4- ethyl- 5- methyl- 5,6- dihydro(1,3)dioxolo(4,5- j)phenanthridine

activates the Wnt/beta-catenin signaling pathway; structure in first source

Also Known As:

HLY78

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Benzodioxoles: 3
      - 4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzodioxoles: 3
      - 4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine: 5
  - 3-Ring Heterocyclic Compounds
    - Phenanthridines: 3
      - 4-ethyl-5-methyl-5,6-dihydro(1,3)dioxolo(4,5-j)phenanthridine: 5

Experts

1.	Cheng, Yuan: 2 articles (10/2020 - 01/2020)
2.	Li, Lina: 2 articles (10/2020 - 01/2020)
3.	Luo, Xu: 2 articles (10/2020 - 01/2020)
4.	Xie, Zongyi: 2 articles (10/2020 - 01/2020)
5.	Xu, Weilin: 1 article (10/2020)
6.	Gu, Linggui: 1 article (01/2020)
7.	Li, Yuanyou: 1 article (01/2020)
8.	Zhang, Xiaolin: 1 article (01/2020)
9.	Zheng, Wen: 1 article (01/2020)
10.	Azad, Neelam: 1 article (08/2017)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2023 - "Activation of the Wnt-β-catenin pathway through HLY78 significantly suppressed the apoptosis of MG-63 cells, further suggesting the critical role of Wnt pathway in motility-regulated-apoptosis of tumor cells. " 05/24/2017 - "Overexpression of ORP8 resulted in a significant decrease in Wnt3a and β-catenin expression, and activation of Wnt signaling by HLY78 markedly blocked overexpression of ORP8-induced decrease in GC cell proliferation, formation of colonies, and implanted tumor growth. " 10/01/2020 - "Recently, HLY78 has been shown to inhibit apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway. " 08/01/2017 - "Co-treatment with salinomycin significantly potentiated the anti-cancer effects of resveratrol, whereas HLY78 co-treatment had minimal effect. "
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 01/01/2020 - "However, the effects of HLY78 on the BBB function in subarachnoid hemorrhage (SAH) are not yet validated. " 10/01/2020 - "HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats." 01/01/2020 - "HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats."
3.	Breast Neoplasms (Breast Cancer) 08/01/2017 - "Wnt modulators HLY78 (activator) and salinomycin (inhibitor) were evaluated in combination with resveratrol for their effect on breast cancer cell viability (MTT assay), cell cycle progression and apoptosis (Western blotting). "
4.	Brain Injuries (Brain Injury) 10/01/2020 - "HLY78 is a promising therapeutic agent to attenuate early brain injury after SAH."

Related Drugs and Biologics

1.	Catenins
2.	Carbon
3.	Resveratrol
4.	salinomycin