Lysine Acetyltransferases

Acetyltransferases that can transfer an acyl group to specific LYSINE residues within HISTONES (HISTONE ACETYLTRANSFERASES) and/or non-histone proteins.

Also Known As:

K-Lysine Acetyltransferases; Acetyltransferase, K-Lysine; Acetyltransferase, Lysine; Acetyltransferases, K-Lysine; Acetyltransferases, Lysine; K Lysine Acetyltransferase; K Lysine Acetyltransferases; K-Lysine Acetyltransferase; Lysine Acetyltransferase

Networked: 125 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Acetyltransferases: 1040
        Lysine Acetyltransferases: 125
        Histone Acetyltransferases: 655
        mouse Kyat3 protein

Experts

1.	Yang, Xiang-Jiao: 4 articles (01/2020 - 01/2004)
2.	Sethi, Gautam: 3 articles (01/2021 - 12/2015)
3.	Shanmugam, Muthu K: 3 articles (01/2021 - 12/2015)
4.	Kundu, Tapas K: 3 articles (01/2017 - 12/2015)
5.	Chen, Rui: 3 articles (01/2015 - 08/2012)
6.	Garcia, Joseph A: 3 articles (01/2015 - 08/2012)
7.	Gerard, Robert D: 3 articles (01/2015 - 08/2012)
8.	Sullivan, William J: 3 articles (01/2015 - 04/2010)
9.	Xu, Min: 3 articles (01/2015 - 08/2012)
10.	Chen, Jie: 2 articles (07/2022 - 05/2013)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2023 - "These genes encode two highly evolutionarily conserved, ubiquitously expressed, and homologous lysine-acetyltransferases, that are involved in number of basic cellular activities, such as DNA repair, cell proliferation, growth, differentiation, apoptosis of cells, and tumor suppression. " 06/09/2023 - "Lysine acetyltransferases 2 A (KAT2A) is a succinyltransferase that plays an essential role in cancer development. " 01/01/2022 - "Lysine acetyltransferase 2B (KAT2B) plays a crucial role in the regulation of gene expression at the post-transcriptional level by acetylation, and is associated with many types of cancer. " 06/05/2020 - "Herein, we assessed the effect of CPTH6, a lysine acetyltransferase inhibitor and anti-tumoral compound, on angiogenesis-related properties of both endothelial and cancer cells. " 06/05/2020 - "Inhibition of lysine acetyltransferases impairs tumor angiogenesis acting on both endothelial and tumor cells."
2.	Neurodevelopmental Disorders 01/01/2023 - "Arboleda-Tham syndrome caused by pathogenic variants in KAT6A (Lysine Acetyltransferase 6A; OMIM 601408) has been recently described as a new neurodevelopmental disorder. " 05/28/2021 - "Rubinstein-Taybi syndrome (RSTS) is a rare neurodevelopmental disorder caused by mutations in CREBBP or EP300 genes encoding CBP/p300 lysine acetyltransferases. " 01/01/2014 - "We discuss here a neurodevelopmental disorder, the Rubinstein-Taybi syndrome (RSTS), originated by mutations in the genes encoding the lysine acetyltransferases CBP and p300. " 01/01/2017 - "In this review, we summarize the current basic knowledge on the specific roles of lysine acetyltransferase (KAT) and lysine deacetylase (KDAC) complexes in brain development and the different neurodevelopmental disorders that are associated with dysfunctional lysine (de)acetylation machineries." 01/01/2018 - "Rubinstein-Taybi syndrome (RSTS) is a rare neurodevelopmental disorder characterized by distinctive facial features, growth retardation, broad thumbs and toes and mild to severe intellectual disability, caused by heterozygous mutations in either CREBBP or EP300 genes, encoding the homologous CBP and p300 lysine-acetyltransferases and transcriptional coactivators. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2022 - "Lysine Acetyltransferases and Their Role in AR Signaling and Prostate Cancer." 01/01/2020 - "The lysine-acetyltransferase p300 has been correlated to prostate cancer (PCa) progression. " 01/01/2017 - "ING3 is a stoichiometric member of the TIP60 lysine acetyltransferase complex implicated in prostate cancer development. " 12/01/2021 - ": CMA: chaperone-mediated autophagy; HDAC2: histone deacetylase 2; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; KAT2B: lysine acetyltransferase 2B; LAMP2A: lysosomal associated membrane protein 2A; PCa: prostate cancer; TPD52: tumor protein D52." 08/01/2016 - "We discovered that K(lysine) acetyltransferase 8 (KAT8), a member of the MOZ, YBF2/SAS2, and TIP 60 protein 1 (MYST) family of histone acetyltransferases that catalyzes histone H4 lysine 16 acetylation, colocalized with WDR5 at AR target genes, resulting in hormone-dependent gene activation in prostate cancer cells. "
4.	Genomic Instability 08/01/2010 - "Genetic studies indicate that Gcn5 and Rtt109, the H3K56Ac lysine acetyltransferase, function in parallel to maintain genome stability. " 10/01/2019 - "Here, we show that loss of the lysine acetyltransferase MOF or its associated NSL-complex members KANSL2 or KANSL3 leads to a stochastic accumulation of nuclear abnormalities with genomic instability patterns including chromothripsis. " 10/27/2017 - "K (lysine) acetyltransferase 8 (KAT8), an acetyltransferase that specifically catalyzes histone H4 lysine 16 acetylation, is critical for key biological processes including cell proliferation and maintenance of genome stability. "
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2022 - "The present study is designed to investigate the expressions of microRNA-143-3p (miR-143-3p) and Lysine acetyltransferase 6A (KAT6A) in acute myeloid leukemia (AML) samples and AML cell lines and to explore the possible effects and underlying mechanisms of miR-143-3p on the proliferation of AML cells. " 01/01/2018 - "We find that PRMT5 depletion or inhibition induces aberrant splicing of the multifunctional histone-modifying and DNA-repair factor TIP60/KAT5, which selectively affects its lysine acetyltransferase activity and leads to impaired HR. As HR deficiency sensitizes cells to PARP inhibitors, we demonstrate here that PRMT5 and PARP inhibitors have synergistic effects on acute myeloid leukemia cells." 11/01/2022 - "We focus on KAT2A, a lysine acetyltransferase responsible for histone H3 lysine 9 acetylation, which we recently identified as a dependence in acute myeloid leukemia stem cells and that participates in 2 distinct macromolecular complexes: Ada two-A-containing (ATAC) and Spt-Ada-Gcn5-Acetyltransferase (SAGA). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Lysine (L-Lysine)
3.	CREB-Binding Protein
4.	Heat-Shock Proteins (Heat-Shock Protein)
5.	Methyltransferases
6.	Caspase 8 (Caspase-8)
7.	Forkhead Transcription Factors (Forkhead Box Proteins)
8.	E2F Transcription Factors
9.	Proteasome Endopeptidase Complex (Proteasome)
10.	Ubiquitin-Conjugating Enzymes

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy