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N- ((4- bromo- 2- ((trifluoromethyl)oxy)phenyl)methyl)- 1- (4- methyl- 6- (methylamino)- 1,3,5- triazin- 2- yl)- 4- piperidinecarboxamide

inhibits soluble epoxide hydrolase; structure in first source

Also Known As:

GSK2188931

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Triazines: 306
    - N-((4-bromo-2-((trifluoromethyl)oxy)phenyl)methyl)-1-(4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)-4-piperidinecarboxamide: 1
  - Piperidines: 17
    - N-((4-bromo-2-((trifluoromethyl)oxy)phenyl)methyl)-1-(4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)-4-piperidinecarboxamide: 1

Experts

1.	Behm, David J: 1 article (04/2013)
2.	Eisennagel, Stephen H: 1 article (04/2013)
3.	Hoang, Bao: 1 article (04/2013)
4.	Jucker, Beat M: 1 article (04/2013)
5.	Marino, Joseph P: 1 article (04/2013)
6.	Morgan, Lisa A: 1 article (04/2013)
7.	Olzinski, Alan R: 1 article (04/2013)
8.	Tunstead, James R: 1 article (04/2013)
9.	Upson, John J: 1 article (04/2013)
10.	Wang, Tao: 1 article (04/2013)

Related Diseases

1.	Hypertrophy 04/01/2013 - "In rats, although GSK2188931 prevented TAC-mediated increases in certain genes associated with hypertrophy and fibrosis (α-skeletal actin and connective tissue growth factor), the compound failed to attenuate TAC-induced increases in left ventricle mass, posterior wall thickness, end-diastolic volume and pressure, and perivascular fibrosis. "
2.	Cardiomegaly (Heart Hypertrophy) 04/01/2013 - "We examined the ability of sEH inhibitors GSK2188931 and GSK2256294 to modulate cardiac hypertrophy, fibrosis, and function after transverse aortic constriction (TAC) in rats and mice. "
3.	Fibrosis (Cirrhosis) 04/01/2013 - "In rats, although GSK2188931 prevented TAC-mediated increases in certain genes associated with hypertrophy and fibrosis (α-skeletal actin and connective tissue growth factor), the compound failed to attenuate TAC-induced increases in left ventricle mass, posterior wall thickness, end-diastolic volume and pressure, and perivascular fibrosis. " 04/01/2013 - "We examined the ability of sEH inhibitors GSK2188931 and GSK2256294 to modulate cardiac hypertrophy, fibrosis, and function after transverse aortic constriction (TAC) in rats and mice. "

Related Drugs and Biologics

1.	Connective Tissue Growth Factor
2.	N- ((4- cyano- 2- (trifluoromethyl)phenyl)methyl)- 3- ((4- methyl- 6- (methylamino)- 1,3,5- triazin- 2- yl)amino)cyclohexanecarboxamide