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6- (2,4- dichlorophenyl)- 8- ethyl- 2- (3- fluoro- 4- (piperazin- 1- yl)phenylamino)pyrido(2,3- d)pyrimidin- 7(8H)- one

structure in first source

Also Known As:

FRAX486

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-(piperazin-1-yl)phenylamino)pyrido(2,3-d)pyrimidin-7(8H)-one: 5
  - Pyridines: 88
    - Pyridones: 14
      - 6-(2,4-dichlorophenyl)-8-ethyl-2-(3-fluoro-4-(piperazin-1-yl)phenylamino)pyrido(2,3-d)pyrimidin-7(8H)-one: 5

Experts

1.	Beck, Florian: 1 article (10/2018)
2.	Behrmann, Lena: 1 article (10/2018)
3.	Blohm, Martin: 1 article (10/2018)
4.	Bockmayr, Michael: 1 article (10/2018)
5.	Buhs, Sophia: 1 article (10/2018)
6.	Dierck, Kevin: 1 article (10/2018)
7.	Gerull, Helwe: 1 article (10/2018)
8.	Gottschling, Kristina: 1 article (10/2018)
9.	Horstmann, Martin A: 1 article (10/2018)
10.	Jeremias, Irmela: 1 article (10/2018)

Related Diseases

1.	Dermatomycoses 10/31/2023 - "In an invertebrate dermatophyte infection model, animals infected with ΔTrcla4 had higher survival rates than those infected with the wild-type, and IPA-3 and FRAX486 treatments both significantly improved animal survival rates. "
2.	Neoplasms (Cancer) 01/01/2023 - "The PAK inhibitors FRAX597 and FRAX486 in synergy with sotorasib reduced the viability of KRASG12C mutant cancer cells. "
3.	Leukemia 10/09/2018 - "Finally, combined treatment of FLT3 D835H PDX-ALL with the ATP-competitive group I PAK inhibitor FRAX486 and midostaurin in vivo significantly prolonged leukemia progression-free survival compared with midostaurin monotherapy or control. "
4.	Hypoglycemia (Reactive Hypoglycemia) 11/01/2022 - "Systemically, FRAX486 treatment normalized the levels of reactive oxidizing species in the whole blood and the fasting-induced hypoglycemia displayed by Cdkl5-Het mice. "
5.	Fragile X Syndrome (Martin Bell Syndrome) 04/02/2013 - "Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486."

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	FRAX597
3.	midostaurin
4.	sotorasib