HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

GSK5182

an estrogen-related receptor gamma inverse agonist

Networked: 15 relevant articles (4 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Stilbenes: 657
        Tamoxifen: 14288
        GSK5182: 15

Experts

1.	Lee, In-Kyu: 7 articles (12/2019 - 01/2012)
2.	Choi, Hueng-Sik: 5 articles (12/2019 - 01/2012)
3.	Kim, Don-Kyu: 4 articles (12/2019 - 01/2012)
4.	Cho, Sung Jin: 3 articles (12/2019 - 01/2017)
5.	Kim, Yong-Hoon: 3 articles (12/2019 - 09/2013)
6.	Lee, Chul-Ho: 3 articles (12/2019 - 09/2013)
7.	Catucci, Gianluca: 2 articles (03/2020 - 12/2018)
8.	Gilardi, Gianfranco: 2 articles (03/2020 - 12/2018)
9.	Sadeghi, Sheila J: 2 articles (03/2020 - 12/2018)
10.	Dooley, Steven: 2 articles (12/2019 - 01/2018)

Related Diseases

1.	Infertility (Sterility) 12/01/2018 - "The purpose of this study was to investigate the effect of the three common polymorphic variants of hFMO3 (V257M, E158K and E308G) on the metabolism and clearance of three structurally similar compounds: tamoxifen (breast cancer medication), clomiphene (infertility medication) and GSK5182 (antidiabetic lead molecule). "
2.	Breast Neoplasms (Breast Cancer) 12/01/2018 - "The purpose of this study was to investigate the effect of the three common polymorphic variants of hFMO3 (V257M, E158K and E308G) on the metabolism and clearance of three structurally similar compounds: tamoxifen (breast cancer medication), clomiphene (infertility medication) and GSK5182 (antidiabetic lead molecule). "
3.	Neoplasms (Cancer) 01/01/2020 - "We demonstrate that pharmacological inhibition of ERRγ with the selective inverse agonist GSK5182 increases antitumor efficacy of the chemotherapeutic paclitaxel on poor outcome BCa tumor organoids. " 03/04/2016 - "Small interfering RNA (siRNA)-mediated knockdown of ERRγ (siRNA-ERRγ) or an ERRγ inverse agonist, GSK5182, were also used to examine the effects of ERRγ inhibition on the proliferation and growth of a human hepatoma cell line, PLC/PRF/5. Immunohistochemical analysis revealed that tumor tissues showed higher levels of ERRγ-positivity than adjacent non-tumor lesions. "
4.	Fatty Liver 12/01/2019 - "Finally, an ERRγ inverse agonist, GSK5182, significantly ameliorates fatty liver disease in chronically alcohol-fed mice through inhibition of SREBP-1c-mediated fat accumulation. "
5.	Papillary Thyroid Cancer 01/01/2023 - "This finding helped us to further investigate the effects of GSK5182 on NIS function in papillary thyroid cancer (PTC) refractory to radioactive iodine (RAI) therapy. " 01/01/2023 - "We demonstrate that an inverse agonist of ERRγ, GSK5182, enhances the function of NIS protein via the modulation of ERRγ and MAP kinase signaling, thereby leading to increased responsiveness to radioiodine in RAI-refractory papillary thyroid cancer cells." 01/01/2023 - "An Inverse Agonist of Estrogen-Related Receptor Gamma, GSK5182, Enhances Na+/I- Symporter Function in Radioiodine-Refractory Papillary Thyroid Cancer Cells."

Related Drugs and Biologics

1.	Hypoglycemic Agents (Hypoglycemics)
2.	Tamoxifen
3.	Clomiphene (Clomifene)
4.	Paclitaxel (Taxol)
5.	Iodine
6.	Glucose (Dextrose)
7.	Enzymes
8.	Small Interfering RNA (siRNA)
9.	Proteins (Proteins, Gene)
10.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)

Related Therapies and Procedures

1.	Therapeutics