Perilipin-3

A perilipin that localizes to LIPID DROPLETS; CYTOPLASM; ENDOSOMES; and PLASMA MEMBRANE, especially in MACROPHAGES. It functions as a transporter of free fatty acids to lipid droplets to promote their biogenesis and growth. It is also required for the transport of the MANNOSE-6-PHOSPHATE RECEPTOR from endosomes to the TRANS-GOLGI NETWORK. Its structure consists of four helix bundles that interact with the hydrophobic lipid droplet surface.

Also Known As:

47 kDa MPR-binding Protein; 47 kDa Mannose 6-Phosphate Receptor-Binding Protein; Cargo Selection Protein TIP47; Mannose-6-Phosphate Receptor-Binding Protein 1; PLIN3 Protein; Perilipin 3 Protein; Placental Protein 17; TIP47 Protein; Tail Interacting Protein of 47 kDa; 47 kDa MPR binding Protein; 47 kDa Mannose 6 Phosphate Receptor Binding Protein; Mannose 6 Phosphate Receptor Binding Protein 1; Perilipin 3; Protein, PLIN3; Protein, Perilipin 3; Protein, TIP47

Networked: 23 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Lipid Droplet Associated Proteins: 28
      - Perilipins: 31
        Perilipin-3: 23
        human PLIN3 protein
        mouse Plin3 protein
        rat Plin3 protein

Experts

1.	Giatromanolaki, Alexandra: 2 articles (01/2022 - 08/2021)
2.	Kakouratos, Christos: 2 articles (01/2022 - 08/2021)
3.	Koukourakis, Michael I: 2 articles (01/2022 - 08/2021)
4.	Lamprou, Ioannis: 2 articles (01/2022 - 08/2021)
5.	Tsolou, Avgi: 2 articles (01/2022 - 08/2021)
6.	Xanthopoulou, Erasmia T: 2 articles (01/2022 - 08/2021)
7.	Nanos, Christos: 1 article (01/2022)
8.	Pavlidis, Pavlos: 1 article (01/2022)
9.	Sivridis, Efthimios: 1 article (01/2022)
10.	Tsaroucha, Alexandra: 1 article (01/2022)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2021 - "Conclusions: Our study demonstrated that ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3." 01/01/2021 - "ACSS3 represses prostate cancer progression through downregulating lipid droplet-associated protein PLIN3." 01/01/2022 - "Lipophagy-Related Protein Perilipin-3 and Resistance of Prostate Cancer to Radiation Therapy." 08/19/2021 - "Here, we sought to explore the role of lipid droplet-related protein perilipin-3 (PLIN3) in prostate cancer (PCa) chemotherapy. "
2.	Neoplasm Metastasis (Metastasis) 02/01/2009 - "The aim of this study was to find a possible clinical use of the tail-interacting protein of 47 kDa (TIP47) and further document its expression in smear cytology, different cervical dysplasias, invasive cervical cancer and metastasis. "
3.	Infections 08/04/2015 - "This study aimed at identifying potential microRNAs that modulate hepatic lipid droplets (LD) through targeting the Tail interacting protein of 47 kDa (TIP47) in HCV infection. "
4.	Uterine Cervical Neoplasms (Cancer of the Cervix) 02/01/2009 - "The aim of this study was to find a possible clinical use of the tail-interacting protein of 47 kDa (TIP47) and further document its expression in smear cytology, different cervical dysplasias, invasive cervical cancer and metastasis. "
5.	Uterine Cervical Dysplasia 02/01/2009 - "The aim of this study was to find a possible clinical use of the tail-interacting protein of 47 kDa (TIP47) and further document its expression in smear cytology, different cervical dysplasias, invasive cervical cancer and metastasis. "

Related Drugs and Biologics

1.	MicroRNAs (MicroRNA)
2.	Proteins (Proteins, Gene)
3.	Perilipin-2
4.	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)
5.	Sirolimus (Rapamycin)
6.	Palmitic Acid (Hexadecanoic Acid)
7.	Oleic Acid (Oleate)
8.	Nitric Oxide Synthase (NO Synthase)
9.	RNA-Binding Proteins (RNA-Binding Protein)
10.	Transcription Factors (Transcription Factor)

Related Therapies and Procedures

1.	Resistance Training
2.	Fat-Restricted Diet (Diet, Fat Restricted)
3.	Radiotherapy
4.	Drug Therapy (Chemotherapy)
5.	Endurance Training