Chronic Traumatic Encephalopathy

Degenerative brain disease linked to repetitive brain trauma. Progressive symptoms may include MEMORY LOSS; AGGRESSION; or DEPRESSION.

Also Known As:

Chronic Encephalopathy, Post-Concussive; Chronic Post-Concussive Encephalopathy; Chronic Post-Traumatic Encephalopathy; Encephalopathy, Post-Concussive; Encephalopathy, Post-Traumatic; Post-Concussive Encephalopathy; Post-Traumatic Encephalopathy; Traumatic Encephalopathy, Chronic; Chronic Encephalopathies, Post-Concussive; Chronic Encephalopathy, Post Concussive; Chronic Post Concussive Encephalopathy; Chronic Post Traumatic Encephalopathy; Chronic Post-Concussive Encephalopathies; Chronic Post-Traumatic Encephalopathies; Encephalopathies, Post-Concussive; Encephalopathies, Post-Traumatic; Encephalopathy, Post Concussive; Encephalopathy, Post Traumatic; Post Concussive Encephalopathy; Post Traumatic Encephalopathy; Post-Concussive Chronic Encephalopathies; Post-Concussive Chronic Encephalopathy; Post-Concussive Encephalopathies; Post-Traumatic Encephalopathies; Encephalopathy, Post-Traumatic, Chronic

Networked: 189 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease)
2.	Traumatic Brain Injuries (Traumatic Brain Injury)
3.	Tauopathies
4.	Parkinson Disease (Parkinson's Disease)
5.	Subdural Hematoma (Subdural Hemorrhage)

Experts

1.	McKee, Ann C: 22 articles (01/2022 - 05/2012)
2.	Stein, Thor D: 15 articles (01/2022 - 05/2012)
3.	Stern, Robert A: 14 articles (01/2022 - 05/2012)
4.	Alvarez, Victor E: 13 articles (01/2022 - 01/2013)
5.	Tripodis, Yorghos: 13 articles (01/2022 - 07/2015)
6.	Alosco, Michael L: 12 articles (01/2022 - 01/2017)
7.	Cantu, Robert C: 11 articles (01/2022 - 05/2012)
8.	Mez, Jesse: 11 articles (01/2022 - 07/2015)
9.	Kowall, Neil W: 9 articles (01/2022 - 05/2012)
10.	Huber, Bertrand R: 8 articles (01/2022 - 01/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chronic Traumatic Encephalopathy:

