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2-phenylquinoline-4-carboxylic acid (1,1- dioxo- 1H- 1lambda6- benzo(b)thiophen- 6- yl)amide

structure in first source

Also Known As:

HJC0123

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiophenes: 257
    - 2-phenylquinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo(b)thiophen-6-yl)amide: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - 2-phenylquinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo(b)thiophen-6-yl)amide: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - 2-phenylquinoline-4-carboxylic acid (1,1-dioxo-1H-1lambda6-benzo(b)thiophen-6-yl)amide: 2

Experts

1.	Chen, Haijun: 2 articles (01/2016 - 04/2013)
2.	Zhou, Jia: 2 articles (01/2016 - 04/2013)
3.	Bohanon, Fredrick J: 1 article (01/2016)
4.	Chen, Haiying: 1 article (01/2016)
5.	Corsello, Tiziana: 1 article (01/2016)
6.	Nunez Lopez, Omar: 1 article (01/2016)
7.	Radhakrishnan, Ravi S: 1 article (01/2016)
8.	Rojas-Khalil, Yesenia: 1 article (01/2016)
9.	Wang, Xiaofu: 1 article (01/2016)
10.	Ye, Na: 1 article (01/2016)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 04/01/2013 - "The most potent compound 5 (HJC0123) has demonstrated to inhibit STAT3 promoter activity, downregulate phosphorylation of STAT3, increase the expression of cleaved caspase-3, inhibit cell cycle progression and promote apoptosis in breast and pancreatic cancer cells with low micromolar to nanomolar IC50 values. "
2.	Neoplasms (Cancer) 04/01/2013 - "Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy."
3.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2016 - "These results demonstrate that HJC0123 represents a novel STAT3 inhibitor that suppresses the fibrogenic properties of HSCs, suggesting its therapeutic potential in liver fibrosis." 01/01/2016 - "STAT3 Inhibition Suppresses Hepatic Stellate Cell Fibrogenesis: HJC0123, a Potential Therapeutic Agent for Liver Fibrosis."

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)

Related Therapies and Procedures

1.	Therapeutics