the ubiquitin-containing inclusions in several human neurodegenerative diseases. " 11/01/2009 - "The p62/sequestosome 1 protein has been identified as a component of pathological protein inclusions in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). "
3.	Neoplasms (Cancer) 12/15/2016 - "The ubiquitin-binding protein p62/Sqstm1 (p62), which is highly expressed in several cancers, competes with Nrf2 for Keap1 binding, leading to activation of Nrf2-mediated gene expression and survival of cancer cells. " 03/01/2007 - "The ubiquitin-binding protein p62 is expressed in breast cancers showing features of aggressive disease." 06/01/2018 - "p62 (also known as sequestosome 1) protein, is a small regulatory protein that accumulates in autophagy-defective cells that has been demonstrated to be involved in the prognosis and survival of patients with several types of cancer. "
4.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2023 - "The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer." 07/01/2011 - "Here, we show a critical role for the ubiquitin-binding protein p62/SQSTM1 in cisplatin resistance in human ovarian cancer cells (HOCCs). "
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 04/01/2004 - "Expression of ubiquitin-binding protein p62 in ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrum." 11/01/2009 - "The p62/sequestosome 1 protein has been identified as a component of pathological protein inclusions in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). "

Related Drugs and Biologics

1.	Ubiquitin
2.	Proteins (Proteins, Gene)
3.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
4.	Presenilins
5.	alpha-Synuclein
6.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Messenger RNA (mRNA)
9.	Phosphotransferases (Kinase)
10.	Phosphoric Monoester Hydrolases (Phosphatases)