Type I Secretion Systems

Gram-negative bacterial secretion systems which translocate effectors in a single step across the inner and outer membranes. The one-step secretion is carried out by a channel that passes from the CYTOPLASM, through the inner membrane, PERIPLASMIC SPACE, and outer membrane, to the EXTRACELLULAR SPACE. The specificity of type I secretions systems are determined by the specificity of the three subcomponents forming the channel - an ATP transporter (ATP-BINDING CASSETTE TRANSPORTERS); a membrane fusion protein (MEMBRANE FUSION PROTEINS); and an outer membrane protein (BACTERIAL OUTER MEMBRANE PROTEINS.)

Also Known As:

Bacterial Secretion Systems, Type I; T1SS Secretion System; Type 1 Secretion System; Type 1 Secretion Systems; Type I Secretion System; Secretion System, T1SS; System, T1SS Secretion

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Protein Translocation Systems: 7
    - Bacterial Secretion Systems: 16
      - Type I Secretion Systems: 4

Experts

1.	Cao, Sanjie: 1 article (09/2019)
2.	Han, Xinfeng: 1 article (09/2019)
3.	Huang, Xiaobo: 1 article (09/2019)
4.	Huang, Yong: 1 article (09/2019)
5.	Li, Ying: 1 article (09/2019)
6.	Ma, Xiaoping: 1 article (09/2019)
7.	Miao, Chang: 1 article (09/2019)
8.	Wen, Xintian: 1 article (09/2019)
9.	Wen, Yiping: 1 article (09/2019)
10.	Wu, Rui: 1 article (09/2019)

Related Diseases

1.	Infections 09/01/2019 - "TolC is the outer membrane channel component of type 1 secretion systems and multidrug efflux pumps that plays critical roles during the infection process in many pathogens. " 01/01/2019 - "Notably, a virulence factor named TesG, which is controlled by the vital quorum-sensing system and secreted by the downstream type I secretion system, can suppress the host inflammatory response and facilitate the development of chronic lung infection. " 01/01/2023 - "The type I secretion system (T1SS) protein SiiD was demonstrated to repress the NLRP3 inflammasome activation during SE infection and was the first to reveal the antagonistic role of T1SS in the inflammasome pathway. "
2.	Inflammation (Inflammations) 01/01/2022 - "From this list, we characterized a giant RTX adhesin encoded downstream of a type one secretion system (T1SS) that mediates bacterial binding and entry into host macrophages, an important first step toward cellular toxicity and inflammation. "

Related Drugs and Biologics

1.	Inflammasomes
2.	Virulence Factors (Pathogenicity Factors)
3.	Proteins (Proteins, Gene)
4.	Ion Channels (Ion Channel)