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N1- (3,4- dichlorophenyl)- cyclohexane- 1,2- dicarboxamide

an mGlu4 agonist; structure in first source

Also Known As:

Lu AF21934

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Doller, Darío: 3 articles (01/2015 - 03/2013)
2.	Pilc, Andrzej: 3 articles (01/2015 - 08/2013)
3.	Gruca, Piotr: 2 articles (01/2015 - 08/2013)
4.	Papp, Mariusz: 2 articles (01/2015 - 08/2013)
5.	Sławińska, Anna: 2 articles (01/2015 - 08/2013)
6.	Wierońska, Joanna M: 2 articles (01/2015 - 08/2013)
7.	Zorn, Stevin H: 2 articles (01/2015 - 08/2014)
8.	Gołembiowska, Krystyna: 1 article (01/2015)
9.	Kłeczek, Natalia: 1 article (01/2015)
10.	Noworyta-Sokołowska, Karolina: 1 article (01/2015)

Related Diseases

1.	Tremor (Tremors) 08/01/2014 - "Lu AF21934 (0.5-5 mg/kg sc) did not influence tremor but at doses of 0.5 and 2.5 mg/kg reversed harmaline-induced hyperactivity. " 08/01/2014 - "Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats." 08/01/2014 - "The aim of the present study was to examine the effects of systemic administration of Lu AF21934, a brain-penetrating positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4), on the harmaline-induced tremor and other forms of motor activity in rats using fully automated Force Plate Actimeters. "
2.	Neurobehavioral Manifestations 01/01/2015 - "Lu AF21934, a positive allosteric modulator of the mGlu4 receptor, was previously shown to reverse behavioral phenotypes in animal models thought to mimic positive, negative, and cognitive symptoms of schizophrenia. " 08/01/2013 - "Because agonists at metabotropic glutamate receptors exert beneficial effects in schizophrenia, we have assessed the actions of Lu AF21934 and Lu AF32615, two chemically distinct, selective and brain-penetrant positive allosteric modulators (PAMs) of the mGlu4 receptor, in several tests reflecting positive, negative and cognitive symptoms of schizophrenia in rodents. "
3.	Schizophrenia (Dementia Praecox) 01/01/2015 - "Lu AF21934, a positive allosteric modulator of the mGlu4 receptor, was previously shown to reverse behavioral phenotypes in animal models thought to mimic positive, negative, and cognitive symptoms of schizophrenia. " 08/01/2013 - "Because agonists at metabotropic glutamate receptors exert beneficial effects in schizophrenia, we have assessed the actions of Lu AF21934 and Lu AF32615, two chemically distinct, selective and brain-penetrant positive allosteric modulators (PAMs) of the mGlu4 receptor, in several tests reflecting positive, negative and cognitive symptoms of schizophrenia in rodents. "
4.	Catalepsy 03/01/2013 - "In naïve rats, Lu AF21934 dose-dependently (10 and 30 mg/kg) alleviated haloperidol-induced catalepsy. "

Related Drugs and Biologics

1.	Harmaline
2.	metabotropic glutamate receptor 4
3.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
4.	Haloperidol (Haldol)