Trefoil Factor-2

A 106 amino acid (12 kDa) trefoil factor that contains two trefoil domains and associates with MUCIN-6. It is expressed in the GASTROINTESTINAL TRACT by cells of BRUNNER GLANDS; PYLORIC GLANDS and mucous neck cells. It inhibits GASTROINTESTINAL MOTILITY and GASTRIC ACID secretion and may help maintain the structural integrity of gastric mucus.

Also Known As:

Networked: 42 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Wang, Timothy C: 6 articles (12/2016 - 11/2006)
2.	Giraud, Andrew S: 3 articles (01/2013 - 12/2010)
3.	Fox, James G: 3 articles (03/2012 - 08/2009)
4.	Alvarado-Cabrero, Isabel: 2 articles (01/2022 - 01/2021)
5.	Hoang, Lien: 2 articles (01/2022 - 01/2021)
6.	Oliva, Esther: 2 articles (01/2022 - 01/2021)
7.	Park, Kay J: 2 articles (01/2022 - 01/2021)
8.	Pesci, Anna: 2 articles (01/2022 - 01/2021)
9.	Soslow, Robert A: 2 articles (01/2022 - 01/2021)
10.	Stolnicu, Simona: 2 articles (01/2022 - 01/2021)

Related Diseases

1.	Infections 09/15/2012 - "As mechanisms that restore epithelial barrier function following infection remain poorly understood, this study investigated the role of trefoil factor 2 (TFF2), a well-established regulator of mucosal tissue repair. " 01/01/2019 - "Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen Escherichia coli K1." 03/12/2012 - "In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. " 12/01/2010 - "Helicobacter pylori infection promotes methylation and silencing of trefoil factor 2, leading to gastric tumor development in mice and humans."
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2018 - "Pancreatic-cancer-cell-derived trefoil factor 2 impairs maturation and migration of human monocyte-derived dendritic cells in vitro." 01/01/2020 - "This study aimed to determine the role of trefoil factor 2 (TFF2) in the proliferation and apoptosis of LPS-induced normal pancreatic duct cells and pancreatic cancer cells through β-catenin pathway. " 01/01/2020 - "Trefoil Factor 2 Regulates Proliferation and Apoptosis of Pancreatic Cancer Cells and LPS-Induced Normal Pancreatic Duct Cells by β-Catenin Pathway." 06/01/2001 - "Two of these tags corresponded to genes (lipocalin and trefoil factor 2) previously shown to be overexpressed in pancreatic carcinoma, whereas the third tag corresponded to prostate stem cell antigen (PSCA), a recently discovered gene thought to be largely restricted to prostatic basal cells and prostatic adenocarcinomas. " 05/01/2015 - "A total of 18 proteins were identified as being more abundant in the malignant group (CCA and pancreatic cancer) than in the benign strictures group, including myeloperoxidase, complement C3, inter-alpha-trypsin inhibitor heavy chain H4, apolipoprotein B-100, and kininogen-1 isoform 2. A total of 30 proteins were identified to be less abundant in the malignant group than in the benign group, including trefoil factor 2, superoxide dismutase [Cu-Zn], kallikrein-1, carboxypeptidase B and trefoil factor 1. Protein biomarkers in bile may differentiate malignant from benign biliary strictures. "
3.	Lung Injury 03/12/2012 - "In this study, we demonstrate in mice that TFF2 (trefoil factor 2), an epithelial cell-derived repair molecule, is needed for the control of lung injury caused by the hookworm parasite Nippostrongylus brasiliensis and for type 2 immunity after infection. "
4.	Periodontitis 01/01/2023 - "The current study aims to determine the expression of trefoil factor 2 (TFF2), trefoil factor 3 (TFF3), and adrenomedullin (ADM) in salivary samples of periodontitis patients with and without coronary heart disease (CHD). "
5.	Coronary Disease (Coronary Heart Disease) 01/01/2023 - "Expression of trefoil factor 2 and 3 and adrenomedullin in chronic periodontitis subjects with coronary heart disease." 01/01/2023 - "The current study aims to determine the expression of trefoil factor 2 (TFF2), trefoil factor 3 (TFF3), and adrenomedullin (ADM) in salivary samples of periodontitis patients with and without coronary heart disease (CHD). "

Related Drugs and Biologics

1.	Trefoil Factor-3
2.	Adrenomedullin
3.	Catenins
4.	spasmolytic polypeptide
5.	Biomarkers (Surrogate Marker)
6.	Messenger RNA (mRNA)
7.	Mucins
8.	Allergens
9.	Trefoil Factor-1
10.	Trefoil Factors