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5- ((4- (5- (7,7- dimethyl- 1,6- dioxaspiro(2.5)octan- 5- yl)- 3- methylpenta- 2,4- dien- 1- yl)cyclohexyl)amino)- 5- oxopent- 3- en- 2- yl methylcarbamate

structure in first source

Also Known As:

sudemycin D6

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Cyclohexylamines: 33
    - 5-((4-(5-(7,7-dimethyl-1,6-dioxaspiro(2.5)octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)amino)-5-oxopent-3-en-2-yl methylcarbamate: 3
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - 5-((4-(5-(7,7-dimethyl-1,6-dioxaspiro(2.5)octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)amino)-5-oxopent-3-en-2-yl methylcarbamate: 3
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        Cyclohexylamines: 33
        5-((4-(5-(7,7-dimethyl-1,6-dioxaspiro(2.5)octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)amino)-5-oxopent-3-en-2-yl methylcarbamate: 3
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - 5-((4-(5-(7,7-dimethyl-1,6-dioxaspiro(2.5)octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)amino)-5-oxopent-3-en-2-yl methylcarbamate: 3

Experts

1.	Webb, Thomas R: 3 articles (01/2017 - 12/2013)
2.	Stamm, Stefan: 2 articles (01/2017 - 08/2015)
3.	Lagisetti, Chandraiah: 2 articles (08/2015 - 12/2013)
4.	Palacios, Gustavo: 2 articles (08/2015 - 12/2013)
5.	Danzer, Barbara: 1 article (01/2017)
6.	Thurman, Morgan: 1 article (01/2017)
7.	van Doorn, Jacob: 1 article (01/2017)
8.	Joyner, Amanda S: 1 article (08/2015)
9.	Potter, Philip M: 1 article (08/2015)
10.	Sambucetti, Lidia C: 1 article (08/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "The aim of the study was to define pharmacodynamic markers for sudemycin D6, an experimental cancer drug that changes alternative splicing in human blood. " 08/01/2015 - "We also demonstrate dose- and time-dependent on-target activity of sudemycin D6 (SD6), which leads to dramatic tumor regression. " 12/27/2013 - "Our work supports the idea that sudemycin D6 is worthy of further investigation as a novel preclinical anticancer agent with application in the treatment of numerous human cancers. "
2.	Melanoma (Melanoma, Malignant) 12/27/2013 - "This optimization culminated in the discovery of sudemycin D6, which shows potent cytotoxic activity in the melanoma line SK-MEL-2 (IC50 = 39 nM) and other tumor cell lines, including JeKo-1 (IC50 = 22 nM), HeLa (IC50 = 50 nM), and SK-N-AS (IC50 = 81 nM). "

Related Drugs and Biologics

1.	Antineoplastic Agents (Antineoplastics)