5-Aminolevulinate Synthetase

An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.

Also Known As:

5-Aminolevulinate Synthase; delta-Aminolevulinic Acid Synthetase; 5 Aminolevulinate Synthase; 5 Aminolevulinate Synthetase; Acid Synthetase, Aminolevulinic; Acid Synthetase, delta-Aminolevulinic; Synthase, 5-Aminolevulinate; Synthase, delta-Aminolevulinate; Synthetase, 5-Aminolevulinate; Synthetase, Aminolevulinic Acid; Synthetase, delta-Aminolevulinic Acid; delta Aminolevulinate Synthase; delta Aminolevulinic Acid Synthetase; Aminolevulinic Acid Synthetase; delta-Aminolevulinate Synthase; Succinyl-CoA:glycine C-Succinyltransferase (decarboxylating)

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - 5-Aminolevulinate Synthetase: 109

mouse ALAS2 protein

Bio-Agent Context: Research Results