CELF1 Protein

A member of the CELF PROTEINS family which binds GU rich elements (GREs) and CUG-triplet repeats in the 3'UTR of mammalian mRNA transcripts that undergo rapid turnover. It also binds AU-rich elements (AREs or EDEN-like) in the 3'UTR of JUN and FOS mRNAs. Mutations in the human CELF1 gene are associated with MYOTONIC DYSTROPHY type 1.

Also Known As:

BRUNOL2 Protein; Bruno-Like 2 Protein; CUG Triplet Repeat, RNA-Binding Protein 1; CUGBP, Elav-Like Family Member 1 Protein; CUGBP1 Protein; 2 Protein, Bruno-Like; Bruno Like 2 Protein; CUG Triplet Repeat, RNA Binding Protein 1; CUGBP, Elav Like Family Member 1 Protein; Protein, BRUNOL2; Protein, Bruno-Like 2; Protein, CELF1; Protein, CUGBP1

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chaudhury, Arindam: 1 article (11/2016)
2.	Cheema, Shebna: 1 article (11/2016)
3.	Fachini, Joseph M: 1 article (11/2016)
4.	Hilsenbeck, Susan G: 1 article (11/2016)
5.	Ittmann, Michael M: 1 article (11/2016)
6.	Kongchan, Natee: 1 article (11/2016)
7.	Lu, Guojun: 1 article (11/2016)
8.	Mao, Sufeng: 1 article (11/2016)
9.	Neilson, Joel R: 1 article (11/2016)
10.	Rosen, Daniel G: 1 article (11/2016)

Related Diseases

1.	Carcinogenesis 12/22/2015 - "Finally, we provide evidence that reduction of CELF1 protein using a xenograft tumorigenesis mouse model decreased tumor growth. "
2.	Neoplasms (Cancer) 12/22/2015 - "Finally, we provide evidence that reduction of CELF1 protein using a xenograft tumorigenesis mouse model decreased tumor growth. "
3.	Myotonic Dystrophy (Dystrophia Myotonica) 03/15/2014 - "High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines."
4.	Myotonia 02/19/2008 - "These mice recapitulate many findings associated with DM1 skeletal muscle, such as CUG RNA foci with Muscleblind-like 1 (MBNL1) protein colocalization, misregulation of developmentally regulated alternative splicing events, myotonia, characteristic histological abnormalities, and increased CUGBP1 protein levels. "
5.	Insulin Resistance 05/01/2003 - "It was previously shown that delay of muscle differentiation and insulin resistance in DM1 are associated with misregulation of CUGBP1 protein levels. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	RNA (Ribonucleic Acid)
3.	Proteins (Proteins, Gene)