1.	Proteins (Proteins, Gene)FDA Link 01/01/2022 - "Using [3H]PBR-28, the target density of the 18 kDa translocator protein in healthy controls was 177.91 ± 56.96 nM (n = 7 cases; mean ± standard deviation); however, a highly variable target density (345.84 ± 372.42 nM; n = 11 cases; mean ± standard deviation) was measured in chronic traumatic encephalopathy. " 07/24/2020 - "However, immunohistochemistry against these and other proteins has not only allowed a more scientific evaluation of the pathology of AD but also revealed some mimics of HP-tau pathological patterns of AD, including age-related changes, argyrophilic grain disease and chronic traumatic encephalopathy. " 01/01/2020 - "Biomolecules in solutions subjected to extensional strain can form aggregates, which may be important for our understanding of pathologies involving insoluble protein structures where mechanical forces are thought to be causative (e.g., tau fibers in chronic traumatic encephalopathy (CTE)). " 01/01/2019 - "Protein shapes at the core of chronic traumatic encephalopathy." 09/01/2018 - "Thus, MCC-induced chronic traumatic encephalopathy can increase the expressions of p-tau and Aβ1-40 proteins in the hippocampal and septal areas, leading to damage of hippocampal and septal neurons and increasing the number of astrocytes in the hippocampal and septal areas, ultimately damaging the balance motion behavior and learning, as well as memory abilities of rats."
2.	Dronabinol (THC)FDA LinkGeneric 01/01/2018 - "This review will examine the intriguing promise that recent discoveries regarding cannabis-based medicines offer to neurological therapeutics by incorporating the neutral phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the putative treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson disease (PD), Alzheimer disease (AD) and traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE). "
3.	Terpenes (Terpenoids)IBA 01/01/2018 - "This review will examine the intriguing promise that recent discoveries regarding cannabis-based medicines offer to neurological therapeutics by incorporating the neutral phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the putative treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson disease (PD), Alzheimer disease (AD) and traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE). "
4.	CannabidiolIBA 01/01/2018 - "This review will examine the intriguing promise that recent discoveries regarding cannabis-based medicines offer to neurological therapeutics by incorporating the neutral phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the putative treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson disease (PD), Alzheimer disease (AD) and traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE). "
5.	Alkaline PhosphataseIBA 11/16/2015 - "Dephosphorylation of phosphorylated Tau (pTau) protein, which is essential for the preservation of neuronal microtubule assemblies and for protection against trauma-induced tauopathy and chronic traumatic encephalopathy (CTE), is primarily achieved in brain by tissue non-specific alkaline phosphatase (TNAP). "
6.	AcidsIBA 01/01/2018 - "This review will examine the intriguing promise that recent discoveries regarding cannabis-based medicines offer to neurological therapeutics by incorporating the neutral phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the putative treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson disease (PD), Alzheimer disease (AD) and traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE). "
7.	pyrimidineIBA 07/17/2019 - "The LD50 (per os) for the test-object was 4973.56 ± 573.72 mg/kg. Conclusion: Based on the obtained data, high therapeutic efficacy and low systemic toxicity of the application are assumed 4-{2-[2-(3,4-dimethoxyphenyl)-vinyl]-6-ethyl-4-oxo-5-phenyl-4H-pyrimidine-1-Il}benzsulfamide in chronic traumatic encephalopathy." 07/17/2019 - "Background and objectives: To evaluate the effect of a new pyrimidine derivative on the change of mitochondrial function in experimental chronic traumatic encephalopathy. " 07/17/2019 - "The Administration of the New Pyrimidine Derivative-4-{2-[2-(3,4-Dimethoxyphenyl)-Vinyl]-6-Ethyl-4-Oxo-5-Phenyl-4H-Pyrimidine-1-Il}Benzsulfamide Restores the Activity of Brain Cells in Experimental Chronic Traumatic Encephalopathy by Maintaining Mitochondrial Function."
8.	cannabidiolic acidIBA 01/01/2018 - "This review will examine the intriguing promise that recent discoveries regarding cannabis-based medicines offer to neurological therapeutics by incorporating the neutral phytocannabinoids tetrahydrocannabinol (THC), cannabidiol (CBD), their acidic precursors, tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA), and cannabis terpenoids in the putative treatment of five syndromes, currently labeled recalcitrant to therapeutic success, and wherein improved pharmacological intervention is required: intractable epilepsy, brain tumors, Parkinson disease (PD), Alzheimer disease (AD) and traumatic brain injury (TBI)/chronic traumatic encephalopathy (CTE). "
9.	Biomarkers (Surrogate Marker)IBA 01/01/2016 - "Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy." 08/08/2023 - "Blood-Based Biomarkers in the Diagnosis of Chronic Traumatic Encephalopathy: Research to Date and Future Directions." 02/01/2022 - "The diagnostic potential of fluid and imaging biomarkers in chronic traumatic encephalopathy (CTE)." 01/01/2022 - "Potential blood biomarkers for chronic traumatic encephalopathy: The multi-omics landscape of an observational cohort." 01/01/2022 - "Characterization of neuroinflammatory positron emission tomography biomarkers in chronic traumatic encephalopathy."
10.	tau Proteins (tau Protein)IBA 04/01/2023 - "Diagnostic Prospectives with Tau Protein and Imaging Techniques to Detect Development of Chronic Traumatic Encephalopathy." 01/01/2021 - "Astrocytes with intracellular accumulations of misfolded phosphorylated tau protein have been observed in advanced-stage chronic traumatic encephalopathy (CTE) and in other neurodegenerative conditions. " 10/01/2019 - "Introduction: Chronic Traumatic Encephalopathy (CTE) is a neuropathological disease defined by perivascular hyperphosphorylated tau protein depositions in a patchy distribution at the depths of cortical sulci in the brain. " 01/01/2016 - "Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. " 01/01/2016 - "Chronic traumatic encephalopathy (CTE) is a neurological and psychiatric condition marked by preferential perivascular foci of neurofibrillary and glial tangles (composed of hyperphosphorylated-tau proteins) in the depths of the sulci. "

Therapies and Procedures

1.	Therapeutics 11/01/2006 - "Further studies are needed to identify and define the neuropathological cascades of chronic traumatic encephalopathy in football players, which may form the basis for prophylaxis and therapeutics." 01/01/2023 - "Two topical issues in this field are "The association between TBI and dementia-related alterations" and "chronic traumatic encephalopathy (CTE)." Studies on clinical manifestation, therapy, pathology, and pathogenic mechanisms are also popular in the field." 01/01/2022 - "With repetitive head trauma being linked to devastating medium - and long-term maladaptive neurobehavioral outcomes, including chronic traumatic encephalopathy (CTE), understanding the hyperacute cellular mechanisms can help understand the course of the pathology and the development of effective therapeutics." 01/01/2019 - "Therapies that target this process might in warfighters might function either by attenuating the development of post-traumatic stress disorder, chronic traumatic encephalopathy and Alzheimer's disease, or by slowing their progression." 01/01/2019 - "This review summarizes the current knowledge and concepts regarding the connection between long-term consequences of TBI and aging-associated neurodegenerative disorders including Alzheimer's disease (AD), chronic traumatic encephalopathy (CTE), and Parkinsonism, with implications for novel therapy targets. "
2.	Vagus Nerve Stimulation 04/01/2013 - "This special issue of Neurological Research provides a broad coverage of several important topics in TBI, including contemporary imaging of mild TBI, management of chronic subdural hematoma (cSDH), use of vagus nerve stimulation (VNS) to treat TBI, reviews on blast TBI and chronic traumatic encephalopathy (CTE), as well as basic science studies in different rodent models of TBI. "
3.	Precision Medicine 01/01/2018 - "chronic traumatic encephalopathy and Alzheimer's disease), and as theranostic tools in pre-clinical and clinical settings. "
4.	Low-Level Light Therapy (LLLT) 01/01/2023 - "Transcranial Photobiomodulation Treatment: Significant Improvements in Four Ex-Football Players with Possible Chronic Traumatic Encephalopathy."
5.	Exercise Therapy (Therapy, Exercise) 01/01/2023 - "The benefits of rehabilitation exercise in improving chronic traumatic encephalopathy: recent advances and future perspectives."