Autophagy-Related Protein 12

A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization to vesicle membranes.

Also Known As:

ATG12 Protein; Ubiquitin-Like Protein ATG12; ATG12, Ubiquitin-Like Protein; Autophagy Related Protein 12; Ubiquitin Like Protein ATG12

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Autophagy-Related Proteins: 555
    - Autophagy-Related Protein 12: 4
  - Ubiquitins: 125
    - Autophagy-Related Protein 12: 4

Experts

1.	Ademi, Hyrijie: 1 article (01/2020)
2.	Bovet, Cédric: 1 article (01/2020)
3.	Djonov, Valentin: 1 article (01/2020)
4.	Felser, Andrea: 1 article (01/2020)
5.	Fiedler, Martin: 1 article (01/2020)
6.	Frangež, Živa: 1 article (01/2020)
7.	Germič, Nina: 1 article (01/2020)
8.	He, Zhaoyue: 1 article (01/2020)
9.	Liu, He: 1 article (01/2020)
10.	Mlinarič-Raščan, Irena: 1 article (01/2020)

Related Diseases

1.	Tuberous Sclerosis (Bourneville's Disease) 12/20/2017 - "RK also reduced the expression of light chain 3B (LC3B), autophagy-related protein 12 (Atg12), sirtuin 1 (SIRT1), and phosphorylated-tuberous sclerosis complex 2 (TSC2), whereas it increased the level of p62 and phosphorylated-mammalian target of rapamycin (mTOR). " 01/01/2018 - "Indicators of autophagy [expression of beclin 1, autophagy-related protein 12 (Atg 12), unc-51 like autophagy activating kinase 1 (Ulk 1), p62 and lysosome-associated membrane protein 2 (LAMP 2) and conversion of microtubule-associated protein 1A/1B-light chain 3 (LC3) I to II], signalling cascade [phosphorylated (p) 5' adenosine monophosphate-activated protein kinase (p-AMPK), sirtuin 1 (Sirt 1), phosphorylated-mammalian target of rapamycin (p-mTOR), tuberous sclerosis complex 2 (TSC 2), p317Ulk 1 and p757Ulk 1 levels] and lysosome morphology were assessed in control and cypermethrin-treated rat model of PD. "
2.	Neoplasms (Cancer) 01/01/2020 - "Here, we report that cancer cells with reduced autophagy-related protein 12 (ATG12) expression undergo an oncotic cell death, a phenotype distinct from that seen in ATG5-deficient cells described before. "
3.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2018 - "MicroRNA-378 enhances migration and invasion in cervical cancer by directly targeting autophagy-related protein 12."

Related Drugs and Biologics

1.	TOR Serine-Threonine Kinases
2.	Sirtuin 1
3.	Lysosomal Membrane Proteins
4.	Sirtuins
5.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
6.	Adenosine Monophosphate (AMP)
7.	Autophagy-Related Protein-1 Homolog
8.	Beclin-1
9.	trans-sodium crocetinate (crocetin)
10.	protein kinase P