Type II Secretion Systems

Gram-negative bacterial secretion systems which carry out the secretion of folded proteins.T2SSs secrete folded proteins from the PERIPLASMIC SPACE that have been exported there by SEC TRANSLOCASE or TAT SECRETION SYSTEMS, or they secrete folded proteins directly from the CYTOPLASM. The T2SSs have four substructures, an ATPase, an inner membrane platform, a pseudopilin, and secretin, an outer membrane complex which is a channel for secretion. (This bacterial secretin is not the same as the mammalian hormone also named SECRETIN.)

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Networked: 20 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Shanks, Robert M Q: 2 articles (01/2020 - 12/2019)
2.	Bain, William: 2 articles (12/2019 - 01/2018)
3.	Cheng, Zhenyu: 2 articles (12/2019 - 01/2018)
4.	Hulver, Mei: 2 articles (12/2019 - 01/2018)
5.	Lee, Janet S: 2 articles (12/2019 - 01/2018)
6.	Olonisakin, Tolani: 2 articles (12/2019 - 01/2018)
7.	Pilewski, Joseph: 2 articles (12/2019 - 01/2018)
8.	Qu, Yanyan: 2 articles (12/2019 - 01/2018)
9.	Ray, Anuradha: 2 articles (12/2019 - 01/2018)
10.	Ray, Prabir: 2 articles (12/2019 - 01/2018)

Related Diseases

1.	Infections 12/20/2022 - "solanacearum Type II Secretion System (T2SS) plays a key role in phiAP1 infection. " 05/15/2011 - "The role of toxins secreted by the type II secretion system (T2SS) of Pseudomonas aeruginosa during lung infection has been uncertain despite decades of research. " 05/15/2011 - "Type II secretion system of Pseudomonas aeruginosa: in vivo evidence of a significant role in death due to lung infection." 01/01/2022 - "carotovorum and lacks the Out cluster of the Type II secretion system while harboring a siderophore that causes a unique pink pigmentation during soft rot infections. " 12/14/2020 - "We found that the secretin GspD of the type II secretion system (T2S) of Leptospira interrogans serovar Canicola was highly conserved amongst pathogenic serovars and was expressed in vivo during infection, as shown by immunohistochemistry. "
2.	Diarrhea 01/01/2023 - "The GspD secretin is the outer membrane channel of the bacterial type II secretion system (T2SS) which secrets diverse toxins that cause severe diseases such as diarrhea and cholera. " 01/10/2023 - "The GspD secretin is the outer membrane channel of the bacterial type II secretion system (T2SS) which secrets diverse effector proteins or toxins that cause severe diseases such as diarrhea and cholera. "
3.	Cholera 01/01/2023 - "The GspD secretin is the outer membrane channel of the bacterial type II secretion system (T2SS) which secrets diverse toxins that cause severe diseases such as diarrhea and cholera. " 01/10/2023 - "The GspD secretin is the outer membrane channel of the bacterial type II secretion system (T2SS) which secrets diverse effector proteins or toxins that cause severe diseases such as diarrhea and cholera. "
4.	Lung Injury 12/01/2019 - "Cell-free supernatant from PA with genetic deletion of the type 2 secretion system, but not the type 3 secretion system, mitigated lung epithelial cell death in vitro and lung injury in Mpl -/- mice. "
5.	Bacteremia 01/01/2017 - "Using a murine model for bacteremia, we have previously shown that the type II secretion system (T2SS) contributes to in vivo fitness of A. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Virulence Factors (Pathogenicity Factors)
3.	Secretin
4.	Type III Secretion Systems
5.	Ion Channels (Ion Channel)
6.	Metalloproteases (Metalloproteinases)
7.	Salmonella Vaccines
8.	Siderophores
9.	Xylose (D-Xylose)
10.	Enterotoxins (Enterotoxin)