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2'-desoxy-9-erythromycylamine

structure in first source

Also Known As:

GS-459755

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - Polyketides: 231
    - Macrolides: 4391
      - Erythromycin: 3910
        2'-desoxy-9-erythromycylamine: 2

Experts

1.	Wilbert, Sibylle: 2 articles (01/2017 - 06/2013)
2.	Yeung, Arthur: 2 articles (01/2017 - 06/2013)
3.	Hamon, Rhys: 1 article (01/2017)
4.	Hodge, Greg: 1 article (01/2017)
5.	Hodge, Sandra: 1 article (01/2017)
6.	Jersmann, Hubertus: 1 article (01/2017)
7.	Reynolds, Paul N: 1 article (01/2017)
8.	Roscioli, Eugene: 1 article (01/2017)
9.	Tran, Hai B: 1 article (01/2017)
10.	Treiberg, Jennifer: 1 article (01/2017)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 06/01/2013 - "We conclude that GS-459755 may limit HNE-induced activation of ENaC and may be useful for the treatment of mucus dehydration in CF and COPD without inducing bacterial resistance."
2.	Dehydration (Water Stress) 06/01/2013 - "We conclude that GS-459755 may limit HNE-induced activation of ENaC and may be useful for the treatment of mucus dehydration in CF and COPD without inducing bacterial resistance."
3.	Lung Diseases (Lung Disease) 01/01/2017 - "We conclude that GS-459755 and GS-560660 may be useful for reducing airway inflammation in chronic lung diseases without inducing bacterial resistance." 06/01/2013 - "Since neutrophilia frequently occurs in chronic lung disease and human neutrophil elastase (HNE) induces mucus stasis by activating the epithelial sodium channel (ENaC), we tested the ability of GS-459755 to protect against HNE-induced mucus stasis. "
4.	Inflammation (Inflammations) 01/01/2017 - "We conclude that GS-459755 and GS-560660 may be useful for reducing airway inflammation in chronic lung diseases without inducing bacterial resistance."

Related Drugs and Biologics

1.	Epithelial Sodium Channels
2.	Leukocyte Elastase (Neutrophil Elastase)