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papuamine

antineoplastic from an Indonesian sponge Haliclona sp.; structure in first source

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - papuamine: 5

Experts

1.	Ishikawa, Masaaki: 3 articles (08/2014 - 01/2013)
2.	Kanno, Syu-Ichi: 3 articles (08/2014 - 01/2013)
3.	Mangindaan, Remy E P: 3 articles (08/2014 - 01/2013)
4.	Namikoshi, Michio: 3 articles (08/2014 - 01/2013)
5.	Yamazaki, Hiroyuki: 3 articles (08/2014 - 01/2013)
6.	Tomizawa, Ayako: 2 articles (08/2014 - 11/2013)
7.	Ukai, Kazuyo: 2 articles (08/2014 - 11/2013)
8.	Yomogida, Shin: 2 articles (08/2014 - 11/2013)
9.	Jung, Yujin: 1 article (01/2020)
10.	Lee, Ho-Young: 1 article (01/2020)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 11/01/2013 - "In this study, we examine the cytotoxic mechanism of the major chemical compound, papuamine, on MCF-7 human breast cancer cells. " 11/01/2013 - "Papuamine causes autophagy following the reduction of cell survival through mitochondrial damage and JNK activation in MCF-7 human breast cancer cells." 08/01/2014 - "The major cytotoxic chemical compound was identified as papuamine, which caused reduction of cell survival through activation of c-Jun N-terminal kinase (JNK) in human breast cancer MCF-7 cells. " 08/01/2014 - "Combined effect of papuamine and doxorubicin in human breast cancer MCF-7 cells."
2.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2020 - "Papuamine Inhibits Viability of Non-small Cell Lung Cancer Cells by Inducing Mitochondrial Dysfunction." 01/01/2020 - "Papuamine depleted intracellular ATP by causing mitochondrial dysfunction, as indicated by the loss of the mitochondrial membrane potential and increased mitochondrial superoxide generation. "
3.	Neoplasms (Cancer) 01/01/2013 - "Papuamine and haliclonadiamine, obtained from an Indonesian sponge Haliclona sp., inhibited cell proliferation of human cancer cell lines." 01/01/2013 - "Bioassay-guided isolation yielded two pentacyclic alkaloids, papuamine (1) and haliclonadiamine (2), which inhibited cell proliferation of six human cancer cell lines with IC50 values of 0.93-1.50 and 1.00-4.44 µM, respectively. "
4.	Glioblastoma (Glioblastoma Multiforme) 03/27/2015 - "Biological evaluations of 1-4 revealed that papuamine is cytotoxic against glioblastoma SF-295 cells (GI50 = 0.8 μM)."
5.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2020 - "Using human non-small cell lung cancer (NSCLC) cell lines (H1299, H226B, and A549), cell viability and colony formation assays, cell cycle analysis, and immunoblotting were performed to determine cytotoxic and proapoptotic effects of papuamine. " 01/01/2020 - "Papuamine Inhibits Viability of Non-small Cell Lung Cancer Cells by Inducing Mitochondrial Dysfunction."

Related Drugs and Biologics

1.	JNK Mitogen-Activated Protein Kinases
2.	Superoxides (Superoxide)
3.	Doxorubicin (Adriamycin)
4.	Alkaloids
5.	Adenosine Triphosphate (ATP)
6.	haliclonadiamine