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2- hydroxy- 3- (5- ((morpholin- 4- yl)methyl)pyridin- 2- yl)- 1H- indole- 5- carbonitrile

structure in first source

Also Known As:

AZD1080

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 2-hydroxy-3-(5-((morpholin-4-yl)methyl)pyridin-2-yl)-1H-indole-5-carbonitrile: 3

Experts

1.	Chen, Shuo: 2 articles (05/2016 - 01/2016)
2.	Liu, Bo-Liang: 2 articles (05/2016 - 01/2016)
3.	Sun, Kai-Xuan: 2 articles (05/2016 - 01/2016)
4.	Zhao, Yang: 2 articles (05/2016 - 01/2016)
5.	Allen, Sean D: 1 article (01/2021)
6.	Chang, Chong Hyun: 1 article (01/2021)
7.	Jiang, Jinhong: 1 article (01/2021)
8.	Liao, Yu-Pei: 1 article (01/2021)
9.	Liu, Xiangsheng: 1 article (01/2021)
10.	Meng, Huan: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "IV injection of encapsulated AZD1080 also resulted in significant tumor shrinkage in other syngeneic mouse tumor models, including another colorectal tumor (CT26), as well as pancreas (KPC) and lung (LLC) cancer models. " 01/01/2021 - "In a MC38 colon cancer model, intravenous injection (IV) of silicasome-encapsulated AZD1080 significantly improved biodistribution and drug delivery to the tumor site. "
2.	Colonic Neoplasms (Colon Cancer) 01/01/2021 - "In a MC38 colon cancer model, intravenous injection (IV) of silicasome-encapsulated AZD1080 significantly improved biodistribution and drug delivery to the tumor site. "
3.	Endometrial Neoplasms (Endometrial Cancer) 05/10/2016 - "GSK-3β inhibitor AZD1080 may be an effective drug for treating endometrial carcinoma."
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2021 - "IV injection of encapsulated AZD1080 also resulted in significant tumor shrinkage in other syngeneic mouse tumor models, including another colorectal tumor (CT26), as well as pancreas (KPC) and lung (LLC) cancer models. "
5.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2016 - "Taken together, our results demonstrate that the GSK-3β inhibitor AZD1080 suppresses ovarian cancer development and therefore may indicate a new direction for ovarian cancer treatment." 01/01/2016 - "AZD1080 exposure suppressed ovarian cancer cell proliferation, invasion, migration, and lamellipodia formation, and induced G1 arrest, which was concentration dependent. " 01/01/2016 - "A2780 and OVCAR3 ovarian cancer cell lines were exposed to AZD1080, after which cell proliferation, cell cycle, invasion, and migration assays were performed. " 01/01/2016 - "We investigated the role of the GSK-3β inhibitor AZD1080 in ovarian cancer cell lines. " 01/01/2016 - "Role of glycogen synthase kinase-3β inhibitor AZD1080 in ovarian cancer."

Related Drugs and Biologics

1.	Glycogen Synthase (Synthase I)

Related Therapies and Procedures

1.	Intravenous Injections