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NOX-A12

Also Known As:

spiegelmer NOX-A12

Networked: 7 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Polynucleotides: 218
    - Oligonucleotides: 5145
      - Nucleotide Aptamers: 598
        NOX-A12: 7

Experts

1.	Eulberg, Dirk: 2 articles (12/2017 - 11/2017)
2.	Kruschinski, Anna: 2 articles (12/2017 - 02/2014)
3.	Vater, Axel: 2 articles (11/2017 - 11/2012)
4.	Zboralski, Dirk: 2 articles (11/2017 - 02/2014)
5.	Mehrpouri, Mahdieh: 1 article (04/2022)
6.	Arya, Rakesh K: 1 article (01/2021)
7.	Chaturvedi, Priyank: 1 article (01/2021)
8.	Datta, Dipak: 1 article (01/2021)
9.	Gupta, Annapurna: 1 article (01/2021)
10.	Maheshwari, Shrankhla: 1 article (01/2021)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2017 - "The findings were validated in vivo in a syngeneic murine model of colorectal cancer in which the addition of NOX-A12 improved anti-PD-1 therapy. "
2.	Hematologic Neoplasms (Hematological Malignancy) 04/05/2022 - "Plerixafor, BKT140, LY2510924, PF-06747143, ulocuplumab, and NOX-A12 are among the most well-known CXCR4 and CXCL12 modulators that their therapeutic efficacies have been evaluated in different pre-clinical and clinical studies of hematologic malignancies. "
3.	Pulmonary Hypertension 11/01/2012 - "To study the effects of blocking SDF-1, rats with monocrotaline-induced pulmonary hypertension were treated with NOX-A12 from Day 21 to Day 35 after monocrotaline administration. " 11/01/2012 - "To systematically evaluate the number and cross-sectional distribution of inflammatory cells in different sizes of pulmonary arteries from explanted lungs of patients with idiopathic PAH versus healthy donor lungs and to demonstrate functional relevance by blocking stromal-derived factor-1 by the Spiegelmer NOX-A12 in monocrotaline-induced pulmonary hypertension in rats. "
4.	Neoplasms (Cancer) 11/01/2017 - "Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade." 01/01/2021 - "However, blockade of CXCL12-CXCR4 signaling axis by inhibitors like Nox-A12, FDA approved CXCR4 inhibitor drug AMD3100 have shown limited clinical success in cancer treatment. " 07/01/2013 - "In conclusion, NOX-A12 may be appropriate for therapeutic use in and beyond mobilization of HSCs, e.g., in long-lasting mobilization and chemosensitization of hematological cancer cells."
5.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 12/15/2017 - "These results are consistent with our in vivo findings using a functional pre-clinical mouse model of chronic myeloid leukemia (CML), whereby we demonstrated the ability of NOX-A12, combined with the ABL kinase inhibitor, nilotinib, to reduce the leukemia burden in mice to a greater extent than either agent alone. "

Related Drugs and Biologics

1.	plerixafor
2.	Monocrotaline
3.	ulocuplumab
4.	BKT140
5.	LY2510924
6.	Nucleotide Aptamers
7.	Therapeutic Uses
8.	RNA (Ribonucleic Acid)
9.	Protein-Tyrosine Kinases (Tyrosine Kinase)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Therapeutics