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CLP257

a chloride extrusion enhancer that targets KCC2; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiazolidines: 105
      - CLP257: 3

Experts

1.	Akopian, Armen N: 1 article (01/2022)
2.	Cai, Jinxia: 1 article (01/2022)
3.	Chen, Xiaodan: 1 article (01/2022)
4.	David, Eric T: 1 article (01/2022)
5.	De Koninck, Yves: 1 article (01/2022)
6.	Driskill, Christopher: 1 article (01/2022)
7.	Dussor, Gregory: 1 article (01/2022)
8.	Feldhaus, Andrew L: 1 article (01/2022)
9.	Ferrini, Francesco: 1 article (01/2022)
10.	Gao, Yuan: 1 article (01/2022)

Related Diseases

1.	Hypersensitivity (Allergy) 01/01/2022 - "However, KCC2 hypofunction promotes mechanical pain hypersensitivity in both sexes because CLP257 alleviated hyperalgesic priming in male and female mice. " 01/01/2022 - "This CGRP-induced mechanical hypersensitivity was reversed by olcegepant and the KCC2 enhancer CLP257, suggesting a role for anionic plasticity in the dorsal horn in the pain-promoting effects of CGRP in females. " 01/01/2022 - "Both muscimol and CLP257 could dose-dependently inhibit mechanical hypersensitivity caused by remifentanil-induced downregulation of GABAAα2R and KCC2, respectively. "
2.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2021 - "Here, we used the recently developed KCC2 enhancer, CLP257, to evaluate the effects of acutely increasing KCC2 extrusion capability on spastic symptoms after chronic SCI. Sprague Dawley rats received a spinal cord transection at T12 and were either bike-trained or remained sedentary for 5 weeks. "
3.	Pain (Aches) 01/01/2022 - "However, KCC2 hypofunction promotes mechanical pain hypersensitivity in both sexes because CLP257 alleviated hyperalgesic priming in male and female mice. " 01/01/2022 - "This CGRP-induced mechanical hypersensitivity was reversed by olcegepant and the KCC2 enhancer CLP257, suggesting a role for anionic plasticity in the dorsal horn in the pain-promoting effects of CGRP in females. "
4.	Muscle Spasticity (Spastic) 01/01/2021 - "Here, we used the recently developed KCC2 enhancer, CLP257, to evaluate the effects of acutely increasing KCC2 extrusion capability on spastic symptoms after chronic SCI. Sprague Dawley rats received a spinal cord transection at T12 and were either bike-trained or remained sedentary for 5 weeks. "
5.	Hyperalgesia 01/01/2022 - "Therefore, we evaluated the role of GABA type A receptor (GABAAR) agonist (muscimol), KCC2 enhancer (CLP257) in remifentanil-induced hyperalgesia, as well as GABA and KCC2 receptors responses in the dorsal spinal horn. "

Related Drugs and Biologics

1.	Muscimol
2.	gamma-Aminobutyric Acid (GABA)
3.	Remifentanil (Ultiva)
4.	olcegepant