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Mn(III) ortho- tetrakis(N- hexylpyridinium- 2- yl)porphyrin

structure in first source

Also Known As:

MnTnHex-2-PyP5+

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Batinic-Haberle, Ines: 4 articles (10/2019 - 03/2008)
2.	Castro, Matilde: 2 articles (10/2019 - 01/2019)
3.	Costa, João G: 2 articles (10/2019 - 01/2019)
4.	Fernandes, Ana S: 2 articles (10/2019 - 01/2019)
5.	Oliveira, Nuno G: 2 articles (10/2019 - 01/2019)
6.	Saraiva, Nuno: 2 articles (10/2019 - 01/2019)
7.	Jiang, Chen: 2 articles (03/2018 - 03/2008)
8.	Owzar, Kouros: 2 articles (03/2018 - 03/2008)
9.	Vujaskovic, Zeljko: 2 articles (03/2018 - 03/2008)
10.	Almeida, Nuno: 1 article (01/2019)

Related Diseases

1.	Lung Injury 03/15/2008 - "This study shows that Fischer rats which were irradiated to their right hemithorax (28 Gy) have less pulmonary injury as measured using breathing frequencies when treated with daily subcutaneous injections of MnTE-2-PyP5+ (3 and 6 mg/kg) or MnTnHex-2-PyP5+ (0.3, 0.6, or 1.0 mg/kg) for 2 weeks after RT. "
2.	Kidney Neoplasms (Kidney Cancer) 10/17/2019 - "In this study, the exposure of 786-O human renal cancer cells to MnTnHex-2-PyP5+ (MnP), a very promising SODm, led to a concentration and time-dependent decrease in cell viability and in the cell proliferation indices, as well as to an increase in apoptosis. " 10/17/2019 - "The SOD Mimic MnTnHex-2-PyP5+ Reduces the Viability and Migration of 786-O Human Renal Cancer Cells."
3.	Pneumonia (Pneumonitis) 03/07/2018 - "We hypothesized that post-exposure treatment with the lipophilic mitochondrial superoxide dismutase mimetic, MnTnHex-2-PyP5+ (hexyl), would reduce radiation-induced pneumonitis and fibrosis in the lungs of nonhuman primates. "
4.	Neoplasms (Cancer) 11/07/2022 - "The manganese(III) porphyrin MnTnHex-2-PyP5+ (MnTnHex) is a potent superoxide dismutase mimic and modulator of redox-based transcriptional activity that has been studied in the context of different human disease models, including cancer. "
5.	Neoplasm Metastasis (Metastasis) 01/01/2019 - "In the present work, the impact of the MnP MnTnHex-2-PyP5+ in metastasis-related processes was assessed in breast cancer cells (MCF-7 and MDA-MB-231), alone or in combination with doxorubicin (dox). "

Related Drugs and Biologics

1.	manganese (III) meso- tetrakis(N- ethylpyridinium- 2- yl)porphyrin
2.	Superoxide Dismutase
3.	manganese(III) porphyrin
4.	Lipids
5.	Doxorubicin (Adriamycin)
6.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Subcutaneous Injections